The measurement of a fibrinogen α C-chain 5.9 kDa fragment (FIC 5.9) using MALDI-TOF MS and a stable isotope-labeled peptide standard dilution

We previously identified a 5.9 kDa peptide fragment of fibrinogen α C-chain (FIC 5.9) as a novel biomarker candidate for heavy drinking. In an effort to improve FIC 5.9 measurement for potential use in clinical diagnostics, we combined the ClinProt System and a stable isotope-labeled peptide standar...

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Veröffentlicht in:	Clinica chimica acta 2011-05, Vol.412 (11-12), p.1094-1099
Hauptverfasser:	Sogawa, Kazuyuki, Kodera, Yoshio, Noda, Kenta, Ishizuka, Yusuke, Yamada, Mako, Umemura, Hiroshi, Maruyama, Katsuya, Tomonaga, Takeshi, Yokosuka, Osamu, Nomura, Fumio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alcoholism - blood Blood Chemical Analysis - methods Fibrinogen - chemistry Humans Isotope Labeling Male Middle Aged Molecular Weight Peptide Fragments - blood Peptide Fragments - chemistry Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Young Adult
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