Side population is increased in paclitaxel-resistant ovarian cancer cell lines regardless of resistance to cisplatin

Abstract Objectives In recent years, cancer stem cells (CSCs) have been reported to be correlated with chemoresistance and may also be enriched in side populations (SPs). In this study, the relationship between resistance to paclitaxel (PTX) and cisplatin (CDDP) and side populations was examined in...

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Veröffentlicht in:	Gynecologic oncology 2011-05, Vol.121 (2), p.390-394
Hauptverfasser:	Kobayashi, Yoichi, Seino, Ken-ichiro, Hosonuma, Shinji, Ohara, Tatsuru, Itamochi, Hiroaki, Isonishi, Seiji, Kita, Tsunekazu, Wada, Haruka, Kojo, Satoshi, Kiguchi, Kazushige
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects ATP Binding Cassette Transporter, Sub-Family B ATP Binding Cassette Transporter, Sub-Family G, Member 2 ATP-Binding Cassette Transporters - biosynthesis ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Cell Line, Tumor Cisplatin - pharmacology Cystadenocarcinoma, Serous - drug therapy Cystadenocarcinoma, Serous - genetics Cystadenocarcinoma, Serous - metabolism Cystadenocarcinoma, Serous - pathology Drug Resistance, Neoplasm Female Gene Expression - drug effects Hematology, Oncology and Palliative Medicine Humans Interferon-alpha - pharmacology Interferon-α Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - pathology Obstetrics and Gynecology Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Paclitaxel - pharmacology Paclitaxel-resistance Side population
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