CD151 Amplifies Signaling by Integrin α6β1 to PI3K and Induces the Epithelial–Mesenchymal Transition in HCC Cells

Background & Aims Overexpression of CD151 is associated with poor prognosis for hepatocellular carcinoma (HCC), yet its role in pathogenesis is not known. Methods We analyzed the expression of the integrin subunit α6 by quantitative, real-time polymerase chain reaction and immunoblot analyses of...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2011-05, Vol.140 (5), p.1629-1641.e15
Hauptverfasser:	Ke, Ai–Wu, Shi, Guo–Ming, Zhou, Jian, Huang, Xiao–Yong, Shi, Ying–Hong, Ding, Zhen–Bin, Wang, Xiao–Ying, Devbhandari, Ranjan Prasad, Fan, Jia
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - biosynthesis Antigens, CD - genetics Blotting, Western Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Dedifferentiation Cell Line, Tumor Gastroenterology and Hepatology Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Integrin alpha6beta1 - biosynthesis Integrin alpha6beta1 - genetics Liver Cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Metastasis Phosphatidylinositol 3-Kinases - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Neoplasm - genetics Signal Transduction - genetics Tetraspanin 24 Tumor Invasion Tumor Progression
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