Ipilimumab: A Novel Treatment for Metastatic Melanoma

Objective: To review the mechanism of action, pharmacokinetics, efficacy, safety, drug interactions, dosing, and economic considerations of ipilimumab. Data Sources: A literature search using MEDLINE (1966-November 2010) was performed using the terms ipilimumab, metastatic melanoma, MDX-010, and MDX...

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Veröffentlicht in:	The Annals of pharmacotherapy 2011-04, Vol.45 (4), p.510-519
Hauptverfasser:	Culver, Morgan E, Gatesman, Mandy L, Mancl, Erin E, Lowe, Denise K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - therapeutic use Biological and medical sciences Clinical Trials, Phase III as Topic Dermatology Humans Ipilimumab Medical sciences Melanoma - drug therapy Melanoma - secondary Neoplasm Metastasis Pharmacology. Drug treatments Randomized Controlled Trials as Topic Skin Neoplasms - drug therapy Skin Neoplasms - secondary Tumors of the skin and soft tissue. Premalignant lesions United States
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