Pyoderma Gangrenosum‐like Lesions in Leukocyte Adhesion Deficiency I Treated with Intravenous Immunoglobulin
: A 31‐year‐old Caucasian male with leukocyte adhesion deficiency I and a 20‐year history of recurrent, painful cutaneous ulcerations on the extremities presented with fatigue and worsening pain in both legs. He had experienced minimal improvement in his leg ulcers from treatment with systemic ster...
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| Veröffentlicht in: | Pediatric dermatology 2011-03, Vol.28 (2), p.156-161 |
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| container_title | Pediatric dermatology |
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| creator | Nord, Kristin M. Pappert, Amy S. Grossman, Marc E. |
| description | : A 31‐year‐old Caucasian male with leukocyte adhesion deficiency I and a 20‐year history of recurrent, painful cutaneous ulcerations on the extremities presented with fatigue and worsening pain in both legs. He had experienced minimal improvement in his leg ulcers from treatment with systemic steroids, numerous courses of systemic antibiotics, and brief trials of infliximab and mycophenolate mofetil. He was treated with monthly intravenous immunoglobulin infusions. Upon completion of six courses of intravenous immunoglobulin his ulcerations had nearly healed for the first time in a decade. |
| doi_str_mv | 10.1111/j.1525-1470.2010.01123.x |
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He had experienced minimal improvement in his leg ulcers from treatment with systemic steroids, numerous courses of systemic antibiotics, and brief trials of infliximab and mycophenolate mofetil. He was treated with monthly intravenous immunoglobulin infusions. Upon completion of six courses of intravenous immunoglobulin his ulcerations had nearly healed for the first time in a decade.</description><identifier>ISSN: 0736-8046</identifier><identifier>EISSN: 1525-1470</identifier><identifier>DOI: 10.1111/j.1525-1470.2010.01123.x</identifier><identifier>PMID: 21366684</identifier><identifier>CODEN: PEDRDQ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biological and medical sciences ; Dermatology ; Hematologic and hematopoietic diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunoglobulins, Intravenous - administration & dosage ; Immunopathology ; Leukocyte-Adhesion Deficiency Syndrome - immunology ; Leukocyte-Adhesion Deficiency Syndrome - pathology ; Leukocyte-Adhesion Deficiency Syndrome - therapy ; Male ; Medical sciences ; Other diseases. Hematologic involvement in other diseases ; Pyoderma Gangrenosum - immunology ; Pyoderma Gangrenosum - pathology ; Pyoderma Gangrenosum - therapy ; Skin involvement in other diseases. Miscellaneous. General aspects ; Skin Ulcer - immunology ; Skin Ulcer - pathology ; Skin Ulcer - therapy</subject><ispartof>Pediatric dermatology, 2011-03, Vol.28 (2), p.156-161</ispartof><rights>2011 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3983-e26cae3fc5f7e0f25866daa07937feee66dafa8f685c1caa3e29d4c2cee457f73</citedby><cites>FETCH-LOGICAL-c3983-e26cae3fc5f7e0f25866daa07937feee66dafa8f685c1caa3e29d4c2cee457f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1525-1470.2010.01123.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1525-1470.2010.01123.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24104103$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21366684$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nord, Kristin M.</creatorcontrib><creatorcontrib>Pappert, Amy S.</creatorcontrib><creatorcontrib>Grossman, Marc E.</creatorcontrib><title>Pyoderma Gangrenosum‐like Lesions in Leukocyte Adhesion Deficiency I Treated with Intravenous Immunoglobulin</title><title>Pediatric dermatology</title><addtitle>Pediatr Dermatol</addtitle><description>: A 31‐year‐old Caucasian male with leukocyte adhesion deficiency I and a 20‐year history of recurrent, painful cutaneous ulcerations on the extremities presented with fatigue and worsening pain in both legs. He had experienced minimal improvement in his leg ulcers from treatment with systemic steroids, numerous courses of systemic antibiotics, and brief trials of infliximab and mycophenolate mofetil. He was treated with monthly intravenous immunoglobulin infusions. Upon completion of six courses of intravenous immunoglobulin his ulcerations had nearly healed for the first time in a decade.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunoglobulins, Intravenous - administration & dosage</subject><subject>Immunopathology</subject><subject>Leukocyte-Adhesion Deficiency Syndrome - immunology</subject><subject>Leukocyte-Adhesion Deficiency Syndrome - pathology</subject><subject>Leukocyte-Adhesion Deficiency Syndrome - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Other diseases. Hematologic involvement in other diseases</subject><subject>Pyoderma Gangrenosum - immunology</subject><subject>Pyoderma Gangrenosum - pathology</subject><subject>Pyoderma Gangrenosum - therapy</subject><subject>Skin involvement in other diseases. Miscellaneous. General aspects</subject><subject>Skin Ulcer - immunology</subject><subject>Skin Ulcer - pathology</subject><subject>Skin Ulcer - therapy</subject><issn>0736-8046</issn><issn>1525-1470</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtO9CAUgIn5jY6XVzBszL_qyKWl7cKF8TrJJLrQNUF6UMaWKrRqdz6Cz-iTSJ1RtxISDofvHE4-hDAlUxrXwWJKM5YlNM3JlJGYJZQyPn1dQ5Ofh39oQnIukoKkYhNthbAghBRC0A20ySgXQhTpBLmroa3ANwqfK3fnwbWhbz7e3mv7AHgOwbYuYOti2D-0eugAH1X3X2l8AsZqC04PeIavPagOKvxiu3s8c51Xz7FXH_CsaXrX3tXtbV9bt4PWjaoD7K7ObXRzdnp9fJHML89nx0fzRPOy4AkwoRVwozOTAzEsi3NXSpG85LkBgPFmVGFEkWmqleLAyirVTAOkWW5yvo3-L_s--vaph9DJxgYNda0cxKlkIXjKMlKWkSyWpPZtCB6MfPS2UX6QlMhRtlzI0akcncpRtvySLV9j6d7qk_62geqn8NtuBPZXgApa1cYrp2345VJK4uaRO1xyL7aG4c8DyKuT0zHin4zing0</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>Nord, Kristin M.</creator><creator>Pappert, Amy S.</creator><creator>Grossman, Marc E.</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201103</creationdate><title>Pyoderma Gangrenosum‐like Lesions in Leukocyte Adhesion Deficiency I Treated with Intravenous Immunoglobulin</title><author>Nord, Kristin M. ; Pappert, Amy S. ; Grossman, Marc E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3983-e26cae3fc5f7e0f25866daa07937feee66dafa8f685c1caa3e29d4c2cee457f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunoglobulins, Intravenous - administration & dosage</topic><topic>Immunopathology</topic><topic>Leukocyte-Adhesion Deficiency Syndrome - immunology</topic><topic>Leukocyte-Adhesion Deficiency Syndrome - pathology</topic><topic>Leukocyte-Adhesion Deficiency Syndrome - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Other diseases. Hematologic involvement in other diseases</topic><topic>Pyoderma Gangrenosum - immunology</topic><topic>Pyoderma Gangrenosum - pathology</topic><topic>Pyoderma Gangrenosum - therapy</topic><topic>Skin involvement in other diseases. Miscellaneous. General aspects</topic><topic>Skin Ulcer - immunology</topic><topic>Skin Ulcer - pathology</topic><topic>Skin Ulcer - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nord, Kristin M.</creatorcontrib><creatorcontrib>Pappert, Amy S.</creatorcontrib><creatorcontrib>Grossman, Marc E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nord, Kristin M.</au><au>Pappert, Amy S.</au><au>Grossman, Marc E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pyoderma Gangrenosum‐like Lesions in Leukocyte Adhesion Deficiency I Treated with Intravenous Immunoglobulin</atitle><jtitle>Pediatric dermatology</jtitle><addtitle>Pediatr Dermatol</addtitle><date>2011-03</date><risdate>2011</risdate><volume>28</volume><issue>2</issue><spage>156</spage><epage>161</epage><pages>156-161</pages><issn>0736-8046</issn><eissn>1525-1470</eissn><coden>PEDRDQ</coden><abstract>: A 31‐year‐old Caucasian male with leukocyte adhesion deficiency I and a 20‐year history of recurrent, painful cutaneous ulcerations on the extremities presented with fatigue and worsening pain in both legs. He had experienced minimal improvement in his leg ulcers from treatment with systemic steroids, numerous courses of systemic antibiotics, and brief trials of infliximab and mycophenolate mofetil. He was treated with monthly intravenous immunoglobulin infusions. Upon completion of six courses of intravenous immunoglobulin his ulcerations had nearly healed for the first time in a decade.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21366684</pmid><doi>10.1111/j.1525-1470.2010.01123.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Pediatric dermatology, 2011-03, Vol.28 (2), p.156-161 |
| issn | 0736-8046 1525-1470 |
| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Adult Biological and medical sciences Dermatology Hematologic and hematopoietic diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunoglobulins, Intravenous - administration & dosage Immunopathology Leukocyte-Adhesion Deficiency Syndrome - immunology Leukocyte-Adhesion Deficiency Syndrome - pathology Leukocyte-Adhesion Deficiency Syndrome - therapy Male Medical sciences Other diseases. Hematologic involvement in other diseases Pyoderma Gangrenosum - immunology Pyoderma Gangrenosum - pathology Pyoderma Gangrenosum - therapy Skin involvement in other diseases. Miscellaneous. General aspects Skin Ulcer - immunology Skin Ulcer - pathology Skin Ulcer - therapy |
| title | Pyoderma Gangrenosum‐like Lesions in Leukocyte Adhesion Deficiency I Treated with Intravenous Immunoglobulin |
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