Adenoviral therapy is more effective in gemcitabine-resistant pancreatic cancer than in gemcitabine-sensitive cells

Although gemcitabine is the standard treatment for pancreatic cancer, this particular type of cancer develops rapidly and has intrinsic chemoresistance. Chemoresistance plays a critical role in tumor progression, invasion and migration. Nevertheless, the effect of adenoviral therapy on chemoresistan...

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Veröffentlicht in:	Anticancer research 2011-04, Vol.31 (4), p.1279-1287
Hauptverfasser:	Yasui, Takaharu, Ohuchida, Kenoki, Zhao, Ming, Cui, Lin, Onimaru, Manabu, Egami, Takuya, Fujita, Hayato, Ohtsuka, Takao, Mizumoto, Kazuhiro, Matsumoto, Kunio, Tanaka, Masao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Antimetabolites, Antineoplastic - therapeutic use Biomarkers, Tumor - genetics Blotting, Western Cell Adhesion Cell Line, Tumor Cell Movement Cell Proliferation Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Drug Resistance, Neoplasm - genetics Genetic Therapy Green Fluorescent Proteins - genetics Hepatocyte Growth Factor - genetics Humans Pancreatic Neoplasms - genetics Pancreatic Neoplasms - therapy Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Transgenes - physiology
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