Laparoscopic Donor Nephrectomy Does Not Compromise Outcomes for Pediatric Transplant Recipients
Despite the apparent safety of laparoscopic kidney procurement (laparoscopic donor nephrectomy [LDN]) in adults, doubts have persisted about its use in pediatric recipients, following the publication of a United Network for Organ Sharing analysis, which suggested that rejection rates were higher aft...
Gespeichert in:
| Veröffentlicht in: | Transplantation 2011-05, Vol.91 (9), p.1005-1009 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1009 |
|---|---|
| container_issue | 9 |
| container_start_page | 1005 |
| container_title | Transplantation |
| container_volume | 91 |
| creator | MAMODE, Nizam JOHNSON, Rachel J HADJIANASTASSIOU, Vassilis G |
| description | Despite the apparent safety of laparoscopic kidney procurement (laparoscopic donor nephrectomy [LDN]) in adults, doubts have persisted about its use in pediatric recipients, following the publication of a United Network for Organ Sharing analysis, which suggested that rejection rates were higher after LDN when compared with open procurement (open donor nephrectomy [ODN]) for children. The aim of this study was to determine whether acute rejection rates, and graft and patient survival, were worse after LDN for pediatric recipients. The analysis included both short and medium term outcomes.
The UK Transplant Registry, a validated database with mandatory reporting, was interrogated from 2000 to 2007 for outcomes of pediatric recipients. A total of 306 recipients were identified, 119 of which had LDN.
Acute rejection was higher in the ODN group, compared with LDN (40.6% vs. 24.3% P=0.007). Graft survival at 1 year (99.2% vs. 94.3% P=0.03) and 3 years (99.2% vs 91.4%, P=0.01) was worse after ODN. There were more deaths after ODN (4 vs. 0), but this did not reach statistical significance. Cox proportional hazards modeling showed that the negative effect of ODN on graft survival was reduced when adjusted for acute rejection.
LDN seems to be safe for pediatric recipients in both the short and longer terms. |
| doi_str_mv | 10.1097/TP.0b013e318211d32a |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_863423656</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>863423656</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-1e763be0d952f80bdbc593c16eb120954adf81ff1b75645e8bed979058efd403</originalsourceid><addsrcrecordid>eNp9kU9r3DAQxUVJaTZpP0Gh-BKai9MZj_XHx7JpksKSLMV3I8sj6rBeuZL3kG9flWxa6CGngeH3Zh7vCfER4Qqh0V_a7RX0gMSEpkIcqLJvxAol1aUCAydiBVBjiUT6VJyl9AgAkrR-J04rpEoh6ZXoNna2MSQX5tEV12EfYnHP88_IbgnTU95wKu7DUqzDNMcwjYmLh8PiwpT3PsNbHka7xCxuo92neWf3S_GD3TiPvF_Se_HW213iD8d5Ltqbb-36rtw83H5ff92UrsZqKZG1op5haGTlDfRD72RDDhX3WEEjazt4g95jr6WqJZueh0Y3IA37oQY6F5-fz2aPvw6cli47dbzLbjgcUmcU1RUpqTJ5-SqJAMZQoxqdUXpGXQ4oRfbdHMfJxqcMdX8q6Npt938FWfXp-ODQTzz81bxknoGLI2CTszufY3Nj-sfVKA2Rod9RlZBe</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1008839697</pqid></control><display><type>article</type><title>Laparoscopic Donor Nephrectomy Does Not Compromise Outcomes for Pediatric Transplant Recipients</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>MAMODE, Nizam ; JOHNSON, Rachel J ; HADJIANASTASSIOU, Vassilis G</creator><creatorcontrib>MAMODE, Nizam ; JOHNSON, Rachel J ; HADJIANASTASSIOU, Vassilis G</creatorcontrib><description>Despite the apparent safety of laparoscopic kidney procurement (laparoscopic donor nephrectomy [LDN]) in adults, doubts have persisted about its use in pediatric recipients, following the publication of a United Network for Organ Sharing analysis, which suggested that rejection rates were higher after LDN when compared with open procurement (open donor nephrectomy [ODN]) for children. The aim of this study was to determine whether acute rejection rates, and graft and patient survival, were worse after LDN for pediatric recipients. The analysis included both short and medium term outcomes.
The UK Transplant Registry, a validated database with mandatory reporting, was interrogated from 2000 to 2007 for outcomes of pediatric recipients. A total of 306 recipients were identified, 119 of which had LDN.
Acute rejection was higher in the ODN group, compared with LDN (40.6% vs. 24.3% P=0.007). Graft survival at 1 year (99.2% vs. 94.3% P=0.03) and 3 years (99.2% vs 91.4%, P=0.01) was worse after ODN. There were more deaths after ODN (4 vs. 0), but this did not reach statistical significance. Cox proportional hazards modeling showed that the negative effect of ODN on graft survival was reduced when adjusted for acute rejection.
LDN seems to be safe for pediatric recipients in both the short and longer terms.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/TP.0b013e318211d32a</identifier><identifier>PMID: 21326137</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Child ; Child, Preschool ; Children ; Digestive system. Abdomen ; Donors ; Endoscopy ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Graft rejection ; Graft Survival ; Humans ; Infant ; Investigative techniques, diagnostic techniques (general aspects) ; Kaplan-Meier Estimate ; Kidney ; Kidney Transplantation - adverse effects ; Laparoscopy ; Laparoscopy - adverse effects ; Laparoscopy - methods ; Living Donors ; Male ; Medical sciences ; Nephrectomy ; Nephrectomy - adverse effects ; Nephrectomy - methods ; Oligonucleotides ; Pediatrics ; Proportional Hazards Models ; Registries ; Statistics ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; Survival ; Tissue and Organ Harvesting - adverse effects ; Tissue and Organ Harvesting - methods ; Tissue, organ and graft immunology ; Treatment Outcome ; United Kingdom</subject><ispartof>Transplantation, 2011-05, Vol.91 (9), p.1005-1009</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-1e763be0d952f80bdbc593c16eb120954adf81ff1b75645e8bed979058efd403</citedby><cites>FETCH-LOGICAL-c412t-1e763be0d952f80bdbc593c16eb120954adf81ff1b75645e8bed979058efd403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24158338$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21326137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MAMODE, Nizam</creatorcontrib><creatorcontrib>JOHNSON, Rachel J</creatorcontrib><creatorcontrib>HADJIANASTASSIOU, Vassilis G</creatorcontrib><title>Laparoscopic Donor Nephrectomy Does Not Compromise Outcomes for Pediatric Transplant Recipients</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Despite the apparent safety of laparoscopic kidney procurement (laparoscopic donor nephrectomy [LDN]) in adults, doubts have persisted about its use in pediatric recipients, following the publication of a United Network for Organ Sharing analysis, which suggested that rejection rates were higher after LDN when compared with open procurement (open donor nephrectomy [ODN]) for children. The aim of this study was to determine whether acute rejection rates, and graft and patient survival, were worse after LDN for pediatric recipients. The analysis included both short and medium term outcomes.
The UK Transplant Registry, a validated database with mandatory reporting, was interrogated from 2000 to 2007 for outcomes of pediatric recipients. A total of 306 recipients were identified, 119 of which had LDN.
Acute rejection was higher in the ODN group, compared with LDN (40.6% vs. 24.3% P=0.007). Graft survival at 1 year (99.2% vs. 94.3% P=0.03) and 3 years (99.2% vs 91.4%, P=0.01) was worse after ODN. There were more deaths after ODN (4 vs. 0), but this did not reach statistical significance. Cox proportional hazards modeling showed that the negative effect of ODN on graft survival was reduced when adjusted for acute rejection.
LDN seems to be safe for pediatric recipients in both the short and longer terms.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Digestive system. Abdomen</subject><subject>Donors</subject><subject>Endoscopy</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Graft rejection</subject><subject>Graft Survival</subject><subject>Humans</subject><subject>Infant</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Kaplan-Meier Estimate</subject><subject>Kidney</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Laparoscopy</subject><subject>Laparoscopy - adverse effects</subject><subject>Laparoscopy - methods</subject><subject>Living Donors</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrectomy</subject><subject>Nephrectomy - adverse effects</subject><subject>Nephrectomy - methods</subject><subject>Oligonucleotides</subject><subject>Pediatrics</subject><subject>Proportional Hazards Models</subject><subject>Registries</subject><subject>Statistics</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><subject>Survival</subject><subject>Tissue and Organ Harvesting - adverse effects</subject><subject>Tissue and Organ Harvesting - methods</subject><subject>Tissue, organ and graft immunology</subject><subject>Treatment Outcome</subject><subject>United Kingdom</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9r3DAQxUVJaTZpP0Gh-BKai9MZj_XHx7JpksKSLMV3I8sj6rBeuZL3kG9flWxa6CGngeH3Zh7vCfER4Qqh0V_a7RX0gMSEpkIcqLJvxAol1aUCAydiBVBjiUT6VJyl9AgAkrR-J04rpEoh6ZXoNna2MSQX5tEV12EfYnHP88_IbgnTU95wKu7DUqzDNMcwjYmLh8PiwpT3PsNbHka7xCxuo92neWf3S_GD3TiPvF_Se_HW213iD8d5Ltqbb-36rtw83H5ff92UrsZqKZG1op5haGTlDfRD72RDDhX3WEEjazt4g95jr6WqJZueh0Y3IA37oQY6F5-fz2aPvw6cli47dbzLbjgcUmcU1RUpqTJ5-SqJAMZQoxqdUXpGXQ4oRfbdHMfJxqcMdX8q6Npt938FWfXp-ODQTzz81bxknoGLI2CTszufY3Nj-sfVKA2Rod9RlZBe</recordid><startdate>20110515</startdate><enddate>20110515</enddate><creator>MAMODE, Nizam</creator><creator>JOHNSON, Rachel J</creator><creator>HADJIANASTASSIOU, Vassilis G</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20110515</creationdate><title>Laparoscopic Donor Nephrectomy Does Not Compromise Outcomes for Pediatric Transplant Recipients</title><author>MAMODE, Nizam ; JOHNSON, Rachel J ; HADJIANASTASSIOU, Vassilis G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-1e763be0d952f80bdbc593c16eb120954adf81ff1b75645e8bed979058efd403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Digestive system. Abdomen</topic><topic>Donors</topic><topic>Endoscopy</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Graft rejection</topic><topic>Graft Survival</topic><topic>Humans</topic><topic>Infant</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Kaplan-Meier Estimate</topic><topic>Kidney</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Laparoscopy</topic><topic>Laparoscopy - adverse effects</topic><topic>Laparoscopy - methods</topic><topic>Living Donors</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrectomy</topic><topic>Nephrectomy - adverse effects</topic><topic>Nephrectomy - methods</topic><topic>Oligonucleotides</topic><topic>Pediatrics</topic><topic>Proportional Hazards Models</topic><topic>Registries</topic><topic>Statistics</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><topic>Survival</topic><topic>Tissue and Organ Harvesting - adverse effects</topic><topic>Tissue and Organ Harvesting - methods</topic><topic>Tissue, organ and graft immunology</topic><topic>Treatment Outcome</topic><topic>United Kingdom</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MAMODE, Nizam</creatorcontrib><creatorcontrib>JOHNSON, Rachel J</creatorcontrib><creatorcontrib>HADJIANASTASSIOU, Vassilis G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MAMODE, Nizam</au><au>JOHNSON, Rachel J</au><au>HADJIANASTASSIOU, Vassilis G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Laparoscopic Donor Nephrectomy Does Not Compromise Outcomes for Pediatric Transplant Recipients</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2011-05-15</date><risdate>2011</risdate><volume>91</volume><issue>9</issue><spage>1005</spage><epage>1009</epage><pages>1005-1009</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Despite the apparent safety of laparoscopic kidney procurement (laparoscopic donor nephrectomy [LDN]) in adults, doubts have persisted about its use in pediatric recipients, following the publication of a United Network for Organ Sharing analysis, which suggested that rejection rates were higher after LDN when compared with open procurement (open donor nephrectomy [ODN]) for children. The aim of this study was to determine whether acute rejection rates, and graft and patient survival, were worse after LDN for pediatric recipients. The analysis included both short and medium term outcomes.
The UK Transplant Registry, a validated database with mandatory reporting, was interrogated from 2000 to 2007 for outcomes of pediatric recipients. A total of 306 recipients were identified, 119 of which had LDN.
Acute rejection was higher in the ODN group, compared with LDN (40.6% vs. 24.3% P=0.007). Graft survival at 1 year (99.2% vs. 94.3% P=0.03) and 3 years (99.2% vs 91.4%, P=0.01) was worse after ODN. There were more deaths after ODN (4 vs. 0), but this did not reach statistical significance. Cox proportional hazards modeling showed that the negative effect of ODN on graft survival was reduced when adjusted for acute rejection.
LDN seems to be safe for pediatric recipients in both the short and longer terms.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>21326137</pmid><doi>10.1097/TP.0b013e318211d32a</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1337 |
| ispartof | Transplantation, 2011-05, Vol.91 (9), p.1005-1009 |
| issn | 0041-1337 1534-6080 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_863423656 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Biological and medical sciences Child Child, Preschool Children Digestive system. Abdomen Donors Endoscopy Female Fundamental and applied biological sciences. Psychology Fundamental immunology Graft rejection Graft Survival Humans Infant Investigative techniques, diagnostic techniques (general aspects) Kaplan-Meier Estimate Kidney Kidney Transplantation - adverse effects Laparoscopy Laparoscopy - adverse effects Laparoscopy - methods Living Donors Male Medical sciences Nephrectomy Nephrectomy - adverse effects Nephrectomy - methods Oligonucleotides Pediatrics Proportional Hazards Models Registries Statistics Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Survival Tissue and Organ Harvesting - adverse effects Tissue and Organ Harvesting - methods Tissue, organ and graft immunology Treatment Outcome United Kingdom |
| title | Laparoscopic Donor Nephrectomy Does Not Compromise Outcomes for Pediatric Transplant Recipients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T11%3A12%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Laparoscopic%20Donor%20Nephrectomy%20Does%20Not%20Compromise%20Outcomes%20for%20Pediatric%20Transplant%20Recipients&rft.jtitle=Transplantation&rft.au=MAMODE,%20Nizam&rft.date=2011-05-15&rft.volume=91&rft.issue=9&rft.spage=1005&rft.epage=1009&rft.pages=1005-1009&rft.issn=0041-1337&rft.eissn=1534-6080&rft.coden=TRPLAU&rft_id=info:doi/10.1097/TP.0b013e318211d32a&rft_dat=%3Cproquest_cross%3E863423656%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1008839697&rft_id=info:pmid/21326137&rfr_iscdi=true |