Follicular variant of peripheral T‐cell lymphoma mimicking follicular lymphoma: A case report with a review of the Literature
Peripheral T‐cell lymphoma (PTCL) with a follicular growth pattern is very rare. Herein, a case of follicular variant of PTCL in a 50‐year‐old man who complained of tonsillar and generalized lymph node swelling is reported. The resected tonsil revealed a vague nodular growth pattern of atypical cell...
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| Veröffentlicht in: | Pathology international 2011-05, Vol.61 (5), p.326-330 |
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| creator | Goto, Naoe Tsurumi, Hisashi Sawada, Michio Kanemura, Nobuhiro Hara, Takeshi Kasahara, Senji Kito, Yusuke Takada, Katsuyoshi Sato, Yasuharu Yoshino, Tadashi Moriwaki, Hisataka Takami, Tsuyoshi |
| description | Peripheral T‐cell lymphoma (PTCL) with a follicular growth pattern is very rare. Herein, a case of follicular variant of PTCL in a 50‐year‐old man who complained of tonsillar and generalized lymph node swelling is reported. The resected tonsil revealed a vague nodular growth pattern of atypical cells, medium to large in size, with abundant pale cytoplasm. The lymphoma cells were CD3+ CD4+ CD5+ CD8‐ CD10+ CD56‐ CD57‐ BCL6+ PD‐1+ CXCL13+ and were associated with a meshwork of CD21+ follicular dendritic cells. Molecular studies revealed clonal rearrangement of the T‐cell receptor gamma chain gene but not of the immunoglobulin gene. Cytogenetic analysis disclosed a complex abnormality in 18 of 20 cells with the exclusion of t(5; 9). These findings suggest that the present case is a follicular variant of PTCL derived from follicular T‐helper cells. |
| doi_str_mv | 10.1111/j.1440-1827.2011.02656.x |
| format | Article |
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Herein, a case of follicular variant of PTCL in a 50‐year‐old man who complained of tonsillar and generalized lymph node swelling is reported. The resected tonsil revealed a vague nodular growth pattern of atypical cells, medium to large in size, with abundant pale cytoplasm. The lymphoma cells were CD3+ CD4+ CD5+ CD8‐ CD10+ CD56‐ CD57‐ BCL6+ PD‐1+ CXCL13+ and were associated with a meshwork of CD21+ follicular dendritic cells. Molecular studies revealed clonal rearrangement of the T‐cell receptor gamma chain gene but not of the immunoglobulin gene. Cytogenetic analysis disclosed a complex abnormality in 18 of 20 cells with the exclusion of t(5; 9). These findings suggest that the present case is a follicular variant of PTCL derived from follicular T‐helper cells.</description><identifier>ISSN: 1320-5463</identifier><identifier>EISSN: 1440-1827</identifier><identifier>DOI: 10.1111/j.1440-1827.2011.02656.x</identifier><identifier>PMID: 21501301</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Antigens, CD - metabolism ; Dendritic Cells, Follicular - immunology ; Diagnosis, Differential ; follicular T‐helper cells ; follicular variant PTCL ; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor - genetics ; Humans ; Immunohistochemistry ; Lymph Nodes - pathology ; Lymphoma, Follicular - genetics ; Lymphoma, Follicular - immunology ; Lymphoma, Follicular - metabolism ; Lymphoma, Follicular - pathology ; Lymphoma, T-Cell, Peripheral - genetics ; Lymphoma, T-Cell, Peripheral - metabolism ; Lymphoma, T-Cell, Peripheral - pathology ; Male ; Middle Aged ; phenotype ; Positron-Emission Tomography - methods ; T-Lymphocyte Subsets - metabolism ; T-Lymphocytes, Helper-Inducer - metabolism ; Tomography, X-Ray Computed</subject><ispartof>Pathology international, 2011-05, Vol.61 (5), p.326-330</ispartof><rights>2011 The Authors. Pathology International © 2011 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd</rights><rights>2011 The Authors. 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| identifier | ISSN: 1320-5463 |
| ispartof | Pathology international, 2011-05, Vol.61 (5), p.326-330 |
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| language | eng |
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| subjects | Antigens, CD - metabolism Dendritic Cells, Follicular - immunology Diagnosis, Differential follicular T‐helper cells follicular variant PTCL Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor - genetics Humans Immunohistochemistry Lymph Nodes - pathology Lymphoma, Follicular - genetics Lymphoma, Follicular - immunology Lymphoma, Follicular - metabolism Lymphoma, Follicular - pathology Lymphoma, T-Cell, Peripheral - genetics Lymphoma, T-Cell, Peripheral - metabolism Lymphoma, T-Cell, Peripheral - pathology Male Middle Aged phenotype Positron-Emission Tomography - methods T-Lymphocyte Subsets - metabolism T-Lymphocytes, Helper-Inducer - metabolism Tomography, X-Ray Computed |
| title | Follicular variant of peripheral T‐cell lymphoma mimicking follicular lymphoma: A case report with a review of the Literature |
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