Preparation and evaluation of a new nano pharmaceutical excipients and drug delivery system based in polyvinylpyrrolidone and silicate

This work describes the preparation of new nanocomposites based on lamellar silicates (AAM-alkyl ammonium montmorillonite) obtained by the intercalation of PVP K30 and glyceril monostearate. By XRD, TGA and DSC analysis the AAM was characterized and its compactation characteristics, functionality an...

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Veröffentlicht in:	Journal of pharmacy & pharmaceutical sciences 2011, Vol.14 (1), p.17-35
Hauptverfasser:	Dornelas, Camila Braga, da Silva, Alex Moura, Dantas, Cide Brizio, Rodrigues, Carlos Rangel, Coutinho, Sandra Solange, Sathler, Plínio Cunha, Castro, Helena Carla, Dias, Luiza Rosaria Sousa, de Sousa, Valéria Pereira, Cabral, Lúcio Mendes
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bentonite - chemistry Bentonite - toxicity Calorimetry, Differential Scanning Drug Delivery Systems Excipients - chemistry Excipients - toxicity Methyldopa - administration & dosage Methyldopa - chemistry Mice Nanocomposites Povidone - chemistry Silicates - chemistry Solubility Tablets Theophylline - administration & dosage Theophylline - chemistry Thermogravimetry Toxicity Tests X-Ray Diffraction
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