Oxygen Therapy for Acute Ocular Chemical or Thermal Burns: A Pilot Study
Purpose To evaluate the effect of systemic oxygen therapy in the management of acute ocular chemical and thermal burns. Design Prospective, nonrandomized, comparative, interventional case series. Methods Twenty-four eyes of 22 patients with grade III to IV acute ocular chemical and thermal burns rec...
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description | Purpose To evaluate the effect of systemic oxygen therapy in the management of acute ocular chemical and thermal burns. Design Prospective, nonrandomized, comparative, interventional case series. Methods Twenty-four eyes of 22 patients with grade III to IV acute ocular chemical and thermal burns received conventional medical therapy. The oxygen therapy group (13 eyes) additionally received 100% oxygen using a simple mask at a flow rate of 10 L/minute for 1 hour twice daily. Main outcome measures were time for healing of the corneal epithelial defect and improvement in perilimbal ischemia. Secondary outcome measures included visual acuity, corneal transparency and vascularization, and complications. Results Corneal epithelial defects healed within 15.23 ± 3.94 days (range, 10 to 21 days) in the oxygen group versus 59.9 ± 23.33 days (range, 28 to 95 days) in controls ( P < .001). Vascularization of ischemic areas was complete in 14.54 ± 2.70 days (range, 10 to 21 days) in the oxygen group versus 45.09 ± 22.20 days (range, 25 to 105 days) in controls ( P = .001). In the oxygen group, the cornea was more transparent and less vascularized 3 and 6 months after injury. Mean final visual acuity (logarithm of the minimal angle of resolution) was 0.40 ± 0.52 (range, 0 to 1.3) versus 1.11 ± 0.83 (range, 0.1 to 3) in the oxygen and control groups, respectively ( P = .018). In the oxygen group, symblepharon or corneoscleral melting did not develop in any patient; however, in the control group, symblepharon developed in 3 eyes and corneoscleral melting developed in 1 patient. Conclusions In the acute phase of ocular chemical or thermal burns, oxygen therapy improves limbal ischemia, accelerates epithelialization, increases corneal transparency, and decreases corneal vascularization. It also may improve visual acuity and reduce complications. |
doi_str_mv | 10.1016/j.ajo.2010.11.005 |
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Design Prospective, nonrandomized, comparative, interventional case series. Methods Twenty-four eyes of 22 patients with grade III to IV acute ocular chemical and thermal burns received conventional medical therapy. The oxygen therapy group (13 eyes) additionally received 100% oxygen using a simple mask at a flow rate of 10 L/minute for 1 hour twice daily. Main outcome measures were time for healing of the corneal epithelial defect and improvement in perilimbal ischemia. Secondary outcome measures included visual acuity, corneal transparency and vascularization, and complications. Results Corneal epithelial defects healed within 15.23 ± 3.94 days (range, 10 to 21 days) in the oxygen group versus 59.9 ± 23.33 days (range, 28 to 95 days) in controls ( P < .001). Vascularization of ischemic areas was complete in 14.54 ± 2.70 days (range, 10 to 21 days) in the oxygen group versus 45.09 ± 22.20 days (range, 25 to 105 days) in controls ( P = .001). In the oxygen group, the cornea was more transparent and less vascularized 3 and 6 months after injury. Mean final visual acuity (logarithm of the minimal angle of resolution) was 0.40 ± 0.52 (range, 0 to 1.3) versus 1.11 ± 0.83 (range, 0.1 to 3) in the oxygen and control groups, respectively ( P = .018). In the oxygen group, symblepharon or corneoscleral melting did not develop in any patient; however, in the control group, symblepharon developed in 3 eyes and corneoscleral melting developed in 1 patient. Conclusions In the acute phase of ocular chemical or thermal burns, oxygen therapy improves limbal ischemia, accelerates epithelialization, increases corneal transparency, and decreases corneal vascularization. It also may improve visual acuity and reduce complications.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/j.ajo.2010.11.005</identifier><identifier>PMID: 21310381</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acute Disease ; Adolescent ; Adult ; Biological and medical sciences ; Burns ; Burns, Chemical - therapy ; Child ; Colleges & universities ; Corneal Diseases - therapy ; Cytokines ; Disease ; Ear diseases ; Epithelium, Corneal - physiology ; Eye Burns - chemically induced ; Follow-Up Studies ; Health care ; Hospitals ; Humans ; Irrigation ; Ischemia ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Ophthalmology ; Oxygen ; Oxygen - administration & dosage ; Oxygen Inhalation Therapy ; Oxygen therapy ; Pilot Projects ; Prospective Studies ; Respiratory therapy ; Stem cells ; Traumas. Diseases due to physical agents ; Treatment Outcome ; Visual Acuity ; Vitamin C ; Wound Healing - physiology ; Young Adult</subject><ispartof>American journal of ophthalmology, 2011-05, Vol.151 (5), p.823-828</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-5f2367d9ce7231c1d9f9575106d9393aa883f2fa8bcc1b6f1ba716eda16014943</citedby><cites>FETCH-LOGICAL-c465t-5f2367d9ce7231c1d9f9575106d9393aa883f2fa8bcc1b6f1ba716eda16014943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajo.2010.11.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24132834$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21310381$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharifipour, Farideh</creatorcontrib><creatorcontrib>Baradaran-Rafii, Alireza</creatorcontrib><creatorcontrib>Idani, Esmaeil</creatorcontrib><creatorcontrib>Zamani, Mitra</creatorcontrib><creatorcontrib>Jabbarpoor Bonyadi, Mohammad Hossein</creatorcontrib><title>Oxygen Therapy for Acute Ocular Chemical or Thermal Burns: A Pilot Study</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>Purpose To evaluate the effect of systemic oxygen therapy in the management of acute ocular chemical and thermal burns. Design Prospective, nonrandomized, comparative, interventional case series. Methods Twenty-four eyes of 22 patients with grade III to IV acute ocular chemical and thermal burns received conventional medical therapy. The oxygen therapy group (13 eyes) additionally received 100% oxygen using a simple mask at a flow rate of 10 L/minute for 1 hour twice daily. Main outcome measures were time for healing of the corneal epithelial defect and improvement in perilimbal ischemia. Secondary outcome measures included visual acuity, corneal transparency and vascularization, and complications. Results Corneal epithelial defects healed within 15.23 ± 3.94 days (range, 10 to 21 days) in the oxygen group versus 59.9 ± 23.33 days (range, 28 to 95 days) in controls ( P < .001). Vascularization of ischemic areas was complete in 14.54 ± 2.70 days (range, 10 to 21 days) in the oxygen group versus 45.09 ± 22.20 days (range, 25 to 105 days) in controls ( P = .001). In the oxygen group, the cornea was more transparent and less vascularized 3 and 6 months after injury. Mean final visual acuity (logarithm of the minimal angle of resolution) was 0.40 ± 0.52 (range, 0 to 1.3) versus 1.11 ± 0.83 (range, 0.1 to 3) in the oxygen and control groups, respectively ( P = .018). In the oxygen group, symblepharon or corneoscleral melting did not develop in any patient; however, in the control group, symblepharon developed in 3 eyes and corneoscleral melting developed in 1 patient. Conclusions In the acute phase of ocular chemical or thermal burns, oxygen therapy improves limbal ischemia, accelerates epithelialization, increases corneal transparency, and decreases corneal vascularization. It also may improve visual acuity and reduce complications.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Burns</subject><subject>Burns, Chemical - therapy</subject><subject>Child</subject><subject>Colleges & universities</subject><subject>Corneal Diseases - therapy</subject><subject>Cytokines</subject><subject>Disease</subject><subject>Ear diseases</subject><subject>Epithelium, Corneal - physiology</subject><subject>Eye Burns - chemically induced</subject><subject>Follow-Up Studies</subject><subject>Health care</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Irrigation</subject><subject>Ischemia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Ophthalmology</subject><subject>Oxygen</subject><subject>Oxygen - administration & dosage</subject><subject>Oxygen Inhalation Therapy</subject><subject>Oxygen therapy</subject><subject>Pilot Projects</subject><subject>Prospective Studies</subject><subject>Respiratory therapy</subject><subject>Stem cells</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Treatment Outcome</subject><subject>Visual Acuity</subject><subject>Vitamin C</subject><subject>Wound Healing - physiology</subject><subject>Young Adult</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kt-L1DAQx4Mo3nr6B_giAZF76ppJ2jRREPYW9YSDFe58Dtl06qX2x5q0Yv97U3b14B58ygzzmeE73wwhL4GtgYF826xtM6w5W3JYM1Y8IitQpc5AaXhMVowxnmmh8zPyLMYmpbLMy6fkjIMAJhSsyNXu9_wde3p7h8EeZloPgW7cNCLduam1gW7vsPPOtjQVFqhL4eUU-viObuhX3w4jvRmnan5OntS2jfji9J6Tb58-3m6vsuvd5y_bzXXmclmMWVFzIctKOyy5AAeVrnVRFsBklYQKa5USNa-t2jsHe1nD3pYgsbIgGeQ6F-fk4jj3EIafE8bRdD46bFvb4zBFoyQvNStUmcjXD8hmSMKTOJOWl4XihSoSBUfKhSHGgLU5BN_ZMCfILC6bxiSXzeKyATDJ5dTz6jR52ndY_ev4a2sC3pwAG5N3dbC98_Gey0FwJZZl3h85TI798hhMdB57h5UP6EZTDf6_Mj486Hat75fP-oEzxvttTeSGmZvlHJZrgBSkK-HiDwzJq6o</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Sharifipour, Farideh</creator><creator>Baradaran-Rafii, Alireza</creator><creator>Idani, Esmaeil</creator><creator>Zamani, Mitra</creator><creator>Jabbarpoor Bonyadi, Mohammad Hossein</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20110501</creationdate><title>Oxygen Therapy for Acute Ocular Chemical or Thermal Burns: A Pilot Study</title><author>Sharifipour, Farideh ; Baradaran-Rafii, Alireza ; Idani, Esmaeil ; Zamani, Mitra ; Jabbarpoor Bonyadi, Mohammad Hossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-5f2367d9ce7231c1d9f9575106d9393aa883f2fa8bcc1b6f1ba716eda16014943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Burns</topic><topic>Burns, Chemical - therapy</topic><topic>Child</topic><topic>Colleges & universities</topic><topic>Corneal Diseases - therapy</topic><topic>Cytokines</topic><topic>Disease</topic><topic>Ear diseases</topic><topic>Epithelium, Corneal - physiology</topic><topic>Eye Burns - chemically induced</topic><topic>Follow-Up Studies</topic><topic>Health care</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Irrigation</topic><topic>Ischemia</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Ophthalmology</topic><topic>Oxygen</topic><topic>Oxygen - administration & dosage</topic><topic>Oxygen Inhalation Therapy</topic><topic>Oxygen therapy</topic><topic>Pilot Projects</topic><topic>Prospective Studies</topic><topic>Respiratory therapy</topic><topic>Stem cells</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Treatment Outcome</topic><topic>Visual Acuity</topic><topic>Vitamin C</topic><topic>Wound Healing - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharifipour, Farideh</creatorcontrib><creatorcontrib>Baradaran-Rafii, Alireza</creatorcontrib><creatorcontrib>Idani, Esmaeil</creatorcontrib><creatorcontrib>Zamani, Mitra</creatorcontrib><creatorcontrib>Jabbarpoor Bonyadi, Mohammad Hossein</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharifipour, Farideh</au><au>Baradaran-Rafii, Alireza</au><au>Idani, Esmaeil</au><au>Zamani, Mitra</au><au>Jabbarpoor Bonyadi, Mohammad Hossein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxygen Therapy for Acute Ocular Chemical or Thermal Burns: A Pilot Study</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>151</volume><issue>5</issue><spage>823</spage><epage>828</epage><pages>823-828</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>Purpose To evaluate the effect of systemic oxygen therapy in the management of acute ocular chemical and thermal burns. Design Prospective, nonrandomized, comparative, interventional case series. Methods Twenty-four eyes of 22 patients with grade III to IV acute ocular chemical and thermal burns received conventional medical therapy. The oxygen therapy group (13 eyes) additionally received 100% oxygen using a simple mask at a flow rate of 10 L/minute for 1 hour twice daily. Main outcome measures were time for healing of the corneal epithelial defect and improvement in perilimbal ischemia. Secondary outcome measures included visual acuity, corneal transparency and vascularization, and complications. Results Corneal epithelial defects healed within 15.23 ± 3.94 days (range, 10 to 21 days) in the oxygen group versus 59.9 ± 23.33 days (range, 28 to 95 days) in controls ( P < .001). Vascularization of ischemic areas was complete in 14.54 ± 2.70 days (range, 10 to 21 days) in the oxygen group versus 45.09 ± 22.20 days (range, 25 to 105 days) in controls ( P = .001). In the oxygen group, the cornea was more transparent and less vascularized 3 and 6 months after injury. Mean final visual acuity (logarithm of the minimal angle of resolution) was 0.40 ± 0.52 (range, 0 to 1.3) versus 1.11 ± 0.83 (range, 0.1 to 3) in the oxygen and control groups, respectively ( P = .018). In the oxygen group, symblepharon or corneoscleral melting did not develop in any patient; however, in the control group, symblepharon developed in 3 eyes and corneoscleral melting developed in 1 patient. Conclusions In the acute phase of ocular chemical or thermal burns, oxygen therapy improves limbal ischemia, accelerates epithelialization, increases corneal transparency, and decreases corneal vascularization. It also may improve visual acuity and reduce complications.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21310381</pmid><doi>10.1016/j.ajo.2010.11.005</doi><tpages>6</tpages></addata></record> |
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subjects | Acute Disease Adolescent Adult Biological and medical sciences Burns Burns, Chemical - therapy Child Colleges & universities Corneal Diseases - therapy Cytokines Disease Ear diseases Epithelium, Corneal - physiology Eye Burns - chemically induced Follow-Up Studies Health care Hospitals Humans Irrigation Ischemia Male Medical sciences Middle Aged Miscellaneous Ophthalmology Oxygen Oxygen - administration & dosage Oxygen Inhalation Therapy Oxygen therapy Pilot Projects Prospective Studies Respiratory therapy Stem cells Traumas. Diseases due to physical agents Treatment Outcome Visual Acuity Vitamin C Wound Healing - physiology Young Adult |
title | Oxygen Therapy for Acute Ocular Chemical or Thermal Burns: A Pilot Study |
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