Immunity to Trop-1, a newly identified breast cancer antigen, inhibits the growth of breast cancer in mice

Abstract This study describes the immunotherapeutic properties of vaccines that encode tumor-associated calcium signal transducer-1 (Trop-1), a newly identified breast cancer antigen, in mice with breast cancer. Previously we found that Trop-1 was over-expressed in cellular breast cancer vaccines th...

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Veröffentlicht in:	Vaccine 2010-11, Vol.28 (49), p.7757-7763
Hauptverfasser:	Lee, Byeong C, Jung, Mi Y, Cho, Daeho, O-Sullivan, InSug, Cohen, Edward P, Kim, Tae Sung
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Applied microbiology Biological and medical sciences Breast cancer Cancer therapies Cancer Vaccines - immunology Cell adhesion & migration Cell Adhesion Molecules - genetics Cell Adhesion Molecules - immunology Cell Line Colleges & universities Disease Epithelial Cell Adhesion Molecule Female Fibroblasts - immunology Fundamental and applied biological sciences. Psychology Genes H-2 Antigens Immunity Immunity, Cellular Immunization Interleukin-2 - immunology Laboratory animals Mammary Neoplasms, Experimental - immunology Mammary Neoplasms, Experimental - therapy Medical sciences Mice Mice, Inbred C3H Microbiology Patients Plasmids Spleen - immunology T-Lymphocytes, Cytotoxic - immunology Transfection Trop-1 Tumor antigen Tumors Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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