Downstream of tyrosine kinase 1 and 2 play opposing roles in CD200 receptor signaling

The CD200 receptor (CD200R) negatively regulates myeloid cells by interacting with its widely expressed ligand CD200. CD200R signals through a unique inhibitory pathway involving a direct interaction with the adaptor protein downstream of tyrosine kinase 2 (Dok2) and the subsequent recruitment and a...

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Veröffentlicht in:	The Journal of immunology (1950) 2010-12, Vol.185 (12), p.7216-7222
Hauptverfasser:	Mihrshahi, Robin, Brown, Marion H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - immunology Adaptor Proteins, Signal Transducing - metabolism Antigens, CD - genetics Antigens, CD - immunology Antigens, CD - metabolism Antigens, Surface - genetics Antigens, Surface - immunology Antigens, Surface - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - immunology DNA-Binding Proteins - metabolism Humans Models, Immunological Myeloid Cells - immunology Myeloid Cells - metabolism Nuclear Proteins - genetics Nuclear Proteins - immunology Nuclear Proteins - metabolism Oncogene Proteins - genetics Oncogene Proteins - immunology Oncogene Proteins - metabolism Phosphoproteins - genetics Phosphoproteins - immunology Phosphoproteins - metabolism Phosphorylation - genetics Phosphorylation - immunology Protein Binding - genetics Protein Binding - immunology ras GTPase-Activating Proteins - genetics ras GTPase-Activating Proteins - immunology ras GTPase-Activating Proteins - metabolism Receptors, Cell Surface - genetics Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - immunology RNA-Binding Proteins - metabolism Signal Transduction - genetics Signal Transduction - immunology U937 Cells
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