Novel thiolactone–isatin hybrids as potential antimalarial and antitubercular agents

The biological evaluation of novel thiolactone–isatin hybrids are described. Structure–activity relationships are explored and the activity profile of these derivatives revealed. The synthesis of a novel series of thiolactone–isatin hybrids led to the discovery of tetracyclic by-products which displ...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2011-04, Vol.21 (7), p.2055-2058
Hauptverfasser:	Hans, Renate H., Wiid, Ian J.F., van Helden, Paul D., Wan, Baojie, Franzblau, Scott G., Gut, Jiri, Rosenthal, Philip J., Chibale, Kelly
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalaria antimalarials Antimalarials - chemistry Antimalarials - pharmacology Antiparasitic agents Antitubercular Antitubercular Agents - chemistry Antitubercular Agents - pharmacology Biological and medical sciences byproducts Hybrids inhibitory concentration 50 Isatin Isatin - chemistry Isatin - pharmacology Lactones - chemistry Lactones - pharmacology Medical sciences Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Pharmacology. Drug treatments Plasmodium falciparum Plasmodium falciparum - drug effects Structure-Activity Relationship Thiolactone
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