Two cytokine signaling molecules co-operate to promote axonal transport and growth

The neuropoietic cytokines and their cytoplasmic signaling molecules contribute to axotomy-induced events in the nerve cell body that are beneficial to axonal regeneration. Previous studies have revealed a paradox in that, in vivo, suppressor of cytokine signaling (SOCS3) is induced in axotomized pr...

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Veröffentlicht in:	Experimental neurology 2011-04, Vol.228 (2), p.165-172
Hauptverfasser:	Miao, T., Wu, D., Wheeler, A., Wang, P., Zhang, Y., Bo, X., Yeh, J.S., Subang, M.C., Richardson, P.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adaptor Proteins, Signal Transducing - physiology Animals Axonal transport Axonal Transport - genetics Axonal Transport - physiology Biological and medical sciences Cell Line, Tumor Cells, Cultured Female Growth Inhibitors - physiology HEK293 Cells Humans JIP1 Kinesin Kinesin - metabolism Medical sciences Mice Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurite outgrowth Neurites - physiology Neurology Phosphorylation - physiology Primary sensory neuron Protein Binding - physiology Rats Rats, Sprague-Dawley Serine - metabolism Signal Transduction - physiology SOCS3 Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins - biosynthesis Suppressor of Cytokine Signaling Proteins - genetics Suppressor of Cytokine Signaling Proteins - physiology Up-Regulation - physiology
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