Sargachromanols as inhibitors of Na +/K + ATPase and isocitrate lyase

Sargachromanol D ( 4) and H ( 8) were found to be strong Na +/K + ATPase inhibitors, with IC 50 values of 3.6 and 4.6 μM, respectively. Sargachromanols A–P ( 1– 16), 16 meroterpenoids of the chromene class isolated from the brown alga Sargassum siliquastrum, were evaluated for their inhibitory activ...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2011-04, Vol.21 (7), p.1958-1961
Hauptverfasser:	Chung, Soon-Chun, Jang, Kyoung Hwa, Park, Jiyoung, Ahn, Chan-Hong, Shin, Jongheon, Oh, Ki-Bong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibacterial activity Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Benzopyrans - pharmacology Biological and medical sciences Candida albicans Candida albicans - enzymology Cerebral Cortex - enzymology Chromenes Enzyme Inhibitors - pharmacology General pharmacology Isocitrate lyase Isocitrate Lyase - antagonists & inhibitors Medical sciences Na +/K + ATPase Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Sargachromanols Sargassum siliquastrum Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Swine
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