The fungal metabolite, citrinin, inhibits lipopolysaccharide/interferon-γ-induced nitric oxide production in glomerular mesangial cells

The mycotoxin, citrinin (CTN), is a secondary metabolite of the fermented products of Monascus. The mycotoxin can either suppress or stimulate immune responses. In the present study, the immunomodulatory role of CTN in nitric oxide (NO) production, a proinflammatory mediator in the process of inflam...

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Veröffentlicht in:	International immunopharmacology 2010-12, Vol.10 (12), p.1608-1615
Hauptverfasser:	Liu, Biing-Hui, Chi, Jhih-Ying, Hsiao, Yu-Wei, Tsai, Kuen-Daw, Lee, Yi-Ju, Lin, Chia-Ching, Hsu, Shu-Ching, Yang, Shu-Mei, Lin, Ting-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western Cell Line Cell Nucleus - drug effects Cell Nucleus - enzymology Cell Nucleus - immunology Cell Nucleus - metabolism Cell Survival - drug effects Citrinin Citrinin - isolation & purification Citrinin - pharmacology Cytosol - drug effects Cytosol - enzymology Cytosol - immunology Cytosol - metabolism Data processing Electrophoretic Mobility Shift Assay gamma -Interferon Gene expression Gene Expression - drug effects Immune response Immunologic Factors - isolation & purification Immunologic Factors - pharmacology Immunomodulation Inflammation iNOS Interferon regulatory factor 1 Interferon-gamma - pharmacology Lipopolysaccharides Lipopolysaccharides - pharmacology Medical sciences MES-13 cells Mesangial cells Mesangial Cells - drug effects Mesangial Cells - immunology Mesangial Cells - metabolism Metabolites Mice Monascus Monascus - metabolism Mycotoxins NF- Kappa B protein NF-κB Nitric oxide Nitric Oxide - antagonists & inhibitors Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - antagonists & inhibitors Nitric Oxide Synthase Type II - genetics Nitric-oxide synthase Nuclear transport Pharmacology. Drug treatments Phosphorylation Reverse Transcriptase Polymerase Chain Reaction Secondary metabolites Signal transduction STAT-1α Transcription
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