Foxp3+IL-17+ T cells promote development of cancer-initiating cells in colorectal cancer

Colorectal cancer‐infiltrating Foxp3+ IL‐17+ T cells promote cancer associated cell marker expression. The pathogenesis of CRC remains to be further understood. This study was designed to elucidate the role of Foxp3+IL‐17+ T cells in the pathogenesis of CRC. Surgically removed CRC tissue was collect...

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Veröffentlicht in:	Journal of leukocyte biology 2011-01, Vol.89 (1), p.85-91
Hauptverfasser:	Yang, Shaobo, Wang, Binquan, Guan, Chunying, Wu, Benyan, Cai, Changhao, Wang, Mengwei, Zhang, Binsheng, Liu, Tao, Yang, Pingchang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Biomarkers, Tumor - metabolism Cell Hypoxia Chemokine CXCL11 - metabolism Chemotaxis Colorectal Neoplasms - enzymology Colorectal Neoplasms - immunology Colorectal Neoplasms - pathology Female Forkhead Transcription Factors - immunology Humans hypoxia Interleukin-17 - immunology Macrophages - metabolism Male Middle Aged Mitogen-Activated Protein Kinases - metabolism Neoplastic Stem Cells - immunology Neoplastic Stem Cells - pathology Proto-Oncogene Proteins c-akt - metabolism T lymphocyte T-Lymphocytes - enzymology T-Lymphocytes - immunology T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology tumor
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