Celastrol induces expression of heme oxygenase-1 through ROS/Nrf2/ARE signaling in the HaCaT cells

► In HaCaT cells, celastrol-induced HO-1 expression was dependent on ROS generation. ► ERK and p38 MAPK were major MAPK pathways responsible for celastrol-induced HO-1 expression. ► Celastrol induced Nrf2 activation. ► Celastrol can activate the ROS-ERK/p38-Nrf2-ARE signaling cascades leading to the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 2011-04, Vol.407 (3), p.535-540
Hauptverfasser:	Seo, Won Yong, Goh, Ah Ra, Ju, Sung Mi, Song, Ha Yong, Kwon, Dong-Joo, Jun, Jong-Gab, Kim, Byung Chul, Choi, Soo Young, Park, Jinseu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - metabolism Anti-Inflammatory Agents, Non-Steroidal - pharmacology Celastrol Cell Line Heme Oxygenase-1 - biosynthesis Heme Oxygenase-1 - genetics HO-1 Humans ICAM-1 IFN-γ Inflammation Intercellular Adhesion Molecule-1 - biosynthesis Interferon-gamma - pharmacology Keratinocyte Keratinocytes - drug effects Keratinocytes - metabolism NF-E2-Related Factor 2 - metabolism Nrf2 Reactive Oxygen Species - metabolism ROS Signal Transduction Triterpenes - pharmacology Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!