Curcumin activates Wnt/β-catenin signaling pathway through inhibiting the activity of GSK-3β in APPswe transfected SY5Y cells

Wnt/β-catenin signaling pathway plays an important role in the genesis and development of Alzheimer's disease. The study aims to investigate the effect of Curcumin on the expression of GSK-3β, β-catenin and CyclinD1 in vitro, which are tightly correlated with Wnt/β-catenin signaling pathway, an...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2011-04, Vol.42 (5), p.540-546
Hauptverfasser:	Zhang, Xiong, Yin, Wen-ke, Shi, Xiao-dong, Li, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - enzymology Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - physiology Amyloid Precursor Protein Secretases - genetics Amyloid Precursor Protein Secretases - physiology Aspartic Acid Endopeptidases - genetics Aspartic Acid Endopeptidases - physiology beta Catenin - metabolism Biological and medical sciences Blotting, Western Cell Line, Tumor Curcumin Curcumin - pharmacology Cyclin D1 - metabolism Fluorescent Antibody Technique General pharmacology Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 beta GSK-3β Humans Medical sciences Microscopy, Confocal Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Plasmids Reverse Transcriptase Polymerase Chain Reaction Transfection Wnt Proteins - metabolism β-Catenin
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