Retinal vascular calibre is altered in patients with rheumatoid arthritis: a biomarker of disease activity and cardiovascular risk?
Alterations in retinal vascular calibre, particularly wider venular calibre, have been independently associated with elevated markers of inflammation and cardiovascular risk in the general population. We hypothesized that retinal vascular calibre would be altered in patients with RA, who are known t...
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| Veröffentlicht in: | Rheumatology (Oxford, England) England), 2011-05, Vol.50 (5), p.939-943 |
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| creator | VAN DOORNUM, Sharon STRICKLAND, Gemma KAWASAKI, Ryo JING XIE WICKS, Ian P HODGSON, Lauren A. B WONG, Tien Y |
| description | Alterations in retinal vascular calibre, particularly wider venular calibre, have been independently associated with elevated markers of inflammation and cardiovascular risk in the general population. We hypothesized that retinal vascular calibre would be altered in patients with RA, who are known to have both elevated cardiovascular risk and chronic, systemic inflammation.
Retinal vascular calibre was measured from digital retinal photographs using computerized methods in 51 RA patients and 51 age- and gender-matched controls. Retinal vascular calibre was compared between RA and control patients with adjustment for relevant variables including cardiovascular risk factors and companion vessel calibre. The relationship between retinal venular calibre and inflammation was assessed by comparing controls and RA patients with high and lower disease activity.
Retinal venular calibre [mean (s.d.)] was significantly wider in RA patients than in controls [235.9 (24.6) vs. 211.6 (21.0) µm, P |
| doi_str_mv | 10.1093/rheumatology/keq428 |
| format | Article |
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Retinal vascular calibre was measured from digital retinal photographs using computerized methods in 51 RA patients and 51 age- and gender-matched controls. Retinal vascular calibre was compared between RA and control patients with adjustment for relevant variables including cardiovascular risk factors and companion vessel calibre. The relationship between retinal venular calibre and inflammation was assessed by comparing controls and RA patients with high and lower disease activity.
Retinal venular calibre [mean (s.d.)] was significantly wider in RA patients than in controls [235.9 (24.6) vs. 211.6 (21.0) µm, P < 0.001]. After adjustment for all relevant variables, mean venular calibre remained 20.3 µm (95% CI 10.4, 30.3) wider in RA patients compared with controls. Retinal venular calibre [mean (s.d.)] also increased with increasing levels of systemic inflammation: 211.6 (21.0) µm in controls, 232.3 (22.4) µm in RA patients with moderate or lower disease activity and 255.5 (28.3) µm in RA patients with high disease activity (P for trend < 0.0001).
This study demonstrates that RA patients have dilated retinal venular calibre, reflecting systemic inflammation and possibly increased cardiovascular risk. Longitudinal studies correlating retinal vascular calibre with subsequent cardiovascular events will clarify the clinical utility of this test in patients with RA.</description><identifier>ISSN: 1462-0324</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/keq428</identifier><identifier>PMID: 21172929</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Aged ; Arthritis, Rheumatoid - pathology ; Arthritis, Rheumatoid - physiopathology ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Biomarkers ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular Diseases - epidemiology ; Case-Control Studies ; Diseases of the osteoarticular system ; Female ; Fluorescein Angiography ; Humans ; Inflammation - pathology ; Inflammation - physiopathology ; Inflammatory joint diseases ; Male ; Medical sciences ; Middle Aged ; Retinal Vessels - pathology ; Retinal Vessels - physiopathology ; Risk Factors ; Severity of Illness Index ; Venules - pathology ; Venules - physiopathology</subject><ispartof>Rheumatology (Oxford, England), 2011-05, Vol.50 (5), p.939-943</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-3a69324bb8ead9a1d1f881f09813a1cfc56558143333cc74940585e659b5cc6d3</citedby><cites>FETCH-LOGICAL-c379t-3a69324bb8ead9a1d1f881f09813a1cfc56558143333cc74940585e659b5cc6d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24146870$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21172929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VAN DOORNUM, Sharon</creatorcontrib><creatorcontrib>STRICKLAND, Gemma</creatorcontrib><creatorcontrib>KAWASAKI, Ryo</creatorcontrib><creatorcontrib>JING XIE</creatorcontrib><creatorcontrib>WICKS, Ian P</creatorcontrib><creatorcontrib>HODGSON, Lauren A. B</creatorcontrib><creatorcontrib>WONG, Tien Y</creatorcontrib><title>Retinal vascular calibre is altered in patients with rheumatoid arthritis: a biomarker of disease activity and cardiovascular risk?</title><title>Rheumatology (Oxford, England)</title><addtitle>Rheumatology (Oxford)</addtitle><description>Alterations in retinal vascular calibre, particularly wider venular calibre, have been independently associated with elevated markers of inflammation and cardiovascular risk in the general population. We hypothesized that retinal vascular calibre would be altered in patients with RA, who are known to have both elevated cardiovascular risk and chronic, systemic inflammation.
Retinal vascular calibre was measured from digital retinal photographs using computerized methods in 51 RA patients and 51 age- and gender-matched controls. Retinal vascular calibre was compared between RA and control patients with adjustment for relevant variables including cardiovascular risk factors and companion vessel calibre. The relationship between retinal venular calibre and inflammation was assessed by comparing controls and RA patients with high and lower disease activity.
Retinal venular calibre [mean (s.d.)] was significantly wider in RA patients than in controls [235.9 (24.6) vs. 211.6 (21.0) µm, P < 0.001]. After adjustment for all relevant variables, mean venular calibre remained 20.3 µm (95% CI 10.4, 30.3) wider in RA patients compared with controls. Retinal venular calibre [mean (s.d.)] also increased with increasing levels of systemic inflammation: 211.6 (21.0) µm in controls, 232.3 (22.4) µm in RA patients with moderate or lower disease activity and 255.5 (28.3) µm in RA patients with high disease activity (P for trend < 0.0001).
This study demonstrates that RA patients have dilated retinal venular calibre, reflecting systemic inflammation and possibly increased cardiovascular risk. Longitudinal studies correlating retinal vascular calibre with subsequent cardiovascular events will clarify the clinical utility of this test in patients with RA.</description><subject>Aged</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Arthritis, Rheumatoid - physiopathology</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Case-Control Studies</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Fluorescein Angiography</subject><subject>Humans</subject><subject>Inflammation - pathology</subject><subject>Inflammation - physiopathology</subject><subject>Inflammatory joint diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Retinal Vessels - pathology</subject><subject>Retinal Vessels - physiopathology</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Venules - pathology</subject><subject>Venules - physiopathology</subject><issn>1462-0324</issn><issn>1462-0332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkU9rGzEQxUVoyb_2EwSKLqUnN9JqtZZyCSW0aSBQCMl5mZVm46nlXUfSpvjcL14FO07nMnP4zRveG8bOpPgqhVXncYHTCvIYxsfN-RKf6socsGNZN9VMKFW9289VfcROUvothNBSmUN2VEk5r2xlj9nfO8w0QODPkNwUIHIHgbqInBKHkDGi5zTwNWTCISf-h_KCv54mzyHmRaRM6YID72hcQVxi5GPPPSWEhBxcpmfKGw6DL-rR07g_FiktLz-w9z2EhB93_ZQ9_Ph-f_Vzdvvr-ubq2-3MqbnNMwWNLV66ziB4C9LL3hjZC2ukAul6pxutjaxVKefmta2FNhobbTvtXOPVKfuy1V3H8WnClNsVJYchwIDjlFrTVI2QjVaFVFvSxTGliH27jlScbVop2pfw2__Db7fhl61PO_2pW6Hf77ymXYDPO6D4h9BHGBylN64uDzNzof4BndSUiA</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>VAN DOORNUM, Sharon</creator><creator>STRICKLAND, Gemma</creator><creator>KAWASAKI, Ryo</creator><creator>JING XIE</creator><creator>WICKS, Ian P</creator><creator>HODGSON, Lauren A. B</creator><creator>WONG, Tien Y</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110501</creationdate><title>Retinal vascular calibre is altered in patients with rheumatoid arthritis: a biomarker of disease activity and cardiovascular risk?</title><author>VAN DOORNUM, Sharon ; STRICKLAND, Gemma ; KAWASAKI, Ryo ; JING XIE ; WICKS, Ian P ; HODGSON, Lauren A. B ; WONG, Tien Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-3a69324bb8ead9a1d1f881f09813a1cfc56558143333cc74940585e659b5cc6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>Arthritis, Rheumatoid - physiopathology</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Case-Control Studies</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Fluorescein Angiography</topic><topic>Humans</topic><topic>Inflammation - pathology</topic><topic>Inflammation - physiopathology</topic><topic>Inflammatory joint diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Retinal Vessels - pathology</topic><topic>Retinal Vessels - physiopathology</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Venules - pathology</topic><topic>Venules - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VAN DOORNUM, Sharon</creatorcontrib><creatorcontrib>STRICKLAND, Gemma</creatorcontrib><creatorcontrib>KAWASAKI, Ryo</creatorcontrib><creatorcontrib>JING XIE</creatorcontrib><creatorcontrib>WICKS, Ian P</creatorcontrib><creatorcontrib>HODGSON, Lauren A. B</creatorcontrib><creatorcontrib>WONG, Tien Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VAN DOORNUM, Sharon</au><au>STRICKLAND, Gemma</au><au>KAWASAKI, Ryo</au><au>JING XIE</au><au>WICKS, Ian P</au><au>HODGSON, Lauren A. B</au><au>WONG, Tien Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinal vascular calibre is altered in patients with rheumatoid arthritis: a biomarker of disease activity and cardiovascular risk?</atitle><jtitle>Rheumatology (Oxford, England)</jtitle><addtitle>Rheumatology (Oxford)</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>50</volume><issue>5</issue><spage>939</spage><epage>943</epage><pages>939-943</pages><issn>1462-0324</issn><eissn>1462-0332</eissn><abstract>Alterations in retinal vascular calibre, particularly wider venular calibre, have been independently associated with elevated markers of inflammation and cardiovascular risk in the general population. We hypothesized that retinal vascular calibre would be altered in patients with RA, who are known to have both elevated cardiovascular risk and chronic, systemic inflammation.
Retinal vascular calibre was measured from digital retinal photographs using computerized methods in 51 RA patients and 51 age- and gender-matched controls. Retinal vascular calibre was compared between RA and control patients with adjustment for relevant variables including cardiovascular risk factors and companion vessel calibre. The relationship between retinal venular calibre and inflammation was assessed by comparing controls and RA patients with high and lower disease activity.
Retinal venular calibre [mean (s.d.)] was significantly wider in RA patients than in controls [235.9 (24.6) vs. 211.6 (21.0) µm, P < 0.001]. After adjustment for all relevant variables, mean venular calibre remained 20.3 µm (95% CI 10.4, 30.3) wider in RA patients compared with controls. Retinal venular calibre [mean (s.d.)] also increased with increasing levels of systemic inflammation: 211.6 (21.0) µm in controls, 232.3 (22.4) µm in RA patients with moderate or lower disease activity and 255.5 (28.3) µm in RA patients with high disease activity (P for trend < 0.0001).
This study demonstrates that RA patients have dilated retinal venular calibre, reflecting systemic inflammation and possibly increased cardiovascular risk. Longitudinal studies correlating retinal vascular calibre with subsequent cardiovascular events will clarify the clinical utility of this test in patients with RA.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>21172929</pmid><doi>10.1093/rheumatology/keq428</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Aged Arthritis, Rheumatoid - pathology Arthritis, Rheumatoid - physiopathology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Biomarkers Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Diseases - epidemiology Case-Control Studies Diseases of the osteoarticular system Female Fluorescein Angiography Humans Inflammation - pathology Inflammation - physiopathology Inflammatory joint diseases Male Medical sciences Middle Aged Retinal Vessels - pathology Retinal Vessels - physiopathology Risk Factors Severity of Illness Index Venules - pathology Venules - physiopathology |
| title | Retinal vascular calibre is altered in patients with rheumatoid arthritis: a biomarker of disease activity and cardiovascular risk? |
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