Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin

Diabetes is a proinflammatory state. We have previously shown increased monocyte proinflammatory cytokines in patients with Type 1 and Type 2 diabetes. High glucose induces proinflammatory cytokines via epigenetic changes. Curcumin, a polyphenol responsible for the yellow color of the spice turmeric...

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Veröffentlicht in:	The Journal of nutritional biochemistry 2011-05, Vol.22 (5), p.450-458
Hauptverfasser:	Yun, Jung-Mi, Jialal, Ishwarlal, Devaraj, Sridevi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation anti-inflammatory activity Anti-Inflammatory Agents Anti-Inflammatory Agents - pharmacology Biological and medical sciences biosynthesis Blotting, Western Cell Line Chemokine CCL2 Chemokine CCL2 - metabolism chromatin color cultured cells Curcuma longa curcumin Curcumin - pharmacology Cytokines Cytokines - biosynthesis Deacetylation Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzyme-Linked Immunosorbent Assay Epigenesis, Genetic epigenetics Etiopathogenesis. Screening. Investigations. Target tissue resistance Feeding. Feeding behavior fluorescent antibody technique Fundamental and applied biological sciences. Psychology gene expression glucose Glucose - metabolism HDAC2 and NF-κB Histone Acetyltransferases Histone Acetyltransferases - metabolism histone deacetylase Histone Deacetylase 2 Histone Deacetylase 2 - metabolism Histone Deacetylases Histone Deacetylases - metabolism histones Humans inflammation interleukin-6 Interleukin-6 - metabolism mannitol Medical sciences metabolism monocytes Monocytes - metabolism NF-kappa B NF-kappa B - metabolism noninsulin-dependent diabetes mellitus p300 patients pharmacology physiopathology Reverse Transcriptase Polymerase Chain Reaction secretion spices Transcriptional Activation Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems
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