The immunohistochemical staining pattern of Gab2 correlates with distinct stages of chronic myeloid leukemia

Summary Grb2-associated binder 2 protein (Gab2) is a member of scaffold proteins, playing crucial roles in (receptor-) tyrosine kinase and cytokine signaling. Chronic myeloid leukemia cells with t(9;22)(q34;q11) express the Bcr/Abl fusion protein, which interacts with Grb2 and Gab2 signaling, thereb...

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Veröffentlicht in:	Human pathology 2011-05, Vol.42 (5), p.719-726
Hauptverfasser:	Aumann, Konrad, MD, Lassmann, Silke, PhD, Schöpflin, Anja, May, Annette M., MD, Wöhrle, Franziska U, Zeiser, Robert, MD, Waller, Cornelius F., MD, Hauschke, Dieter, PhD, Werner, Martin, MD, Brummer, Tilman, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Biological and medical sciences Blast Crisis - metabolism Blast Crisis - pathology Bone marrow Bone Marrow - metabolism Bone Marrow - pathology Bone marrow biopsy CML Enzymes Gab2 Hematologic and hematopoietic diseases Humans Immunohistochemistry Immunohistochemistry - methods Investigative techniques, diagnostic techniques (general aspects) Kinases Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Leukemia, Myeloid, Accelerated Phase - metabolism Leukemia, Myeloid, Accelerated Phase - pathology Leukemia, Myeloid, Chronic-Phase - metabolism Leukemia, Myeloid, Chronic-Phase - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Neoplasm Staging Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proteins Staining and Labeling
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