A Glucosylceramide Synthase Inhibitor Protects Rats Against the Cytotoxic Effects of Shiga Toxin 2

Postdiarrhea hemolytic uremic syndrome is the most common cause of acute renal failure in children in Argentina. Renal damage has been strongly associated with Shiga toxin (Stx), which binds to the globotriaosylceramide (Gb3) receptor on the plasma membrane of target cells. The purpose of the study...

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Veröffentlicht in:	Pediatric research 2011-05, Vol.69 (7), p.390-394
Hauptverfasser:	Silberstein, Claudia, Lucero, María S, Zotta, Elsa, Copeland, Diane P, Lingyun, Li, Repetto, Horacio A, Ibarra, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/41/1319 692/699/1585/2159/1545 692/699/1585/2762 692/700/565/1436/2185 Administration, Oral Animals Biomarkers - blood Colon - drug effects Colon - enzymology Colon - pathology Creatinine - blood Dioxanes - pharmacology Disease Models, Animal Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacology Glucosyltransferases - antagonists & inhibitors Glucosyltransferases - metabolism Hemolytic-Uremic Syndrome - chemically induced Hemolytic-Uremic Syndrome - enzymology Hemolytic-Uremic Syndrome - pathology Hemolytic-Uremic Syndrome - prevention & control Intestinal Mucosa - drug effects Intestinal Mucosa - enzymology Intestinal Mucosa - pathology Kidney - drug effects Kidney - enzymology Kidney - pathology Male Medicine Medicine & Public Health Pediatric Surgery Pediatrics Pyrrolidines - pharmacology Rats Rats, Sprague-Dawley Shiga Toxin 2 Time Factors translational-investigation Trihexosylceramides - metabolism Urea - blood
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