TGF-β induces sustained upregulation of SNAI1 and SNAI2 through Smad and non-Smad pathways in a human corneal epithelial cell line

The aim of this study was to investigate the expression changes of epithelial mesenchymal transition (EMT)-related molecules induced by TGF-β signaling in a human corneal epithelial cell line (HCECs). The cellular response to TGF-β was evaluated by immunoblotting, quantitative real-time RT-PCR, and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Investigative ophthalmology & visual science 2011-04, Vol.52 (5), p.2437-2443
Hauptverfasser:	Aomatsu, Keiichi, Arao, Tokuzo, Sugioka, Koji, Matsumoto, Kazuko, Tamura, Daisuke, Kudo, Kanae, Kaneda, Hiroyasu, Tanaka, Kaoru, Fujita, Yoshihiko, Shimomura, Yoshikazu, Nishio, Kazuto
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Cadherins - metabolism Cell Line Cell Proliferation - drug effects Dose-Response Relationship, Drug Epithelial Cells - cytology Epithelium, Corneal - cytology Epithelium, Corneal - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation - drug effects Humans Immunoblotting Mesoderm - cytology Microscopy, Fluorescence Microscopy, Phase-Contrast Reverse Transcriptase Polymerase Chain Reaction rho GTP-Binding Proteins - metabolism RNA, Messenger - metabolism Smad Proteins - metabolism Snail Family Transcription Factors Transcription Factors - genetics Transforming Growth Factor beta - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!