Randomized controlled trial of the CGRP receptor antagonist MK-3207 in the acute treatment of migraine

Background: This study evaluated the CGRP receptor antagonist MK-3207 for acute treatment of migraine. Methods: Multicenter, double-blind, randomized, placebo-controlled, parallel-group, two-stage adaptive study with two interim efficacy analyses to facilitate optimal dose selection. Migraine patien...

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Veröffentlicht in:	Cephalalgia 2011-04, Vol.31 (6), p.712-722
Hauptverfasser:	Hewitt, David J, Aurora, Sheena K, Dodick, David W, Goadsby, Peter J, Ge, Yang (Joy), Bachman, Robert, Taraborelli, Donna, Fan, Xiaoyin, Assaid, Christopher, Lines, Christopher, Ho, Tony W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Bridged Bicyclo Compounds, Heterocyclic - administration & dosage Bridged Bicyclo Compounds, Heterocyclic - adverse effects Dose-Response Relationship, Drug Female Humans Male Middle Aged Migraine Disorders - drug therapy Placebo Effect Receptors, Calcitonin Gene-Related Peptide - antagonists & inhibitors Severity of Illness Index Spiro Compounds - administration & dosage Spiro Compounds - adverse effects Treatment Outcome
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