Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models

Tumor metastasis is a leading cause of cancer-related death. Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase recruited to integrin-mediated matrix attachment sites where FAK activity is implicated in the control of cell survival, migration, and invasion. Although genetic studies suppo...

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Veröffentlicht in:	Cancer biology & therapy 2010-05, Vol.9 (10), p.778-790
Hauptverfasser:	Walsh, Colin, Tanjoni, Isabelle, Uryu, Sean, Tomar, Alok, Nam, Ju-Ock, Luo, Hong, Phillips, Angelica, Patel, Neela, Kwok, Cheni, McMahon, Gerald, Stupack, Dwayne G., Schlaepfer, David D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aminopyridines - pharmacology Aminopyridines - therapeutic use Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis - drug effects Binding Biology Bioscience Breast Neoplasms - drug therapy Breast Neoplasms - pathology Calcium Cancer Cell Cell Line, Tumor Cell Proliferation - drug effects Crk-Associated Substrate Protein - metabolism Cycle Female Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors Humans Landes Lung Neoplasms - drug therapy Lung Neoplasms - pathology Lung Neoplasms - secondary Mice Mice, Inbred BALB C Mice, Nude Mice, SCID Organogenesis Phosphorylation - drug effects Proteins Tyrosine - metabolism Xenograft Model Antitumor Assays
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