Pediatric genitourinary tumors
PURPOSE OF REVIEWTo review the 2009/2010 literature on pediatric genitourinary tumors and highlight the most significant publications. RECENT FINDINGSNew techniques such as gene expression profiling, PET, nephron-sparing surgery, and stem cell transplantation are being incorporated into contemporary...
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| Veröffentlicht in: | Current opinion in oncology 2011-05, Vol.23 (3), p.297-302 |
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| container_title | Current opinion in oncology |
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| creator | Buckley, Kevin S |
| description | PURPOSE OF REVIEWTo review the 2009/2010 literature on pediatric genitourinary tumors and highlight the most significant publications.
RECENT FINDINGSNew techniques such as gene expression profiling, PET, nephron-sparing surgery, and stem cell transplantation are being incorporated into contemporary treatments for pediatric patients with genitourinary tumors. Biologic markers are increasingly being used to help with risk stratification of patients. WT1 mutation and 11p15 loss of heterozygosity have been associated with relapse in very low-risk Wilms tumors treated with surgery alone and may help reduce the use of chemotherapy in some children. Discussion continues on the use of fusion gene status to risk stratify alveolar rhabdomyosarcoma. Meta-analysis of the use of high-dose chemotherapy with autologous hematopoetic stem cell rescue in patients with relapsed Wilms tumor and rhabdomyosarcoma suggests that some patients may benefit more from conventional salvage chemotherapy. New agents are needed for patients with high-risk and relapsed disease to improve outcomes.
SUMMARYIn general, the prognosis for patients with pediatric genitourinary tumors is favorable. The elucidation of the molecular abnormalities in these tumors is determining risk stratification, treatment strategies, and candidates for new drug development. |
| doi_str_mv | 10.1097/CCO.0b013e3283458613 |
| format | Article |
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RECENT FINDINGSNew techniques such as gene expression profiling, PET, nephron-sparing surgery, and stem cell transplantation are being incorporated into contemporary treatments for pediatric patients with genitourinary tumors. Biologic markers are increasingly being used to help with risk stratification of patients. WT1 mutation and 11p15 loss of heterozygosity have been associated with relapse in very low-risk Wilms tumors treated with surgery alone and may help reduce the use of chemotherapy in some children. Discussion continues on the use of fusion gene status to risk stratify alveolar rhabdomyosarcoma. Meta-analysis of the use of high-dose chemotherapy with autologous hematopoetic stem cell rescue in patients with relapsed Wilms tumor and rhabdomyosarcoma suggests that some patients may benefit more from conventional salvage chemotherapy. New agents are needed for patients with high-risk and relapsed disease to improve outcomes.
SUMMARYIn general, the prognosis for patients with pediatric genitourinary tumors is favorable. The elucidation of the molecular abnormalities in these tumors is determining risk stratification, treatment strategies, and candidates for new drug development.</description><identifier>ISSN: 1040-8746</identifier><identifier>EISSN: 1531-703X</identifier><identifier>DOI: 10.1097/CCO.0b013e3283458613</identifier><identifier>PMID: 21460723</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins, Inc</publisher><subject>Child ; Child, Preschool ; Humans ; Infant ; Kidney Neoplasms - diagnosis ; Kidney Neoplasms - genetics ; Kidney Neoplasms - therapy ; Male ; Rhabdomyosarcoma - diagnosis ; Rhabdomyosarcoma - genetics ; Rhabdomyosarcoma - therapy ; Testicular Neoplasms - diagnosis ; Testicular Neoplasms - genetics ; Testicular Neoplasms - therapy ; Urogenital Neoplasms - diagnosis ; Urogenital Neoplasms - genetics ; Urogenital Neoplasms - therapy ; Wilms Tumor - diagnosis ; Wilms Tumor - genetics ; Wilms Tumor - therapy</subject><ispartof>Current opinion in oncology, 2011-05, Vol.23 (3), p.297-302</ispartof><rights>2011 Lippincott Williams & Wilkins, Inc.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3553-65492ea90a542048d96d2d1113802ac821255f72cc750ec4abdaf621912e2a703</citedby><cites>FETCH-LOGICAL-c3553-65492ea90a542048d96d2d1113802ac821255f72cc750ec4abdaf621912e2a703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21460723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buckley, Kevin S</creatorcontrib><title>Pediatric genitourinary tumors</title><title>Current opinion in oncology</title><addtitle>Curr Opin Oncol</addtitle><description>PURPOSE OF REVIEWTo review the 2009/2010 literature on pediatric genitourinary tumors and highlight the most significant publications.
RECENT FINDINGSNew techniques such as gene expression profiling, PET, nephron-sparing surgery, and stem cell transplantation are being incorporated into contemporary treatments for pediatric patients with genitourinary tumors. Biologic markers are increasingly being used to help with risk stratification of patients. WT1 mutation and 11p15 loss of heterozygosity have been associated with relapse in very low-risk Wilms tumors treated with surgery alone and may help reduce the use of chemotherapy in some children. Discussion continues on the use of fusion gene status to risk stratify alveolar rhabdomyosarcoma. Meta-analysis of the use of high-dose chemotherapy with autologous hematopoetic stem cell rescue in patients with relapsed Wilms tumor and rhabdomyosarcoma suggests that some patients may benefit more from conventional salvage chemotherapy. New agents are needed for patients with high-risk and relapsed disease to improve outcomes.
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RECENT FINDINGSNew techniques such as gene expression profiling, PET, nephron-sparing surgery, and stem cell transplantation are being incorporated into contemporary treatments for pediatric patients with genitourinary tumors. Biologic markers are increasingly being used to help with risk stratification of patients. WT1 mutation and 11p15 loss of heterozygosity have been associated with relapse in very low-risk Wilms tumors treated with surgery alone and may help reduce the use of chemotherapy in some children. Discussion continues on the use of fusion gene status to risk stratify alveolar rhabdomyosarcoma. Meta-analysis of the use of high-dose chemotherapy with autologous hematopoetic stem cell rescue in patients with relapsed Wilms tumor and rhabdomyosarcoma suggests that some patients may benefit more from conventional salvage chemotherapy. New agents are needed for patients with high-risk and relapsed disease to improve outcomes.
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| fulltext | fulltext |
| identifier | ISSN: 1040-8746 |
| ispartof | Current opinion in oncology, 2011-05, Vol.23 (3), p.297-302 |
| issn | 1040-8746 1531-703X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_862268942 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Child Child, Preschool Humans Infant Kidney Neoplasms - diagnosis Kidney Neoplasms - genetics Kidney Neoplasms - therapy Male Rhabdomyosarcoma - diagnosis Rhabdomyosarcoma - genetics Rhabdomyosarcoma - therapy Testicular Neoplasms - diagnosis Testicular Neoplasms - genetics Testicular Neoplasms - therapy Urogenital Neoplasms - diagnosis Urogenital Neoplasms - genetics Urogenital Neoplasms - therapy Wilms Tumor - diagnosis Wilms Tumor - genetics Wilms Tumor - therapy |
| title | Pediatric genitourinary tumors |
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