Aldosterone paradox: differential regulation of ion transport in distal nephron
The mechanisms through which aldosterone promotes apparently opposite effects like salt reabsorption and K(+) secretion remain poorly understood. The identification, localization, and physiological analysis of ion transport systems in distal nephron have revealed an intricate network of interactions...
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| Veröffentlicht in: | Physiology (Bethesda, Md.) Md.), 2011-04, Vol.26 (2), p.115-123 |
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| container_title | Physiology (Bethesda, Md.) |
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| creator | Arroyo, Juan Pablo Ronzaud, Caroline Lagnaz, Dagmara Staub, Olivier Gamba, Gerardo |
| description | The mechanisms through which aldosterone promotes apparently opposite effects like salt reabsorption and K(+) secretion remain poorly understood. The identification, localization, and physiological analysis of ion transport systems in distal nephron have revealed an intricate network of interactions between several players, revealing the complex mechanism behind the aldosterone paradox. We review the mechanisms involved in differential regulation of ion transport that allow the fine tuning of salt and K(+) balance. |
| doi_str_mv | 10.1152/physiol.00049.2010 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1548-9213 |
| ispartof | Physiology (Bethesda, Md.), 2011-04, Vol.26 (2), p.115-123 |
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| language | eng |
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| source | MEDLINE; American Physiological Society |
| subjects | Aldosterone - physiology Animals Humans Ion Transport - physiology Kidney Tubules, Distal - physiology Potassium - metabolism Sodium Chloride - metabolism |
| title | Aldosterone paradox: differential regulation of ion transport in distal nephron |
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