Chemiluminescence as a PDT light source for microbial control
► We evaluated the in vitro feasibility for the use of chemiluminescence as a PDT light source to induce Staphylococcus aureus reduction. ► The idea of a portable, flexible and low cost light source based on chemiluminescence shows a potential clinical use. ► The PDT effect was evaluated with group...
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| Veröffentlicht in: | Journal of photochemistry and photobiology. B, Biology Biology, 2011-05, Vol.103 (2), p.87-92 |
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| container_title | Journal of photochemistry and photobiology. B, Biology |
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| creator | Ferraz, Ruy C.M.C. Fontana, Carla R. Ribeiro, Ana P. de Trindade, Flávia Z. Bartoloni, Fernando H. Baader, Josef W. Lins, Emery C. Bagnato, Vanderlei S. Kurachi, Cristina |
| description | ► We evaluated the in vitro feasibility for the use of chemiluminescence as a PDT light source to induce Staphylococcus aureus reduction. ► The idea of a portable, flexible and low cost light source based on chemiluminescence shows a potential clinical use. ► The PDT effect was evaluated with group (PS+L+) and it presented a significant bacterial reduction compared to group (PS+L-).
The photodynamic therapy (PDT) is a combination of using a photosensitizer agent, light and oxygen that can cause oxidative cellular damage. This technique is applied in several cases, including for microbial control. The most extensively studied light sources for this purpose are lasers and LED-based systems. Few studies treat alternative light sources based PDT. Sources which present flexibility, portability and economic advantages are of great interest. In this study, we evaluated the
in vitro feasibility for the use of chemiluminescence as a PDT light source to induce
Staphylococcus aureus reduction. The Photogem® concentration varied from 0 to 75
μg/ml and the illumination time varied from 60
min to 240
min.
The long exposure time was necessary due to the low irradiance achieved with chemiluminescence reaction at μW/cm
2 level. The results demonstrated an effective microbial reduction of around 98% for the highest photosensitizer concentration and light dose. These data suggest the potential use of chemiluminescence as a light source for PDT microbial control, with advantages in terms of flexibility, when compared with conventional sources. |
| doi_str_mv | 10.1016/j.jphotobiol.2011.01.018 |
| format | Article |
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The photodynamic therapy (PDT) is a combination of using a photosensitizer agent, light and oxygen that can cause oxidative cellular damage. This technique is applied in several cases, including for microbial control. The most extensively studied light sources for this purpose are lasers and LED-based systems. Few studies treat alternative light sources based PDT. Sources which present flexibility, portability and economic advantages are of great interest. In this study, we evaluated the
in vitro feasibility for the use of chemiluminescence as a PDT light source to induce
Staphylococcus aureus reduction. The Photogem® concentration varied from 0 to 75
μg/ml and the illumination time varied from 60
min to 240
min.
The long exposure time was necessary due to the low irradiance achieved with chemiluminescence reaction at μW/cm
2 level. The results demonstrated an effective microbial reduction of around 98% for the highest photosensitizer concentration and light dose. These data suggest the potential use of chemiluminescence as a light source for PDT microbial control, with advantages in terms of flexibility, when compared with conventional sources.</description><identifier>ISSN: 1011-1344</identifier><identifier>EISSN: 1873-2682</identifier><identifier>DOI: 10.1016/j.jphotobiol.2011.01.018</identifier><identifier>PMID: 21349738</identifier><language>eng</language><publisher>Switzerland: Elsevier B.V</publisher><subject>Alkynes - chemistry ; Anthracenes - chemistry ; Chemiluminescence ; Data processing ; Economics ; exposure duration ; Illumination ; in vitro studies ; Irradiance ; Lasers ; Light effects ; light intensity ; lighting ; Low intensity irradiation ; Luminescence ; Microbial control ; Oxalates - chemistry ; Oxygen ; photobiology ; photochemistry ; Photochemotherapy - methods ; Photodynamic therapy ; Photosensitizing Agents - pharmacology ; Staphylococcal Infections - drug therapy ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; therapeutics</subject><ispartof>Journal of photochemistry and photobiology. B, Biology, 2011-05, Vol.103 (2), p.87-92</ispartof><rights>2011 Elsevier B.V.</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-1862acd6a3be7a7ca47a18c7dea68becfa09ef1aa7caf1875b9e4e845cf061263</citedby><cites>FETCH-LOGICAL-c430t-1862acd6a3be7a7ca47a18c7dea68becfa09ef1aa7caf1875b9e4e845cf061263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jphotobiol.2011.01.018$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21349738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferraz, Ruy C.M.C.</creatorcontrib><creatorcontrib>Fontana, Carla R.</creatorcontrib><creatorcontrib>Ribeiro, Ana P. de</creatorcontrib><creatorcontrib>Trindade, Flávia Z.</creatorcontrib><creatorcontrib>Bartoloni, Fernando H.</creatorcontrib><creatorcontrib>Baader, Josef W.</creatorcontrib><creatorcontrib>Lins, Emery C.</creatorcontrib><creatorcontrib>Bagnato, Vanderlei S.</creatorcontrib><creatorcontrib>Kurachi, Cristina</creatorcontrib><title>Chemiluminescence as a PDT light source for microbial control</title><title>Journal of photochemistry and photobiology. B, Biology</title><addtitle>J Photochem Photobiol B</addtitle><description>► We evaluated the in vitro feasibility for the use of chemiluminescence as a PDT light source to induce Staphylococcus aureus reduction. ► The idea of a portable, flexible and low cost light source based on chemiluminescence shows a potential clinical use. ► The PDT effect was evaluated with group (PS+L+) and it presented a significant bacterial reduction compared to group (PS+L-).
The photodynamic therapy (PDT) is a combination of using a photosensitizer agent, light and oxygen that can cause oxidative cellular damage. This technique is applied in several cases, including for microbial control. The most extensively studied light sources for this purpose are lasers and LED-based systems. Few studies treat alternative light sources based PDT. Sources which present flexibility, portability and economic advantages are of great interest. In this study, we evaluated the
in vitro feasibility for the use of chemiluminescence as a PDT light source to induce
Staphylococcus aureus reduction. The Photogem® concentration varied from 0 to 75
μg/ml and the illumination time varied from 60
min to 240
min.
The long exposure time was necessary due to the low irradiance achieved with chemiluminescence reaction at μW/cm
2 level. The results demonstrated an effective microbial reduction of around 98% for the highest photosensitizer concentration and light dose. These data suggest the potential use of chemiluminescence as a light source for PDT microbial control, with advantages in terms of flexibility, when compared with conventional sources.</description><subject>Alkynes - chemistry</subject><subject>Anthracenes - chemistry</subject><subject>Chemiluminescence</subject><subject>Data processing</subject><subject>Economics</subject><subject>exposure duration</subject><subject>Illumination</subject><subject>in vitro studies</subject><subject>Irradiance</subject><subject>Lasers</subject><subject>Light effects</subject><subject>light intensity</subject><subject>lighting</subject><subject>Low intensity irradiation</subject><subject>Luminescence</subject><subject>Microbial control</subject><subject>Oxalates - chemistry</subject><subject>Oxygen</subject><subject>photobiology</subject><subject>photochemistry</subject><subject>Photochemotherapy - methods</subject><subject>Photodynamic therapy</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>therapeutics</subject><issn>1011-1344</issn><issn>1873-2682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLxDAQx4Morq5-Be1NL12TtE3Tgwddn7CgoJ5Dmk7dLO1mTVrBb--U-rhpGEiY-c3rH0IiRmeMMnG2mq02S9e50rpmxiljMzqY3CJ7TOZJzIXk2_jGSMySNJ2Q_RBWFE8m8l0y4egs8kTukfP5Elrb9K1dQzCwNhDpEOno8eo5auzrsouC6z16a-ej1hqPPXUTGbfuvGsOyE6tmwCHX_eUvNxcP8_v4sXD7f38YhGbNKFdzKTg2lRCJyXkOjc6zTWTJq9AC1mCqTUtoGZ6CNW4QFYWkIJMM1NTwbhIpuRkrLvx7q2H0KnW4rRNo9fg-qCwPq7GRYbk6Z8ko5xnghdpiqgcUVwqBA-12njbav-BkBpkViv1K7MaZFZ0MImpR19d-rKF6ifxW1cEjkeg1k7pV2-DennCCgK_gCVZwZG4HAlA3d4teBWMHfSvrAfTqcrZ_-f4BKbZnLY</recordid><startdate>20110503</startdate><enddate>20110503</enddate><creator>Ferraz, Ruy C.M.C.</creator><creator>Fontana, Carla R.</creator><creator>Ribeiro, Ana P. de</creator><creator>Trindade, Flávia Z.</creator><creator>Bartoloni, Fernando H.</creator><creator>Baader, Josef W.</creator><creator>Lins, Emery C.</creator><creator>Bagnato, Vanderlei S.</creator><creator>Kurachi, Cristina</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20110503</creationdate><title>Chemiluminescence as a PDT light source for microbial control</title><author>Ferraz, Ruy C.M.C. ; Fontana, Carla R. ; Ribeiro, Ana P. de ; Trindade, Flávia Z. ; Bartoloni, Fernando H. ; Baader, Josef W. ; Lins, Emery C. ; Bagnato, Vanderlei S. ; Kurachi, Cristina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-1862acd6a3be7a7ca47a18c7dea68becfa09ef1aa7caf1875b9e4e845cf061263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Alkynes - chemistry</topic><topic>Anthracenes - chemistry</topic><topic>Chemiluminescence</topic><topic>Data processing</topic><topic>Economics</topic><topic>exposure duration</topic><topic>Illumination</topic><topic>in vitro studies</topic><topic>Irradiance</topic><topic>Lasers</topic><topic>Light effects</topic><topic>light intensity</topic><topic>lighting</topic><topic>Low intensity irradiation</topic><topic>Luminescence</topic><topic>Microbial control</topic><topic>Oxalates - chemistry</topic><topic>Oxygen</topic><topic>photobiology</topic><topic>photochemistry</topic><topic>Photochemotherapy - methods</topic><topic>Photodynamic therapy</topic><topic>Photosensitizing Agents - pharmacology</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - drug effects</topic><topic>therapeutics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferraz, Ruy C.M.C.</creatorcontrib><creatorcontrib>Fontana, Carla R.</creatorcontrib><creatorcontrib>Ribeiro, Ana P. de</creatorcontrib><creatorcontrib>Trindade, Flávia Z.</creatorcontrib><creatorcontrib>Bartoloni, Fernando H.</creatorcontrib><creatorcontrib>Baader, Josef W.</creatorcontrib><creatorcontrib>Lins, Emery C.</creatorcontrib><creatorcontrib>Bagnato, Vanderlei S.</creatorcontrib><creatorcontrib>Kurachi, Cristina</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of photochemistry and photobiology. 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B, Biology</jtitle><addtitle>J Photochem Photobiol B</addtitle><date>2011-05-03</date><risdate>2011</risdate><volume>103</volume><issue>2</issue><spage>87</spage><epage>92</epage><pages>87-92</pages><issn>1011-1344</issn><eissn>1873-2682</eissn><abstract>► We evaluated the in vitro feasibility for the use of chemiluminescence as a PDT light source to induce Staphylococcus aureus reduction. ► The idea of a portable, flexible and low cost light source based on chemiluminescence shows a potential clinical use. ► The PDT effect was evaluated with group (PS+L+) and it presented a significant bacterial reduction compared to group (PS+L-).
The photodynamic therapy (PDT) is a combination of using a photosensitizer agent, light and oxygen that can cause oxidative cellular damage. This technique is applied in several cases, including for microbial control. The most extensively studied light sources for this purpose are lasers and LED-based systems. Few studies treat alternative light sources based PDT. Sources which present flexibility, portability and economic advantages are of great interest. In this study, we evaluated the
in vitro feasibility for the use of chemiluminescence as a PDT light source to induce
Staphylococcus aureus reduction. The Photogem® concentration varied from 0 to 75
μg/ml and the illumination time varied from 60
min to 240
min.
The long exposure time was necessary due to the low irradiance achieved with chemiluminescence reaction at μW/cm
2 level. The results demonstrated an effective microbial reduction of around 98% for the highest photosensitizer concentration and light dose. These data suggest the potential use of chemiluminescence as a light source for PDT microbial control, with advantages in terms of flexibility, when compared with conventional sources.</abstract><cop>Switzerland</cop><pub>Elsevier B.V</pub><pmid>21349738</pmid><doi>10.1016/j.jphotobiol.2011.01.018</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of photochemistry and photobiology. B, Biology, 2011-05, Vol.103 (2), p.87-92 |
| issn | 1011-1344 1873-2682 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_862005265 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alkynes - chemistry Anthracenes - chemistry Chemiluminescence Data processing Economics exposure duration Illumination in vitro studies Irradiance Lasers Light effects light intensity lighting Low intensity irradiation Luminescence Microbial control Oxalates - chemistry Oxygen photobiology photochemistry Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - pharmacology Staphylococcal Infections - drug therapy Staphylococcus aureus Staphylococcus aureus - drug effects therapeutics |
| title | Chemiluminescence as a PDT light source for microbial control |
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