Antinociceptive activity of ethanolic extract and isolated compounds of Urtica circularis
Urtica circularis (Hicken) Sorarú is a medicinal plant commonly used in traditional medicine to relieve pain in inflammatory processes. In the present study, the in vivo antinociceptive effect of Urtica circularis ethanolic extract and its isolated compounds has been investigated. Antinociceptive ac...
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| Veröffentlicht in: | Journal of ethnopharmacology 2011-04, Vol.134 (3), p.733-738 |
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| creator | Gorzalczany, S. Marrassini, C. Miño, J. Acevedo, C. Ferraro, G. |
| description | Urtica circularis (Hicken) Sorarú is a medicinal plant commonly used in traditional medicine to relieve pain in inflammatory processes.
In the present study, the in vivo antinociceptive effect of Urtica circularis ethanolic extract and its isolated compounds has been investigated.
Antinociceptive activity was evaluated through writhing, formalin and hot plate tests in mice. The phytochemical analysis was performed.
The extract produced significant inhibition on nociception induced by acetic acid (ED50: 72.2mg/kg, i.p.) and formalin (ED50: 15.8mg/kg, i.p.) administered intraperitoneally and also orally. Atropine diminished the activity of the extract in the acetic acid test. In this model, at dose of 10mg/kg i.p., vitexin was the most active of the isolated compounds (inhibition of 91%), and chlorogenic acid, caffeic acid and vicenin-2 (6,8-di-C-glucosyl apigenin) produced an inhibition of 72%, 41% and 41%, respectively, whereas apigenin did not show any activity.
These results suggest that Urtica circularis extract produced antinociception possibly related to the presence of vitexin, chlorogenic, caffeic acid and vicenin-2. The activation of cholinergic systems seems to be involved in the mechanism of antinociception of the extract. |
| doi_str_mv | 10.1016/j.jep.2011.01.025 |
| format | Article |
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In the present study, the in vivo antinociceptive effect of Urtica circularis ethanolic extract and its isolated compounds has been investigated.
Antinociceptive activity was evaluated through writhing, formalin and hot plate tests in mice. The phytochemical analysis was performed.
The extract produced significant inhibition on nociception induced by acetic acid (ED50: 72.2mg/kg, i.p.) and formalin (ED50: 15.8mg/kg, i.p.) administered intraperitoneally and also orally. Atropine diminished the activity of the extract in the acetic acid test. In this model, at dose of 10mg/kg i.p., vitexin was the most active of the isolated compounds (inhibition of 91%), and chlorogenic acid, caffeic acid and vicenin-2 (6,8-di-C-glucosyl apigenin) produced an inhibition of 72%, 41% and 41%, respectively, whereas apigenin did not show any activity.
These results suggest that Urtica circularis extract produced antinociception possibly related to the presence of vitexin, chlorogenic, caffeic acid and vicenin-2. The activation of cholinergic systems seems to be involved in the mechanism of antinociception of the extract.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2011.01.025</identifier><identifier>PMID: 21277970</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Analgesics - pharmacology ; Animals ; Antinociceptive activity ; Biological and medical sciences ; Caffeic acid ; Chlorogenic acid ; Chromatography, High Pressure Liquid ; Drug Evaluation, Preclinical ; Ethanol - chemistry ; General pharmacology ; Medical sciences ; Mice ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Stomach - drug effects ; Urtica circularis ; Urticaceae - chemistry ; Vicenin-2 ; Vitexin</subject><ispartof>Journal of ethnopharmacology, 2011-04, Vol.134 (3), p.733-738</ispartof><rights>2011 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-3202a84be71f713b54f6f6c3bc68d906fdabf63da3cb2694664fad4c77cd13a43</citedby><cites>FETCH-LOGICAL-c448t-3202a84be71f713b54f6f6c3bc68d906fdabf63da3cb2694664fad4c77cd13a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874111000390$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24043162$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21277970$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gorzalczany, S.</creatorcontrib><creatorcontrib>Marrassini, C.</creatorcontrib><creatorcontrib>Miño, J.</creatorcontrib><creatorcontrib>Acevedo, C.</creatorcontrib><creatorcontrib>Ferraro, G.</creatorcontrib><title>Antinociceptive activity of ethanolic extract and isolated compounds of Urtica circularis</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Urtica circularis (Hicken) Sorarú is a medicinal plant commonly used in traditional medicine to relieve pain in inflammatory processes.
In the present study, the in vivo antinociceptive effect of Urtica circularis ethanolic extract and its isolated compounds has been investigated.
Antinociceptive activity was evaluated through writhing, formalin and hot plate tests in mice. The phytochemical analysis was performed.
The extract produced significant inhibition on nociception induced by acetic acid (ED50: 72.2mg/kg, i.p.) and formalin (ED50: 15.8mg/kg, i.p.) administered intraperitoneally and also orally. Atropine diminished the activity of the extract in the acetic acid test. In this model, at dose of 10mg/kg i.p., vitexin was the most active of the isolated compounds (inhibition of 91%), and chlorogenic acid, caffeic acid and vicenin-2 (6,8-di-C-glucosyl apigenin) produced an inhibition of 72%, 41% and 41%, respectively, whereas apigenin did not show any activity.
These results suggest that Urtica circularis extract produced antinociception possibly related to the presence of vitexin, chlorogenic, caffeic acid and vicenin-2. The activation of cholinergic systems seems to be involved in the mechanism of antinociception of the extract.</description><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Antinociceptive activity</subject><subject>Biological and medical sciences</subject><subject>Caffeic acid</subject><subject>Chlorogenic acid</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Drug Evaluation, Preclinical</subject><subject>Ethanol - chemistry</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Stomach - drug effects</subject><subject>Urtica circularis</subject><subject>Urticaceae - chemistry</subject><subject>Vicenin-2</subject><subject>Vitexin</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9LHDEUx0Npqav2D-ilzKV4mjW_NpnFk4hVQfBSD55C5uWFZpmdTJOM6H9vlt3Wm_CFd3if9-XxIeQ7o0tGmTrfLDc4LTllbElr-OoTWbBO81avtPhMFlToru20ZEfkOOcNpVQzSb-SI8641mtNF-TpcixhjBAApxKesbFQRyivTfQNlj92jEOABl9KqpvGjq4JOQ62oGsgbqc4jy7v2MdUAtgGQoJ5sCnkU_LF2yHjt8M8IY-_rn9f3bb3Dzd3V5f3LUjZlVZwym0ne9TMayb6lfTKKxA9qM6tqfLO9l4JZwX0XK2lUtJbJ0FrcExYKU7I2b53SvHvjLmYbciAw2BHjHM2nWJ6LbUWlWR7ElLMOaE3Uwpbm14No2Yn1GxMFWp2Qg2t4at68-PQPvdbdP8v_hmswM8DYDPYwSc7QsjvnKRSMMUrd7HnsLp4DphMhoAjoAsJoRgXwwdvvAGQh5So</recordid><startdate>20110412</startdate><enddate>20110412</enddate><creator>Gorzalczany, S.</creator><creator>Marrassini, C.</creator><creator>Miño, J.</creator><creator>Acevedo, C.</creator><creator>Ferraro, G.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110412</creationdate><title>Antinociceptive activity of ethanolic extract and isolated compounds of Urtica circularis</title><author>Gorzalczany, S. ; Marrassini, C. ; Miño, J. ; Acevedo, C. ; Ferraro, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-3202a84be71f713b54f6f6c3bc68d906fdabf63da3cb2694664fad4c77cd13a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Antinociceptive activity</topic><topic>Biological and medical sciences</topic><topic>Caffeic acid</topic><topic>Chlorogenic acid</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Drug Evaluation, Preclinical</topic><topic>Ethanol - chemistry</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Stomach - drug effects</topic><topic>Urtica circularis</topic><topic>Urticaceae - chemistry</topic><topic>Vicenin-2</topic><topic>Vitexin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gorzalczany, S.</creatorcontrib><creatorcontrib>Marrassini, C.</creatorcontrib><creatorcontrib>Miño, J.</creatorcontrib><creatorcontrib>Acevedo, C.</creatorcontrib><creatorcontrib>Ferraro, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gorzalczany, S.</au><au>Marrassini, C.</au><au>Miño, J.</au><au>Acevedo, C.</au><au>Ferraro, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antinociceptive activity of ethanolic extract and isolated compounds of Urtica circularis</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2011-04-12</date><risdate>2011</risdate><volume>134</volume><issue>3</issue><spage>733</spage><epage>738</epage><pages>733-738</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Urtica circularis (Hicken) Sorarú is a medicinal plant commonly used in traditional medicine to relieve pain in inflammatory processes.
In the present study, the in vivo antinociceptive effect of Urtica circularis ethanolic extract and its isolated compounds has been investigated.
Antinociceptive activity was evaluated through writhing, formalin and hot plate tests in mice. The phytochemical analysis was performed.
The extract produced significant inhibition on nociception induced by acetic acid (ED50: 72.2mg/kg, i.p.) and formalin (ED50: 15.8mg/kg, i.p.) administered intraperitoneally and also orally. Atropine diminished the activity of the extract in the acetic acid test. In this model, at dose of 10mg/kg i.p., vitexin was the most active of the isolated compounds (inhibition of 91%), and chlorogenic acid, caffeic acid and vicenin-2 (6,8-di-C-glucosyl apigenin) produced an inhibition of 72%, 41% and 41%, respectively, whereas apigenin did not show any activity.
These results suggest that Urtica circularis extract produced antinociception possibly related to the presence of vitexin, chlorogenic, caffeic acid and vicenin-2. The activation of cholinergic systems seems to be involved in the mechanism of antinociception of the extract.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>21277970</pmid><doi>10.1016/j.jep.2011.01.025</doi><tpages>6</tpages></addata></record> |
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| subjects | Analgesics - pharmacology Animals Antinociceptive activity Biological and medical sciences Caffeic acid Chlorogenic acid Chromatography, High Pressure Liquid Drug Evaluation, Preclinical Ethanol - chemistry General pharmacology Medical sciences Mice Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - pharmacology Stomach - drug effects Urtica circularis Urticaceae - chemistry Vicenin-2 Vitexin |
| title | Antinociceptive activity of ethanolic extract and isolated compounds of Urtica circularis |
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