Pattern Recognition with a Fibril-Specific Antibody Fragment Reveals the Surface Variability of Natural Amyloid Fibrils

Amyloid immunotherapy has led to the rise of antibodies, which target amyloid fibrils or structural precursors of fibrils, based on their specific conformational properties. Recently, we reported the biotechnological generation of the B10 antibody fragment, which provides conformation-specific bindi...

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Veröffentlicht in:Journal of molecular biology 2011-05, Vol.408 (3), p.529-540
Hauptverfasser: Haupt, Christian, Bereza, Magdalena, Kumar, Senthil T., Kieninger, Barbara, Morgado, Isabel, Hortschansky, Peter, Fritz, Günter, Röcken, Christoph, Horn, Uwe, Fändrich, Marcus
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