Aberrant response to commensal Bacteroides thetaiotaomicron in Crohn's disease: An ex vivo human organ culture study

Background: Human ex vivo evidence indicating that an inappropriate immune response(s) to nonpathogenic bacteria contributes to disease pathogenesis in pediatric Crohn's disease (CD) is limited. The aim of the present study was to compare and contrast the early innate immune response of pediatr...

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Veröffentlicht in:	Inflammatory bowel diseases 2011-05, Vol.17 (5), p.1201-1208
Hauptverfasser:	Edwards, L.A., Lucas, M., Edwards, E.A., Torrente, F., Heuschkel, R.B., Klein, N.J., Murch, S.H., Bajaj‐Elliott, M., Phillips, A.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteroides - immunology Bacteroides thetaiotaomicron Biopsy chemokines Child Colon Colon - immunology Colon - microbiology Colon - pathology Commensals Crohn Disease - immunology Crohn Disease - microbiology Crohn Disease - pathology Crohn's disease Data processing Enzyme-linked immunosorbent assay Escherichia coli Gene Expression - drug effects Gene Expression - immunology Humans Ileum Immune response infectious agents in IBD Inflammatory bowel diseases innate immune system in IBD Interleukin 8 Interleukin-1beta - immunology Interleukin-1beta - pharmacology Interleukin-8 - genetics Interleukin-8 - immunology Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Intestine Lactobacillus Metagenome - immunology microbial epithelial cell interactions mRNA Mucosa mucosal immunology Organ culture Organ Culture Techniques Pediatrics Polymerase chain reaction Probiotics
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