Effect of drinking compared with eating sugars or whey protein on short-term appetite and food intake
Background: It is hypothesized that a solid form of food or food components suppresses subjective appetite and short-term food intake (FI) more than a liquid form. Objective: To compare the effect of eating solid vs drinking liquid forms of gelatin, sucrose and its component mixtures, and whey prote...
Gespeichert in:
Veröffentlicht in: | International Journal of Obesity 2011-04, Vol.35 (4), p.562-569 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 569 |
---|---|
container_issue | 4 |
container_start_page | 562 |
container_title | International Journal of Obesity |
container_volume | 35 |
creator | Akhavan, T Luhovyy, B.L Anderson, G.H |
description | Background: It is hypothesized that a solid form of food or food components suppresses subjective appetite and short-term food intake (FI) more than a liquid form. Objective: To compare the effect of eating solid vs drinking liquid forms of gelatin, sucrose and its component mixtures, and whey protein, on subjective appetite and FI in young men. Design and subjects: A randomized crossover design was used in three experiments in which the subjects were healthy males of normal weight. Solid and liquid forms of gelatin (6g) (experiment 1, n=14), sucrose (75g) and a mixture of 50% glucose/50% fructose (G50:F50) (experiment 2, n=15), and acid and sweet whey protein (50g) (experiment 3, n=14) were compared. The controls were water (experiments 1 and 3) and calorie-free sweetened water with gelatin (sweet gelatin, experiment 1) or calorie-free sweetened water (sweet control, experiment 2). Subjective average appetite was measured by visual analog scales over 1h and ad libitum FI was measured 1h after treatment consumption. Results: Average appetite area under the curve was not different between solid and liquid forms of sugars, but was larger, indicating greater satiety for solid compared with liquid forms of gelatin and sweet, but not acid whey protein. The FI was not different from that of control because of solid or liquid sugars or gelatin treatments. However, both solid and liquid forms of whey protein, with no difference among them, suppressed FI compared with control (P |
doi_str_mv | 10.1038/ijo.2010.163 |
format | Article |
fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_861791283</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A254678507</galeid><sourcerecordid>A254678507</sourcerecordid><originalsourceid>FETCH-LOGICAL-c570t-71f5ed64a28cbd573a432857fc47e9b701a058205786a09f9d9caba2421aed933</originalsourceid><addsrcrecordid>eNp10k1v1DAQBuAIgeiycOMMFgi4kMWx4zg5VlX5kCpxgJ6jWWec9Taxt7ajqv8eR1laikA5RLEfj8d-k2UvC7opKK8_mb3bMDp_VfxRtipKWeWibOTjbEU5lTkVlTjJnoWwp5QKQdnT7IRRybmo2SrDc61RReI06byxV8b2RLnxAB47cmPijiDEeTBMPfhAnCc3O7wlB-8iGkucJWHnfMwj-pHA4YDRRCRgO6Kd64ixEa7wefZEwxDwxfG9zi4_n_88-5pffP_y7ez0IldC0pjLQgvsqhJYrbadkBxKzmohtSolNltJC6CpaypkXQFtdNM1CrbASlYAdg3n6-zDUje1dz1hiO1ogsJhAItuCm1dFbIpWD3LN3_JvZu8Tc3NiDeNoEVCbxfUw4CtsdpFD2ou2Z4yUVayFuki19nmHyo9HY5GOYvapPEHC97_sWCHMMRdcMMUjbPhIfy4QOVdCB51e_BmBH_bFrSdw29T-O0cfpvCT_zV8UzTdsTuDv9OO4F3RwBBwaA9WGXCvStpRVlFk8sXF9KU7dHfX85_NiaLtxAnj3cFE5rNQl4vRINrofdp28sfaVKkn1LyQgr-C3mC1zs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>861399501</pqid></control><display><type>article</type><title>Effect of drinking compared with eating sugars or whey protein on short-term appetite and food intake</title><source>MEDLINE</source><source>Nature Journals Online</source><source>EZB-FREE-00999 freely available EZB journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>Akhavan, T ; Luhovyy, B.L ; Anderson, G.H</creator><creatorcontrib>Akhavan, T ; Luhovyy, B.L ; Anderson, G.H</creatorcontrib><description>Background: It is hypothesized that a solid form of food or food components suppresses subjective appetite and short-term food intake (FI) more than a liquid form. Objective: To compare the effect of eating solid vs drinking liquid forms of gelatin, sucrose and its component mixtures, and whey protein, on subjective appetite and FI in young men. Design and subjects: A randomized crossover design was used in three experiments in which the subjects were healthy males of normal weight. Solid and liquid forms of gelatin (6g) (experiment 1, n=14), sucrose (75g) and a mixture of 50% glucose/50% fructose (G50:F50) (experiment 2, n=15), and acid and sweet whey protein (50g) (experiment 3, n=14) were compared. The controls were water (experiments 1 and 3) and calorie-free sweetened water with gelatin (sweet gelatin, experiment 1) or calorie-free sweetened water (sweet control, experiment 2). Subjective average appetite was measured by visual analog scales over 1h and ad libitum FI was measured 1h after treatment consumption. Results: Average appetite area under the curve was not different between solid and liquid forms of sugars, but was larger, indicating greater satiety for solid compared with liquid forms of gelatin and sweet, but not acid whey protein. The FI was not different from that of control because of solid or liquid sugars or gelatin treatments. However, both solid and liquid forms of whey protein, with no difference among them, suppressed FI compared with control (P<0.05). Conclusion: Macronutrient composition is more important than physical state of foods in determining subjective appetite and FI.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/ijo.2010.163</identifier><identifier>PMID: 20733582</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group</publisher><subject>631/443/319/1488 ; Adult ; Appetite ; Appetite Regulation ; Beverages ; Biological and medical sciences ; Calories ; cross-over studies ; Design ; Diet ; Dietary Carbohydrates - administration & dosage ; drinking ; Drinking - physiology ; Eating - physiology ; Energy ; Energy Intake ; Epidemiology ; Experiments ; Food ; Food habits ; food intake ; foods ; fructose ; Fruit juices ; gelatin ; Health aspects ; Health Promotion and Disease Prevention ; Humans ; Hypotheses ; Internal Medicine ; Male ; Males ; Medical research ; Medical sciences ; Medicine ; Medicine & Public Health ; men ; Metabolic Diseases ; Milk Proteins - administration & dosage ; Obesity ; original-article ; Proteins ; Public Health ; Satiation - physiology ; satiety ; sucrose ; Sugar ; whey protein ; Whey Proteins ; Young Adult</subject><ispartof>International Journal of Obesity, 2011-04, Vol.35 (4), p.562-569</ispartof><rights>Macmillan Publishers Limited 2011</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Apr 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-71f5ed64a28cbd573a432857fc47e9b701a058205786a09f9d9caba2421aed933</citedby><cites>FETCH-LOGICAL-c570t-71f5ed64a28cbd573a432857fc47e9b701a058205786a09f9d9caba2421aed933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ijo.2010.163$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ijo.2010.163$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2725,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24060260$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20733582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akhavan, T</creatorcontrib><creatorcontrib>Luhovyy, B.L</creatorcontrib><creatorcontrib>Anderson, G.H</creatorcontrib><title>Effect of drinking compared with eating sugars or whey protein on short-term appetite and food intake</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Background: It is hypothesized that a solid form of food or food components suppresses subjective appetite and short-term food intake (FI) more than a liquid form. Objective: To compare the effect of eating solid vs drinking liquid forms of gelatin, sucrose and its component mixtures, and whey protein, on subjective appetite and FI in young men. Design and subjects: A randomized crossover design was used in three experiments in which the subjects were healthy males of normal weight. Solid and liquid forms of gelatin (6g) (experiment 1, n=14), sucrose (75g) and a mixture of 50% glucose/50% fructose (G50:F50) (experiment 2, n=15), and acid and sweet whey protein (50g) (experiment 3, n=14) were compared. The controls were water (experiments 1 and 3) and calorie-free sweetened water with gelatin (sweet gelatin, experiment 1) or calorie-free sweetened water (sweet control, experiment 2). Subjective average appetite was measured by visual analog scales over 1h and ad libitum FI was measured 1h after treatment consumption. Results: Average appetite area under the curve was not different between solid and liquid forms of sugars, but was larger, indicating greater satiety for solid compared with liquid forms of gelatin and sweet, but not acid whey protein. The FI was not different from that of control because of solid or liquid sugars or gelatin treatments. However, both solid and liquid forms of whey protein, with no difference among them, suppressed FI compared with control (P<0.05). Conclusion: Macronutrient composition is more important than physical state of foods in determining subjective appetite and FI.</description><subject>631/443/319/1488</subject><subject>Adult</subject><subject>Appetite</subject><subject>Appetite Regulation</subject><subject>Beverages</subject><subject>Biological and medical sciences</subject><subject>Calories</subject><subject>cross-over studies</subject><subject>Design</subject><subject>Diet</subject><subject>Dietary Carbohydrates - administration & dosage</subject><subject>drinking</subject><subject>Drinking - physiology</subject><subject>Eating - physiology</subject><subject>Energy</subject><subject>Energy Intake</subject><subject>Epidemiology</subject><subject>Experiments</subject><subject>Food</subject><subject>Food habits</subject><subject>food intake</subject><subject>foods</subject><subject>fructose</subject><subject>Fruit juices</subject><subject>gelatin</subject><subject>Health aspects</subject><subject>Health Promotion and Disease Prevention</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Males</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>men</subject><subject>Metabolic Diseases</subject><subject>Milk Proteins - administration & dosage</subject><subject>Obesity</subject><subject>original-article</subject><subject>Proteins</subject><subject>Public Health</subject><subject>Satiation - physiology</subject><subject>satiety</subject><subject>sucrose</subject><subject>Sugar</subject><subject>whey protein</subject><subject>Whey Proteins</subject><subject>Young Adult</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp10k1v1DAQBuAIgeiycOMMFgi4kMWx4zg5VlX5kCpxgJ6jWWec9Taxt7ajqv8eR1laikA5RLEfj8d-k2UvC7opKK8_mb3bMDp_VfxRtipKWeWibOTjbEU5lTkVlTjJnoWwp5QKQdnT7IRRybmo2SrDc61RReI06byxV8b2RLnxAB47cmPijiDEeTBMPfhAnCc3O7wlB-8iGkucJWHnfMwj-pHA4YDRRCRgO6Kd64ixEa7wefZEwxDwxfG9zi4_n_88-5pffP_y7ez0IldC0pjLQgvsqhJYrbadkBxKzmohtSolNltJC6CpaypkXQFtdNM1CrbASlYAdg3n6-zDUje1dz1hiO1ogsJhAItuCm1dFbIpWD3LN3_JvZu8Tc3NiDeNoEVCbxfUw4CtsdpFD2ou2Z4yUVayFuki19nmHyo9HY5GOYvapPEHC97_sWCHMMRdcMMUjbPhIfy4QOVdCB51e_BmBH_bFrSdw29T-O0cfpvCT_zV8UzTdsTuDv9OO4F3RwBBwaA9WGXCvStpRVlFk8sXF9KU7dHfX85_NiaLtxAnj3cFE5rNQl4vRINrofdp28sfaVKkn1LyQgr-C3mC1zs</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Akhavan, T</creator><creator>Luhovyy, B.L</creator><creator>Anderson, G.H</creator><general>Nature Publishing Group</general><general>Nature Publishing Group UK</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20110401</creationdate><title>Effect of drinking compared with eating sugars or whey protein on short-term appetite and food intake</title><author>Akhavan, T ; Luhovyy, B.L ; Anderson, G.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-71f5ed64a28cbd573a432857fc47e9b701a058205786a09f9d9caba2421aed933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>631/443/319/1488</topic><topic>Adult</topic><topic>Appetite</topic><topic>Appetite Regulation</topic><topic>Beverages</topic><topic>Biological and medical sciences</topic><topic>Calories</topic><topic>cross-over studies</topic><topic>Design</topic><topic>Diet</topic><topic>Dietary Carbohydrates - administration & dosage</topic><topic>drinking</topic><topic>Drinking - physiology</topic><topic>Eating - physiology</topic><topic>Energy</topic><topic>Energy Intake</topic><topic>Epidemiology</topic><topic>Experiments</topic><topic>Food</topic><topic>Food habits</topic><topic>food intake</topic><topic>foods</topic><topic>fructose</topic><topic>Fruit juices</topic><topic>gelatin</topic><topic>Health aspects</topic><topic>Health Promotion and Disease Prevention</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Males</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>men</topic><topic>Metabolic Diseases</topic><topic>Milk Proteins - administration & dosage</topic><topic>Obesity</topic><topic>original-article</topic><topic>Proteins</topic><topic>Public Health</topic><topic>Satiation - physiology</topic><topic>satiety</topic><topic>sucrose</topic><topic>Sugar</topic><topic>whey protein</topic><topic>Whey Proteins</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akhavan, T</creatorcontrib><creatorcontrib>Luhovyy, B.L</creatorcontrib><creatorcontrib>Anderson, G.H</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akhavan, T</au><au>Luhovyy, B.L</au><au>Anderson, G.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of drinking compared with eating sugars or whey protein on short-term appetite and food intake</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>35</volume><issue>4</issue><spage>562</spage><epage>569</epage><pages>562-569</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>Background: It is hypothesized that a solid form of food or food components suppresses subjective appetite and short-term food intake (FI) more than a liquid form. Objective: To compare the effect of eating solid vs drinking liquid forms of gelatin, sucrose and its component mixtures, and whey protein, on subjective appetite and FI in young men. Design and subjects: A randomized crossover design was used in three experiments in which the subjects were healthy males of normal weight. Solid and liquid forms of gelatin (6g) (experiment 1, n=14), sucrose (75g) and a mixture of 50% glucose/50% fructose (G50:F50) (experiment 2, n=15), and acid and sweet whey protein (50g) (experiment 3, n=14) were compared. The controls were water (experiments 1 and 3) and calorie-free sweetened water with gelatin (sweet gelatin, experiment 1) or calorie-free sweetened water (sweet control, experiment 2). Subjective average appetite was measured by visual analog scales over 1h and ad libitum FI was measured 1h after treatment consumption. Results: Average appetite area under the curve was not different between solid and liquid forms of sugars, but was larger, indicating greater satiety for solid compared with liquid forms of gelatin and sweet, but not acid whey protein. The FI was not different from that of control because of solid or liquid sugars or gelatin treatments. However, both solid and liquid forms of whey protein, with no difference among them, suppressed FI compared with control (P<0.05). Conclusion: Macronutrient composition is more important than physical state of foods in determining subjective appetite and FI.</abstract><cop>London</cop><pub>Nature Publishing Group</pub><pmid>20733582</pmid><doi>10.1038/ijo.2010.163</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0307-0565 |
ispartof | International Journal of Obesity, 2011-04, Vol.35 (4), p.562-569 |
issn | 0307-0565 1476-5497 |
language | eng |
recordid | cdi_proquest_miscellaneous_861791283 |
source | MEDLINE; Nature Journals Online; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
subjects | 631/443/319/1488 Adult Appetite Appetite Regulation Beverages Biological and medical sciences Calories cross-over studies Design Diet Dietary Carbohydrates - administration & dosage drinking Drinking - physiology Eating - physiology Energy Energy Intake Epidemiology Experiments Food Food habits food intake foods fructose Fruit juices gelatin Health aspects Health Promotion and Disease Prevention Humans Hypotheses Internal Medicine Male Males Medical research Medical sciences Medicine Medicine & Public Health men Metabolic Diseases Milk Proteins - administration & dosage Obesity original-article Proteins Public Health Satiation - physiology satiety sucrose Sugar whey protein Whey Proteins Young Adult |
title | Effect of drinking compared with eating sugars or whey protein on short-term appetite and food intake |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T02%3A52%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20drinking%20compared%20with%20eating%20sugars%20or%20whey%20protein%20on%20short-term%20appetite%20and%20food%20intake&rft.jtitle=International%20Journal%20of%20Obesity&rft.au=Akhavan,%20T&rft.date=2011-04-01&rft.volume=35&rft.issue=4&rft.spage=562&rft.epage=569&rft.pages=562-569&rft.issn=0307-0565&rft.eissn=1476-5497&rft.coden=IJOBDP&rft_id=info:doi/10.1038/ijo.2010.163&rft_dat=%3Cgale_proqu%3EA254678507%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=861399501&rft_id=info:pmid/20733582&rft_galeid=A254678507&rfr_iscdi=true |