Prostaglandin E2 vaginal gel or tablets for the induction of labour at term: a randomised controlled trial
Please cite this paper as: Taher S, Inder J, Soltan S, Eliahoo J, Edmonds D, Bennett P. Prostaglandin E2 vaginal gel or tablets for the induction of labour at term: a randomised controlled trial. BJOG 2011;118:719–725. Objective To compare the effectiveness of prostaglandin E2 (dinopristone) vagina...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 2011-05, Vol.118 (6), p.719-725 |
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| creator | Taher, SE Inder, JW Soltan, SA Eliahoo, J Edmonds, DK Bennett, PR |
| description | Please cite this paper as: Taher S, Inder J, Soltan S, Eliahoo J, Edmonds D, Bennett P. Prostaglandin E2 vaginal gel or tablets for the induction of labour at term: a randomised controlled trial. BJOG 2011;118:719–725.
Objective To compare the effectiveness of prostaglandin E2 (dinopristone) vaginal gel versus vaginal tablets for the induction of labour at term.
Design Randomised controlled clinical trial.
Setting University maternity hospital in London.
Population Pregnant women with cephalic presentation undergoing induction of labour after 37 weeks of gestation.
Methods Prostaglandin E2 vaginal tablets (3 mg) or vaginal gel (1 mg/2 mg) was administered at 6‐hourly intervals until the cervix was suitable for amniotomy.
Main outcome measures Induction to delivery interval, in minutes; rate of failed induction of labour requiring caesarean delivery.
Results Eighty‐two women received prostaglandin gel; 83 women received vaginal tablets. There were significant differences between the two treatment groups in the primary outcomes. The mean induction to delivery interval was significantly shorter in women who received the gel (1400 minutes, 690–2280 minutes, versus 1780 minutes, 960–2640 minutes; P = 0.03). The rate of failed induction of labour was significantly higher in women who received tablets (10.84 versus 1.22%; P = 0.01). Subanalysis showed that these differences were only representative of differences in the groups of primigravid women. There were no significant differences in any of the secondary outcomes, including the number of women who required syntocinon augmentation, the rate of uterine hyperstimulation, the need for epidural analgesia, meconium staining of liquor, the need for fetal blood sampling, or delivery by caesarean section. There were no differences in adverse maternal and neonatal outcomes.
Conclusion Prostaglandin E2 vaginal gel is superior to vaginal tablets for the induction of labour. |
| doi_str_mv | 10.1111/j.1471-0528.2011.02901.x |
| format | Article |
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Objective To compare the effectiveness of prostaglandin E2 (dinopristone) vaginal gel versus vaginal tablets for the induction of labour at term.
Design Randomised controlled clinical trial.
Setting University maternity hospital in London.
Population Pregnant women with cephalic presentation undergoing induction of labour after 37 weeks of gestation.
Methods Prostaglandin E2 vaginal tablets (3 mg) or vaginal gel (1 mg/2 mg) was administered at 6‐hourly intervals until the cervix was suitable for amniotomy.
Main outcome measures Induction to delivery interval, in minutes; rate of failed induction of labour requiring caesarean delivery.
Results Eighty‐two women received prostaglandin gel; 83 women received vaginal tablets. There were significant differences between the two treatment groups in the primary outcomes. The mean induction to delivery interval was significantly shorter in women who received the gel (1400 minutes, 690–2280 minutes, versus 1780 minutes, 960–2640 minutes; P = 0.03). The rate of failed induction of labour was significantly higher in women who received tablets (10.84 versus 1.22%; P = 0.01). Subanalysis showed that these differences were only representative of differences in the groups of primigravid women. There were no significant differences in any of the secondary outcomes, including the number of women who required syntocinon augmentation, the rate of uterine hyperstimulation, the need for epidural analgesia, meconium staining of liquor, the need for fetal blood sampling, or delivery by caesarean section. There were no differences in adverse maternal and neonatal outcomes.
Conclusion Prostaglandin E2 vaginal gel is superior to vaginal tablets for the induction of labour.</description><identifier>ISSN: 1470-0328</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/j.1471-0528.2011.02901.x</identifier><identifier>PMID: 21429067</identifier><identifier>CODEN: BIOGFQ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Administration, Intravaginal ; Adult ; Biological and medical sciences ; Cesarean Section - statistics & numerical data ; Clinical trials ; Comparative studies ; Dinoprostone ; Drug therapy ; Female ; Gel ; Gynecology. Andrology. Obstetrics ; Humans ; Induced labor ; induction ; Labor, Induced - methods ; labour ; Medical sciences ; Obstetric Labor Complications - etiology ; Oxytocics ; Parity ; Pregnancy ; Pregnancy Outcome ; prostaglandin ; tablet ; Tablets ; Term Birth ; Vaginal Creams, Foams, and Jellies</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 2011-05, Vol.118 (6), p.719-725</ispartof><rights>2011 Imperial College London BJOG An International Journal of Obstetrics and Gynaecology © 2011 RCOG</rights><rights>2015 INIST-CNRS</rights><rights>2011 Imperial College London BJOG An International Journal of Obstetrics and Gynaecology © 2011 RCOG.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3761-1e3345a8701cf8b70b106970516a096170f844a37bd9231164918fb81a9a0a553</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-0528.2011.02901.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-0528.2011.02901.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24073932$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21429067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taher, SE</creatorcontrib><creatorcontrib>Inder, JW</creatorcontrib><creatorcontrib>Soltan, SA</creatorcontrib><creatorcontrib>Eliahoo, J</creatorcontrib><creatorcontrib>Edmonds, DK</creatorcontrib><creatorcontrib>Bennett, PR</creatorcontrib><title>Prostaglandin E2 vaginal gel or tablets for the induction of labour at term: a randomised controlled trial</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>BJOG</addtitle><description>Please cite this paper as: Taher S, Inder J, Soltan S, Eliahoo J, Edmonds D, Bennett P. Prostaglandin E2 vaginal gel or tablets for the induction of labour at term: a randomised controlled trial. BJOG 2011;118:719–725.
Objective To compare the effectiveness of prostaglandin E2 (dinopristone) vaginal gel versus vaginal tablets for the induction of labour at term.
Design Randomised controlled clinical trial.
Setting University maternity hospital in London.
Population Pregnant women with cephalic presentation undergoing induction of labour after 37 weeks of gestation.
Methods Prostaglandin E2 vaginal tablets (3 mg) or vaginal gel (1 mg/2 mg) was administered at 6‐hourly intervals until the cervix was suitable for amniotomy.
Main outcome measures Induction to delivery interval, in minutes; rate of failed induction of labour requiring caesarean delivery.
Results Eighty‐two women received prostaglandin gel; 83 women received vaginal tablets. There were significant differences between the two treatment groups in the primary outcomes. The mean induction to delivery interval was significantly shorter in women who received the gel (1400 minutes, 690–2280 minutes, versus 1780 minutes, 960–2640 minutes; P = 0.03). The rate of failed induction of labour was significantly higher in women who received tablets (10.84 versus 1.22%; P = 0.01). Subanalysis showed that these differences were only representative of differences in the groups of primigravid women. There were no significant differences in any of the secondary outcomes, including the number of women who required syntocinon augmentation, the rate of uterine hyperstimulation, the need for epidural analgesia, meconium staining of liquor, the need for fetal blood sampling, or delivery by caesarean section. There were no differences in adverse maternal and neonatal outcomes.
Conclusion Prostaglandin E2 vaginal gel is superior to vaginal tablets for the induction of labour.</description><subject>Administration, Intravaginal</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cesarean Section - statistics & numerical data</subject><subject>Clinical trials</subject><subject>Comparative studies</subject><subject>Dinoprostone</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Gel</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Induced labor</subject><subject>induction</subject><subject>Labor, Induced - methods</subject><subject>labour</subject><subject>Medical sciences</subject><subject>Obstetric Labor Complications - etiology</subject><subject>Oxytocics</subject><subject>Parity</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>prostaglandin</subject><subject>tablet</subject><subject>Tablets</subject><subject>Term Birth</subject><subject>Vaginal Creams, Foams, and Jellies</subject><issn>1470-0328</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1u1TAQhS0EoqXwCshCQqwSZuwkTpBYQFX-VKksYG1NEufiyDcutgPt2-PcXoqENz7SfD7ymcMYRygxn9dziZXCAmrRlgIQSxAdYHnzgJ3eDx4eNBQgRXvCnsQ4A2AjQD5mJwKr_KBRp2z-GnxMtHO0jHbhF4L_op1dyPGdcdwHnqh3JkU-bfqH4XYZ1yFZv3A_cUe9XwOnxJMJ-zeceMg-fm-jGfnglxS8c1mmYMk9ZY8mctE8O95n7PuHi2_nn4rLq4-fz99dFoNUDRZopKxqahXgMLW9gh6h6RTU2BB0DSqY2qoiqfqxExKxqTpsp75F6gioruUZe3Xnex38z9XEpPN_BuNyROPXqNvs0WUnlckX_5FzjpPDHyAhG6k2u-dHaO33ZtTXwe4p3Oq_O8zAyyNAcSA35RUMNv7jKlCykyJzb--439aZ2_s5gt461bPeqtNbdXrrVB861Tf6_ZerTck_qxWRzw</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>Taher, SE</creator><creator>Inder, JW</creator><creator>Soltan, SA</creator><creator>Eliahoo, J</creator><creator>Edmonds, DK</creator><creator>Bennett, PR</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201105</creationdate><title>Prostaglandin E2 vaginal gel or tablets for the induction of labour at term: a randomised controlled trial</title><author>Taher, SE ; Inder, JW ; Soltan, SA ; Eliahoo, J ; Edmonds, DK ; Bennett, PR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3761-1e3345a8701cf8b70b106970516a096170f844a37bd9231164918fb81a9a0a553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Administration, Intravaginal</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cesarean Section - statistics & numerical data</topic><topic>Clinical trials</topic><topic>Comparative studies</topic><topic>Dinoprostone</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Gel</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Induced labor</topic><topic>induction</topic><topic>Labor, Induced - methods</topic><topic>labour</topic><topic>Medical sciences</topic><topic>Obstetric Labor Complications - etiology</topic><topic>Oxytocics</topic><topic>Parity</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>prostaglandin</topic><topic>tablet</topic><topic>Tablets</topic><topic>Term Birth</topic><topic>Vaginal Creams, Foams, and Jellies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taher, SE</creatorcontrib><creatorcontrib>Inder, JW</creatorcontrib><creatorcontrib>Soltan, SA</creatorcontrib><creatorcontrib>Eliahoo, J</creatorcontrib><creatorcontrib>Edmonds, DK</creatorcontrib><creatorcontrib>Bennett, PR</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taher, SE</au><au>Inder, JW</au><au>Soltan, SA</au><au>Eliahoo, J</au><au>Edmonds, DK</au><au>Bennett, PR</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prostaglandin E2 vaginal gel or tablets for the induction of labour at term: a randomised controlled trial</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>BJOG</addtitle><date>2011-05</date><risdate>2011</risdate><volume>118</volume><issue>6</issue><spage>719</spage><epage>725</epage><pages>719-725</pages><issn>1470-0328</issn><eissn>1471-0528</eissn><coden>BIOGFQ</coden><abstract>Please cite this paper as: Taher S, Inder J, Soltan S, Eliahoo J, Edmonds D, Bennett P. Prostaglandin E2 vaginal gel or tablets for the induction of labour at term: a randomised controlled trial. BJOG 2011;118:719–725.
Objective To compare the effectiveness of prostaglandin E2 (dinopristone) vaginal gel versus vaginal tablets for the induction of labour at term.
Design Randomised controlled clinical trial.
Setting University maternity hospital in London.
Population Pregnant women with cephalic presentation undergoing induction of labour after 37 weeks of gestation.
Methods Prostaglandin E2 vaginal tablets (3 mg) or vaginal gel (1 mg/2 mg) was administered at 6‐hourly intervals until the cervix was suitable for amniotomy.
Main outcome measures Induction to delivery interval, in minutes; rate of failed induction of labour requiring caesarean delivery.
Results Eighty‐two women received prostaglandin gel; 83 women received vaginal tablets. There were significant differences between the two treatment groups in the primary outcomes. The mean induction to delivery interval was significantly shorter in women who received the gel (1400 minutes, 690–2280 minutes, versus 1780 minutes, 960–2640 minutes; P = 0.03). The rate of failed induction of labour was significantly higher in women who received tablets (10.84 versus 1.22%; P = 0.01). Subanalysis showed that these differences were only representative of differences in the groups of primigravid women. There were no significant differences in any of the secondary outcomes, including the number of women who required syntocinon augmentation, the rate of uterine hyperstimulation, the need for epidural analgesia, meconium staining of liquor, the need for fetal blood sampling, or delivery by caesarean section. There were no differences in adverse maternal and neonatal outcomes.
Conclusion Prostaglandin E2 vaginal gel is superior to vaginal tablets for the induction of labour.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21429067</pmid><doi>10.1111/j.1471-0528.2011.02901.x</doi><tpages>7</tpages></addata></record> |
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| ispartof | BJOG : an international journal of obstetrics and gynaecology, 2011-05, Vol.118 (6), p.719-725 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Administration, Intravaginal Adult Biological and medical sciences Cesarean Section - statistics & numerical data Clinical trials Comparative studies Dinoprostone Drug therapy Female Gel Gynecology. Andrology. Obstetrics Humans Induced labor induction Labor, Induced - methods labour Medical sciences Obstetric Labor Complications - etiology Oxytocics Parity Pregnancy Pregnancy Outcome prostaglandin tablet Tablets Term Birth Vaginal Creams, Foams, and Jellies |
| title | Prostaglandin E2 vaginal gel or tablets for the induction of labour at term: a randomised controlled trial |
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