Characteristic effects of methylglyoxal and its degraded product formate on viability of human histiocytes: A possible detoxification pathway of methylglyoxal

► Methylglyoxal is degraded to formic acid by oxidation. ► With endogenous hydrogen peroxide, methylglyoxal exerted oxidative cytotoxicity. ► Whereas, formic acid increased cell viability. ► Formic acid may counteract the methylglyoxal toxicity. Methylglyoxal (MGO) is a toxic and highly reactive alp...

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Veröffentlicht in:	Biochemical and biophysical research communications 2011-04, Vol.407 (2), p.426-431
Hauptverfasser:	Koizumi, Kenji, Nakayama, Masaaki, Zhu, Wan-Jun, Ito, Sadayoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell Count Cell Line Cell Survival - drug effects Formates - pharmacokinetics Formates - toxicity Formic acid Glutathione - metabolism Histiocytes - drug effects Histiocytes - physiology Humans Inactivation, Metabolic Methylglyoxal Oxidative stress Purine metabolism Pyruvaldehyde - pharmacokinetics Pyruvaldehyde - toxicity Viability
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