Respiratory competent mitochondria in human ovarian and peritoneal cancer

Impaired respiration was proposed by Warburg to be responsible for aerobic glycolysis in cancer cells. However, intact mitochondria isolated from human ovarian and peritoneal cancer tissues exhibit substantive oxidative phosphorylating activities in terms of membrane potential, ATP biosynthesis and...

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Veröffentlicht in:	Mitochondrion 2011-05, Vol.11 (3), p.437-443
Hauptverfasser:	Lim, Hwee Ying, Ho, Qin Shi, Low, Jeffrey, Choolani, Mahesh, Wong, Kim Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - physiopathology Adenosine Triphosphate - metabolism Adult Aged Animals Cell Respiration Female Glutamate Dehydrogenase - metabolism Humans Malate Dehydrogenase - metabolism Male Membrane Potential, Mitochondrial Mice Middle Aged Mitochondria - metabolism Mitochondria - physiology Ovarian Neoplasms - physiopathology Oxidative Phosphorylation Oxygen - metabolism Peritoneal Neoplasms - physiopathology Succinate Dehydrogenase - metabolism
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