No association of PTPN22 gene polymorphism with rheumatoid arthritis in Turkey
Although the association of rheumatoid arthritis (RA) with HLA-DRB1 (shared epitope) is well demonstrated in many ethnic populations, the role of other RA-associated risk loci is not clarified. In this study, the functional single nucleotide polymorphism (SNP) of PTPN22 gene was investigated in Turk...
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| Veröffentlicht in: | Rheumatology international 2009-11, Vol.30 (1), p.81-83 |
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| creator | Sahin, N. Gunduz, F. Inanc, N. Direskeneli, Haner Saruhan-Direskeneli, G. |
| description | Although the association of rheumatoid arthritis (RA) with HLA-DRB1 (shared epitope) is well demonstrated in many ethnic populations, the role of other RA-associated risk loci is not clarified. In this study, the functional single nucleotide polymorphism (SNP) of
PTPN22
gene was investigated in Turkey. 167 patients with RA and 177 healthy controls are genotyped by polymerase chain reaction (PCR)-RFLP for the SNP (rs2476601, A/G) of
PTPN22
gene. Polymorphic region was amplified by PCR and digested with
Xcm
I enzyme. Heterozygous genotype (AG) was present in 5.1% (9/177) of the controls and in 6.6% (11/167) of RA group (
p
= 0.55, OR 1.3, 95% CI 0.53–3.26). There was also no association between any clinical feature, RF positivity and presence of this SNP. In conclusion, the distribution of
PTPN22
polymorphism did not reveal any association with RA in Turkey. |
| doi_str_mv | 10.1007/s00296-009-0919-2 |
| format | Article |
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PTPN22
gene was investigated in Turkey. 167 patients with RA and 177 healthy controls are genotyped by polymerase chain reaction (PCR)-RFLP for the SNP (rs2476601, A/G) of
PTPN22
gene. Polymorphic region was amplified by PCR and digested with
Xcm
I enzyme. Heterozygous genotype (AG) was present in 5.1% (9/177) of the controls and in 6.6% (11/167) of RA group (
p
= 0.55, OR 1.3, 95% CI 0.53–3.26). There was also no association between any clinical feature, RF positivity and presence of this SNP. In conclusion, the distribution of
PTPN22
polymorphism did not reveal any association with RA in Turkey.</description><identifier>ISSN: 0172-8172</identifier><identifier>EISSN: 1437-160X</identifier><identifier>DOI: 10.1007/s00296-009-0919-2</identifier><identifier>PMID: 19357851</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Arthritis, Rheumatoid - enzymology ; Arthritis, Rheumatoid - ethnology ; Arthritis, Rheumatoid - genetics ; Asian Continental Ancestry Group - genetics ; Case-Control Studies ; Chi-Square Distribution ; Female ; Gene Frequency ; Genes ; Genetic Predisposition to Disease ; Heterozygote ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Odds Ratio ; Original Article ; Phenotype ; Polymerase Chain Reaction ; Polymorphism, Single Nucleotide ; Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics ; Rheumatoid arthritis ; Rheumatology ; Risk Assessment ; Risk Factors ; Turkey - epidemiology</subject><ispartof>Rheumatology international, 2009-11, Vol.30 (1), p.81-83</ispartof><rights>Springer-Verlag 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-c853a6ec4985aafe039568336d4e16c73188f50d57a6d3aab6f303bc51dcfff13</citedby><cites>FETCH-LOGICAL-c403t-c853a6ec4985aafe039568336d4e16c73188f50d57a6d3aab6f303bc51dcfff13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00296-009-0919-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00296-009-0919-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19357851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sahin, N.</creatorcontrib><creatorcontrib>Gunduz, F.</creatorcontrib><creatorcontrib>Inanc, N.</creatorcontrib><creatorcontrib>Direskeneli, Haner</creatorcontrib><creatorcontrib>Saruhan-Direskeneli, G.</creatorcontrib><title>No association of PTPN22 gene polymorphism with rheumatoid arthritis in Turkey</title><title>Rheumatology international</title><addtitle>Rheumatol Int</addtitle><addtitle>Rheumatol Int</addtitle><description>Although the association of rheumatoid arthritis (RA) with HLA-DRB1 (shared epitope) is well demonstrated in many ethnic populations, the role of other RA-associated risk loci is not clarified. In this study, the functional single nucleotide polymorphism (SNP) of
PTPN22
gene was investigated in Turkey. 167 patients with RA and 177 healthy controls are genotyped by polymerase chain reaction (PCR)-RFLP for the SNP (rs2476601, A/G) of
PTPN22
gene. Polymorphic region was amplified by PCR and digested with
Xcm
I enzyme. Heterozygous genotype (AG) was present in 5.1% (9/177) of the controls and in 6.6% (11/167) of RA group (
p
= 0.55, OR 1.3, 95% CI 0.53–3.26). There was also no association between any clinical feature, RF positivity and presence of this SNP. In conclusion, the distribution of
PTPN22
polymorphism did not reveal any association with RA in Turkey.</description><subject>Adult</subject><subject>Arthritis, Rheumatoid - enzymology</subject><subject>Arthritis, Rheumatoid - ethnology</subject><subject>Arthritis, Rheumatoid - genetics</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Heterozygote</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Original Article</subject><subject>Phenotype</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatology</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Turkey - epidemiology</subject><issn>0172-8172</issn><issn>1437-160X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1rGzEQhkVpaJy0P6CXInppLtvMSCutdCyhXxCcHBzoTchaKVbqXbnSLsX_vjI2BArtRYPQM-9oeAh5i_ARAbrrAsC0bAB0Axp1w16QBba8a1DCj5dkAdixRtXjnFyU8gT1LiW8IueoueiUwAVZLhO1pSQX7RTTSFOg96v7JWP00Y-e7tJ2P6S828Qy0N9x2tC88fNgpxR7avO0yXGKhcaRrub80-9fk7Ngt8W_OdVL8vDl8-rmW3N79_X7zafbxrXAp8Ypwa30rtVKWBs8cC2k4lz2rUfpOo5KBQG96KzsubVrGTjwtRPYuxAC8kvy4Zi7y-nX7Mtkhlic327t6NNcjJIo6o6KVfLqvyR2grey1UxW9P1f6FOa81j3MEq1yHSnVIXwCLmcSsk-mF2Og817g2AOVszRiqlWzMGKOfzh3Sl4Xg--f-44aagAOwKlPo2PPj9P_nfqH2GjlqE</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Sahin, N.</creator><creator>Gunduz, F.</creator><creator>Inanc, N.</creator><creator>Direskeneli, Haner</creator><creator>Saruhan-Direskeneli, G.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>No association of PTPN22 gene polymorphism with rheumatoid arthritis in Turkey</title><author>Sahin, N. ; Gunduz, F. ; Inanc, N. ; Direskeneli, Haner ; Saruhan-Direskeneli, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-c853a6ec4985aafe039568336d4e16c73188f50d57a6d3aab6f303bc51dcfff13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Arthritis, Rheumatoid - enzymology</topic><topic>Arthritis, Rheumatoid - ethnology</topic><topic>Arthritis, Rheumatoid - genetics</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Case-Control Studies</topic><topic>Chi-Square Distribution</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease</topic><topic>Heterozygote</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Original Article</topic><topic>Phenotype</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatology</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Turkey - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sahin, N.</creatorcontrib><creatorcontrib>Gunduz, F.</creatorcontrib><creatorcontrib>Inanc, N.</creatorcontrib><creatorcontrib>Direskeneli, Haner</creatorcontrib><creatorcontrib>Saruhan-Direskeneli, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sahin, N.</au><au>Gunduz, F.</au><au>Inanc, N.</au><au>Direskeneli, Haner</au><au>Saruhan-Direskeneli, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No association of PTPN22 gene polymorphism with rheumatoid arthritis in Turkey</atitle><jtitle>Rheumatology international</jtitle><stitle>Rheumatol Int</stitle><addtitle>Rheumatol Int</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>30</volume><issue>1</issue><spage>81</spage><epage>83</epage><pages>81-83</pages><issn>0172-8172</issn><eissn>1437-160X</eissn><abstract>Although the association of rheumatoid arthritis (RA) with HLA-DRB1 (shared epitope) is well demonstrated in many ethnic populations, the role of other RA-associated risk loci is not clarified. In this study, the functional single nucleotide polymorphism (SNP) of
PTPN22
gene was investigated in Turkey. 167 patients with RA and 177 healthy controls are genotyped by polymerase chain reaction (PCR)-RFLP for the SNP (rs2476601, A/G) of
PTPN22
gene. Polymorphic region was amplified by PCR and digested with
Xcm
I enzyme. Heterozygous genotype (AG) was present in 5.1% (9/177) of the controls and in 6.6% (11/167) of RA group (
p
= 0.55, OR 1.3, 95% CI 0.53–3.26). There was also no association between any clinical feature, RF positivity and presence of this SNP. In conclusion, the distribution of
PTPN22
polymorphism did not reveal any association with RA in Turkey.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19357851</pmid><doi>10.1007/s00296-009-0919-2</doi><tpages>3</tpages></addata></record> |
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| subjects | Adult Arthritis, Rheumatoid - enzymology Arthritis, Rheumatoid - ethnology Arthritis, Rheumatoid - genetics Asian Continental Ancestry Group - genetics Case-Control Studies Chi-Square Distribution Female Gene Frequency Genes Genetic Predisposition to Disease Heterozygote Humans Male Medicine Medicine & Public Health Middle Aged Odds Ratio Original Article Phenotype Polymerase Chain Reaction Polymorphism, Single Nucleotide Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics Rheumatoid arthritis Rheumatology Risk Assessment Risk Factors Turkey - epidemiology |
| title | No association of PTPN22 gene polymorphism with rheumatoid arthritis in Turkey |
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