A polymorphism in the 3'-utr of cyclooxygenase-2 and the risk of gastric cancer

A polymorphism in the 3'-utr of cyclooxygenase-2 and the risk of gastric cancer

A polymorphism within the 3'-UTR 8473T↷C of the cyclooxygenase-2 (COX-2) gene, which plays a role in gastrointestinal cancer development, has been associated with susceptibility to malignant disease. Here, we report on the interaction between the COX-2 3'-UTR T↷C polymorphism and gastric c...

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Veröffentlicht in:Molecular medicine reports 2008-07, Vol.1 (4), p.561-564
Hauptverfasser: Shibata, Tomoyuki, Arisawa, Tomiyasu, Tahara, Tomomitsu, Hirata, Ichiro, Nakano, Hiroshi
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container_issue 4
container_start_page 561
container_title Molecular medicine reports
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creator Shibata, Tomoyuki
Arisawa, Tomiyasu
Tahara, Tomomitsu
Hirata, Ichiro
Nakano, Hiroshi
description A polymorphism within the 3'-UTR 8473T↷C of the cyclooxygenase-2 (COX-2) gene, which plays a role in gastrointestinal cancer development, has been associated with susceptibility to malignant disease. Here, we report on the interaction between the COX-2 3'-UTR T↷C polymorphism and gastric cancer development. DNA from 121 Japanese patients with gastric cancer and 126 age-matched control patients was examined for the COX-2 polymorphism by PCR-RFLP. Odds ratios and the 95% confidence interval (CI) were calculated. Homozygous carriage of the COX-2 8473C allele tended to be associated with an increased risk of gastric cancer compared to the T allele homozygotes of the subjects (OR=3.70; 95% CI, 0.96-14.25). The CC allele was associated with a significant increased risk of diffuse-type gastric cancer (OR=5.29; 95% CI, 1.18-23.70). These findings suggest that the COX-2 3'-UTR 8473T↷C polymorphism could be used as a marker for genetic susceptibility to gastric cancer in Japanese populations.
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title A polymorphism in the 3'-utr of cyclooxygenase-2 and the risk of gastric cancer
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