p85alpha regulates osteoblast differentiation by cross-talking with the MAPK pathway

Class IA phosphoinositide 3-kinase (PI3K) is involved in regulating many cellular functions including cell growth, proliferation, cell survival, and differentiation. The p85 regulatory subunit is a critical component of the PI3K signaling pathway. Mesenchymal stem cells (MSC) are multipotent cells t...

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Veröffentlicht in:	The Journal of biological chemistry 2011-04, Vol.286 (15), p.13512-13521
Hauptverfasser:	Wu, Xiaohua, Chen, Shi, Orlando, Selina A, Yuan, Jin, Kim, Edward T, Munugalavadla, Veerendra, Mali, Raghuveer S, Kapur, Reuben, Yang, Feng-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - genetics Alkaline Phosphatase - metabolism Animals Cell Differentiation - physiology Chromones - pharmacology Class Ia Phosphatidylinositol 3-Kinase - genetics Class Ia Phosphatidylinositol 3-Kinase - metabolism Cyclin D - genetics Cyclin D - metabolism Cyclin E - genetics Cyclin E - metabolism Enzyme Inhibitors - pharmacology Flavonoids - pharmacology MAP Kinase Signaling System - physiology Mice Mice, Knockout Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism Morpholines - pharmacology Osteoblasts - cytology Osteoblasts - enzymology Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism
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