Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population
Atrial fibrillation (AF) is the most common arrhythmia in the clinical setting and an independent risk factor for stroke. Approximately 10 million Chinese people are affected by AF, but the genetic basis is largely unknown. A recent genome-wide association study in Iceland identified association bet...
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| Veröffentlicht in: | Human genetics 2009-12, Vol.126 (6), p.843-849 |
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| creator | Shi, Lisong Li, Cong Wang, Chuchu Xia, Yunlong Wu, Gang Wang, Fan Xu, Chengqi Wang, Pengyun Li, Xiuchun Wang, Dan Xiong, Xin Bai, Ying Liu, Mugen Liu, Jingyu Ren, Xiang Gao, Lianjun Wang, Binbin Zeng, Qiutang Yang, Bo Ma, Xu Yang, Yanzong Tu, Xin Wang, Qing Kenneth |
| description | Atrial fibrillation (AF) is the most common arrhythmia in the clinical setting and an independent risk factor for stroke. Approximately 10 million Chinese people are affected by AF, but the genetic basis is largely unknown. A recent genome-wide association study in Iceland identified association between SNP rs2200733 on 4q25 and AF; however, many independent replication studies are essential to unequivocally validate this association. To assess the association between rs2200733 and AF as well as that between rs2200733 and ischemic stroke in a mainland Chinese Han population, we carried out case-control association studies with 383 AF patients versus 851 non-AF controls and 811 ischemic stroke patients versus 688 non-stroke controls. Highly significant association was detected between rs2200733 and AF in a Chinese Han population (allelic P = 3.7 × 10⁻¹¹ with OR = 1.81; genotypic P = 4.1 × 10⁻¹² with a dominant model). When the AF cases were divided into lone AF (32.6%) and other types of AF (67.4%), significantly stronger association was found with lone AF (OR = 2.40, P = 1.3 × 10⁻⁹ compared to OR = 1.59, P = 6.2 × 10⁻⁷ for other types of AF; P = 0.02 for two ORs). No significant association was found between rs2200733 and ischemic stroke. Our results suggest that SNP rs2200733 confers a highly significant risk of AF, but not ischemic stroke, in a more representative Chinese Han population in the mainland China. |
| doi_str_mv | 10.1007/s00439-009-0737-3 |
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Approximately 10 million Chinese people are affected by AF, but the genetic basis is largely unknown. A recent genome-wide association study in Iceland identified association between SNP rs2200733 on 4q25 and AF; however, many independent replication studies are essential to unequivocally validate this association. To assess the association between rs2200733 and AF as well as that between rs2200733 and ischemic stroke in a mainland Chinese Han population, we carried out case-control association studies with 383 AF patients versus 851 non-AF controls and 811 ischemic stroke patients versus 688 non-stroke controls. Highly significant association was detected between rs2200733 and AF in a Chinese Han population (allelic P = 3.7 × 10⁻¹¹ with OR = 1.81; genotypic P = 4.1 × 10⁻¹² with a dominant model). When the AF cases were divided into lone AF (32.6%) and other types of AF (67.4%), significantly stronger association was found with lone AF (OR = 2.40, P = 1.3 × 10⁻⁹ compared to OR = 1.59, P = 6.2 × 10⁻⁷ for other types of AF; P = 0.02 for two ORs). No significant association was found between rs2200733 and ischemic stroke. Our results suggest that SNP rs2200733 confers a highly significant risk of AF, but not ischemic stroke, in a more representative Chinese Han population in the mainland China.</description><identifier>ISSN: 0340-6717</identifier><identifier>EISSN: 1432-1203</identifier><identifier>DOI: 10.1007/s00439-009-0737-3</identifier><identifier>PMID: 19707791</identifier><identifier>CODEN: HUGEDQ</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Asian Continental Ancestry Group - genetics ; Atrial fibrillation ; Atrial Fibrillation - genetics ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Brain Ischemia - genetics ; Cardiac arrhythmia ; Cardiac dysrhythmias ; Cardiology. Vascular system ; Chromosomes ; Chromosomes, Human, Pair 4 ; Classical genetics, quantitative genetics, hybrids ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Function ; Genetic aspects ; Genetic research ; Genetics of eukaryotes. Biological and molecular evolution ; Genomes ; Genomics ; Heart ; Hospitals ; Human ; Human Genetics ; Humans ; Ischemia ; Male ; Medical research ; Medical sciences ; Medicine, Experimental ; Metabolic Diseases ; Methods, theories and miscellaneous ; Middle Aged ; Molecular Medicine ; Original Investigation ; Polymorphism, Single Nucleotide ; Risk factors ; Stroke ; Stroke (Disease) ; Stroke - genetics ; Stroke patients</subject><ispartof>Human genetics, 2009-12, Vol.126 (6), p.843-849</ispartof><rights>Springer-Verlag 2009</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2009 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-38242ad42c87d289b90cf4125b5ae321a98310fc2cc342d6b89b4317050237473</citedby><cites>FETCH-LOGICAL-c517t-38242ad42c87d289b90cf4125b5ae321a98310fc2cc342d6b89b4317050237473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00439-009-0737-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00439-009-0737-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22167337$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19707791$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shi, Lisong</creatorcontrib><creatorcontrib>Li, Cong</creatorcontrib><creatorcontrib>Wang, Chuchu</creatorcontrib><creatorcontrib>Xia, Yunlong</creatorcontrib><creatorcontrib>Wu, Gang</creatorcontrib><creatorcontrib>Wang, Fan</creatorcontrib><creatorcontrib>Xu, Chengqi</creatorcontrib><creatorcontrib>Wang, Pengyun</creatorcontrib><creatorcontrib>Li, Xiuchun</creatorcontrib><creatorcontrib>Wang, Dan</creatorcontrib><creatorcontrib>Xiong, Xin</creatorcontrib><creatorcontrib>Bai, Ying</creatorcontrib><creatorcontrib>Liu, Mugen</creatorcontrib><creatorcontrib>Liu, Jingyu</creatorcontrib><creatorcontrib>Ren, Xiang</creatorcontrib><creatorcontrib>Gao, Lianjun</creatorcontrib><creatorcontrib>Wang, Binbin</creatorcontrib><creatorcontrib>Zeng, Qiutang</creatorcontrib><creatorcontrib>Yang, Bo</creatorcontrib><creatorcontrib>Ma, Xu</creatorcontrib><creatorcontrib>Yang, Yanzong</creatorcontrib><creatorcontrib>Tu, Xin</creatorcontrib><creatorcontrib>Wang, Qing Kenneth</creatorcontrib><title>Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population</title><title>Human genetics</title><addtitle>Hum Genet</addtitle><addtitle>Hum Genet</addtitle><description>Atrial fibrillation (AF) is the most common arrhythmia in the clinical setting and an independent risk factor for stroke. Approximately 10 million Chinese people are affected by AF, but the genetic basis is largely unknown. A recent genome-wide association study in Iceland identified association between SNP rs2200733 on 4q25 and AF; however, many independent replication studies are essential to unequivocally validate this association. To assess the association between rs2200733 and AF as well as that between rs2200733 and ischemic stroke in a mainland Chinese Han population, we carried out case-control association studies with 383 AF patients versus 851 non-AF controls and 811 ischemic stroke patients versus 688 non-stroke controls. Highly significant association was detected between rs2200733 and AF in a Chinese Han population (allelic P = 3.7 × 10⁻¹¹ with OR = 1.81; genotypic P = 4.1 × 10⁻¹² with a dominant model). When the AF cases were divided into lone AF (32.6%) and other types of AF (67.4%), significantly stronger association was found with lone AF (OR = 2.40, P = 1.3 × 10⁻⁹ compared to OR = 1.59, P = 6.2 × 10⁻⁷ for other types of AF; P = 0.02 for two ORs). No significant association was found between rs2200733 and ischemic stroke. Our results suggest that SNP rs2200733 confers a highly significant risk of AF, but not ischemic stroke, in a more representative Chinese Han population in the mainland China.</description><subject>Asian Continental Ancestry Group - genetics</subject><subject>Atrial fibrillation</subject><subject>Atrial Fibrillation - genetics</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain Ischemia - genetics</subject><subject>Cardiac arrhythmia</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiology. Vascular system</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, Pair 4</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Function</subject><subject>Genetic aspects</subject><subject>Genetic research</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Heart</subject><subject>Hospitals</subject><subject>Human</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Medicine, Experimental</subject><subject>Metabolic Diseases</subject><subject>Methods, theories and miscellaneous</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Original Investigation</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk factors</subject><subject>Stroke</subject><subject>Stroke (Disease)</subject><subject>Stroke - genetics</subject><subject>Stroke patients</subject><issn>0340-6717</issn><issn>1432-1203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kk1v1DAQhiMEokvhB3ABCwSIQ2D8FSfH1QpopUpIlJ4tr9fZdUnirScRcOWXM6usqMqhB8sa-5nvtyiec_jAAcxHBFCyKQHoGGlK-aBYcCVFyQXIh8UCpIKyMtycFE8QrwG4boR-XJzwxoAxDV8Uf5aIAbEPw8hSyxxi8tGNMQ0HM6MQlEhKRrbf5dQnTH1g6kZo9jOOO-bGHF3H2rjOsetmRzdsWES_C330DMecfgQW6ZmtdnEIGNiZG9g-7aeZf1o8al2H4dnxPi2uPn_6vjorL75-OV8tL0qvuRlLWQsl3EYJX5uNqJt1A75VXOi1dkEK7ppacmi98F4qsanWhCjJDWgQ0igjT4t3c9x9TjdTwNH2VGWgqoeQJrR1RePhvFJEvr2XFFwYUKYi8NV_4HWa8kBdEKMpsRKaoNcztHVdsHFo05idP0S0S9qB1rpqGqLe36F8Gsbwa9y6CdGeX367y_KZ9Tkh5tDafY69y78tB3tQhp2VYUkZ9qAMK8nnxbHUad2Hza3HUQoEvDkCDr3r2uwGH_EfJwSvSAiHMYqZQ_oatiHf9nxf9pezU-uSddtMga8uBXAJtKAKapB_AZcZ1So</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Shi, Lisong</creator><creator>Li, Cong</creator><creator>Wang, Chuchu</creator><creator>Xia, Yunlong</creator><creator>Wu, Gang</creator><creator>Wang, Fan</creator><creator>Xu, Chengqi</creator><creator>Wang, Pengyun</creator><creator>Li, Xiuchun</creator><creator>Wang, Dan</creator><creator>Xiong, Xin</creator><creator>Bai, Ying</creator><creator>Liu, Mugen</creator><creator>Liu, Jingyu</creator><creator>Ren, Xiang</creator><creator>Gao, Lianjun</creator><creator>Wang, Binbin</creator><creator>Zeng, Qiutang</creator><creator>Yang, Bo</creator><creator>Ma, Xu</creator><creator>Yang, Yanzong</creator><creator>Tu, Xin</creator><creator>Wang, Qing Kenneth</creator><general>Berlin/Heidelberg : Springer-Verlag</general><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20091201</creationdate><title>Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population</title><author>Shi, Lisong ; Li, Cong ; Wang, Chuchu ; Xia, Yunlong ; Wu, Gang ; Wang, Fan ; Xu, Chengqi ; Wang, Pengyun ; Li, Xiuchun ; Wang, Dan ; Xiong, Xin ; Bai, Ying ; Liu, Mugen ; Liu, Jingyu ; Ren, Xiang ; Gao, Lianjun ; Wang, Binbin ; Zeng, Qiutang ; Yang, Bo ; Ma, Xu ; Yang, Yanzong ; Tu, Xin ; Wang, Qing Kenneth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-38242ad42c87d289b90cf4125b5ae321a98310fc2cc342d6b89b4317050237473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Asian Continental Ancestry Group - genetics</topic><topic>Atrial fibrillation</topic><topic>Atrial Fibrillation - genetics</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain Ischemia - genetics</topic><topic>Cardiac arrhythmia</topic><topic>Cardiac dysrhythmias</topic><topic>Cardiology. Vascular system</topic><topic>Chromosomes</topic><topic>Chromosomes, Human, Pair 4</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Function</topic><topic>Genetic aspects</topic><topic>Genetic research</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Heart</topic><topic>Hospitals</topic><topic>Human</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Medicine, Experimental</topic><topic>Metabolic Diseases</topic><topic>Methods, theories and miscellaneous</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Original Investigation</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk factors</topic><topic>Stroke</topic><topic>Stroke (Disease)</topic><topic>Stroke - genetics</topic><topic>Stroke patients</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Lisong</creatorcontrib><creatorcontrib>Li, Cong</creatorcontrib><creatorcontrib>Wang, Chuchu</creatorcontrib><creatorcontrib>Xia, Yunlong</creatorcontrib><creatorcontrib>Wu, Gang</creatorcontrib><creatorcontrib>Wang, Fan</creatorcontrib><creatorcontrib>Xu, Chengqi</creatorcontrib><creatorcontrib>Wang, Pengyun</creatorcontrib><creatorcontrib>Li, Xiuchun</creatorcontrib><creatorcontrib>Wang, Dan</creatorcontrib><creatorcontrib>Xiong, Xin</creatorcontrib><creatorcontrib>Bai, Ying</creatorcontrib><creatorcontrib>Liu, Mugen</creatorcontrib><creatorcontrib>Liu, Jingyu</creatorcontrib><creatorcontrib>Ren, Xiang</creatorcontrib><creatorcontrib>Gao, Lianjun</creatorcontrib><creatorcontrib>Wang, Binbin</creatorcontrib><creatorcontrib>Zeng, Qiutang</creatorcontrib><creatorcontrib>Yang, Bo</creatorcontrib><creatorcontrib>Ma, Xu</creatorcontrib><creatorcontrib>Yang, Yanzong</creatorcontrib><creatorcontrib>Tu, Xin</creatorcontrib><creatorcontrib>Wang, Qing Kenneth</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Lisong</au><au>Li, Cong</au><au>Wang, Chuchu</au><au>Xia, Yunlong</au><au>Wu, Gang</au><au>Wang, Fan</au><au>Xu, Chengqi</au><au>Wang, Pengyun</au><au>Li, Xiuchun</au><au>Wang, Dan</au><au>Xiong, Xin</au><au>Bai, Ying</au><au>Liu, Mugen</au><au>Liu, Jingyu</au><au>Ren, Xiang</au><au>Gao, Lianjun</au><au>Wang, Binbin</au><au>Zeng, Qiutang</au><au>Yang, Bo</au><au>Ma, Xu</au><au>Yang, Yanzong</au><au>Tu, Xin</au><au>Wang, Qing Kenneth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population</atitle><jtitle>Human genetics</jtitle><stitle>Hum Genet</stitle><addtitle>Hum Genet</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>126</volume><issue>6</issue><spage>843</spage><epage>849</epage><pages>843-849</pages><issn>0340-6717</issn><eissn>1432-1203</eissn><coden>HUGEDQ</coden><abstract>Atrial fibrillation (AF) is the most common arrhythmia in the clinical setting and an independent risk factor for stroke. Approximately 10 million Chinese people are affected by AF, but the genetic basis is largely unknown. A recent genome-wide association study in Iceland identified association between SNP rs2200733 on 4q25 and AF; however, many independent replication studies are essential to unequivocally validate this association. To assess the association between rs2200733 and AF as well as that between rs2200733 and ischemic stroke in a mainland Chinese Han population, we carried out case-control association studies with 383 AF patients versus 851 non-AF controls and 811 ischemic stroke patients versus 688 non-stroke controls. Highly significant association was detected between rs2200733 and AF in a Chinese Han population (allelic P = 3.7 × 10⁻¹¹ with OR = 1.81; genotypic P = 4.1 × 10⁻¹² with a dominant model). When the AF cases were divided into lone AF (32.6%) and other types of AF (67.4%), significantly stronger association was found with lone AF (OR = 2.40, P = 1.3 × 10⁻⁹ compared to OR = 1.59, P = 6.2 × 10⁻⁷ for other types of AF; P = 0.02 for two ORs). No significant association was found between rs2200733 and ischemic stroke. Our results suggest that SNP rs2200733 confers a highly significant risk of AF, but not ischemic stroke, in a more representative Chinese Han population in the mainland China.</abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>19707791</pmid><doi>10.1007/s00439-009-0737-3</doi><tpages>7</tpages></addata></record> |
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| ispartof | Human genetics, 2009-12, Vol.126 (6), p.843-849 |
| issn | 0340-6717 1432-1203 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Asian Continental Ancestry Group - genetics Atrial fibrillation Atrial Fibrillation - genetics Biological and medical sciences Biomedical and Life Sciences Biomedicine Brain Ischemia - genetics Cardiac arrhythmia Cardiac dysrhythmias Cardiology. Vascular system Chromosomes Chromosomes, Human, Pair 4 Classical genetics, quantitative genetics, hybrids Female Fundamental and applied biological sciences. Psychology Gene Function Genetic aspects Genetic research Genetics of eukaryotes. Biological and molecular evolution Genomes Genomics Heart Hospitals Human Human Genetics Humans Ischemia Male Medical research Medical sciences Medicine, Experimental Metabolic Diseases Methods, theories and miscellaneous Middle Aged Molecular Medicine Original Investigation Polymorphism, Single Nucleotide Risk factors Stroke Stroke (Disease) Stroke - genetics Stroke patients |
| title | Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T10%3A22%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessment%20of%20association%20of%20rs2200733%20on%20chromosome%204q25%20with%20atrial%20fibrillation%20and%20ischemic%20stroke%20in%20a%20Chinese%20Han%20population&rft.jtitle=Human%20genetics&rft.au=Shi,%20Lisong&rft.date=2009-12-01&rft.volume=126&rft.issue=6&rft.spage=843&rft.epage=849&rft.pages=843-849&rft.issn=0340-6717&rft.eissn=1432-1203&rft.coden=HUGEDQ&rft_id=info:doi/10.1007/s00439-009-0737-3&rft_dat=%3Cgale_proqu%3EA791555699%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=215502425&rft_id=info:pmid/19707791&rft_galeid=A791555699&rfr_iscdi=true |