Intracranial Stents Being Modeled as a Porous Medium: Flow Simulation in Stented Cerebral Aneurysms
Intracranial aneurysms may be treated by flow diverters, alternatively to stents and coils combination. Numerical simulation allows the assessment of the complex nature of aneurismal flow. Endovascular devices present a rather dense and fine strut network, increasing the complexity of the meshing. W...
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Veröffentlicht in: | Annals of biomedical engineering 2011-02, Vol.39 (2), p.850-863 |
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description | Intracranial aneurysms may be treated by flow diverters, alternatively to stents and coils combination. Numerical simulation allows the assessment of the complex nature of aneurismal flow. Endovascular devices present a rather dense and fine strut network, increasing the complexity of the meshing. We propose an alternative strategy, which is based on the modeling of the device as a porous medium. Two patient-specific aneurysm data sets were reconstructed using conventional clinical setups. The aneurysms selection was done so that intra-aneurismal flow was shear driven in one and inertia driven in the other. Stents and their porous medium analog were positioned at the aneurysm neck. Physiological flow and standard boundary conditions were applied. The comparison between both approaches was done by analyzing the velocity, vorticity, and shear rate magnitudes inside the aneurysm as well as the wall shear stress (WSS) at the aneurysm surface. Simulations without device were also computed. The average flow reduction reaches 76 and 41% for the shear and inertia driven flow models, respectively. When comparing the two approaches, results show a remarkable similarity in the flow patterns and magnitude. WSS, iso-velocity surfaces and velocity on a trans-sectional plane are in fairly good agreement. The root mean squared error on the investigated parameters reaches 20% for aneurysm velocity, 30.6% for aneurysm shear rate, and 47.4% for aneurysm vorticity. It reaches 20.6% for WSS computed on the aneurysm surface. The advantages of this approach reside in its facility to implement and in the gain in computational time. Results predicted by the porous medium approach compare well with the real stent geometry model and allow predicting the main effects of the device on intra-aneurismal flow, facilitating thus the analysis. |
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A ; Stergiopulos, N</creator><creatorcontrib>Augsburger, L ; Reymond, P ; Rufenacht, D. A ; Stergiopulos, N</creatorcontrib><description>Intracranial aneurysms may be treated by flow diverters, alternatively to stents and coils combination. Numerical simulation allows the assessment of the complex nature of aneurismal flow. Endovascular devices present a rather dense and fine strut network, increasing the complexity of the meshing. We propose an alternative strategy, which is based on the modeling of the device as a porous medium. Two patient-specific aneurysm data sets were reconstructed using conventional clinical setups. The aneurysms selection was done so that intra-aneurismal flow was shear driven in one and inertia driven in the other. Stents and their porous medium analog were positioned at the aneurysm neck. Physiological flow and standard boundary conditions were applied. The comparison between both approaches was done by analyzing the velocity, vorticity, and shear rate magnitudes inside the aneurysm as well as the wall shear stress (WSS) at the aneurysm surface. Simulations without device were also computed. The average flow reduction reaches 76 and 41% for the shear and inertia driven flow models, respectively. When comparing the two approaches, results show a remarkable similarity in the flow patterns and magnitude. WSS, iso-velocity surfaces and velocity on a trans-sectional plane are in fairly good agreement. The root mean squared error on the investigated parameters reaches 20% for aneurysm velocity, 30.6% for aneurysm shear rate, and 47.4% for aneurysm vorticity. It reaches 20.6% for WSS computed on the aneurysm surface. The advantages of this approach reside in its facility to implement and in the gain in computational time. Results predicted by the porous medium approach compare well with the real stent geometry model and allow predicting the main effects of the device on intra-aneurismal flow, facilitating thus the analysis.</description><identifier>ISSN: 0090-6964</identifier><identifier>EISSN: 1573-9686</identifier><identifier>DOI: 10.1007/s10439-010-0200-6</identifier><identifier>PMID: 21042856</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Biophysics ; Blood Vessel Prosthesis ; Boundary conditions ; Cerebral aneurysm ; Cerebrovascular Circulation ; Classical Mechanics ; Computational fluid dynamics ; Computer Simulation ; Computer-Aided Design ; Equipment Design ; Equipment Failure Analysis ; Flow simulation ; Humans ; Intracranial Aneurysm - physiopathology ; Intracranial Aneurysm - surgery ; Intracranial stent ; Models, Cardiovascular ; Porosity ; Porous media ; Porous medium ; Shear stress ; Stents</subject><ispartof>Annals of biomedical engineering, 2011-02, Vol.39 (2), p.850-863</ispartof><rights>Biomedical Engineering Society 2010</rights><rights>Biomedical Engineering Society 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c535t-fabb47a5bcb774ac4493b46527eb6ed92671290de7171fac750f5b7826ed4bad3</citedby><cites>FETCH-LOGICAL-c535t-fabb47a5bcb774ac4493b46527eb6ed92671290de7171fac750f5b7826ed4bad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10439-010-0200-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10439-010-0200-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21042856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Augsburger, L</creatorcontrib><creatorcontrib>Reymond, P</creatorcontrib><creatorcontrib>Rufenacht, D. A</creatorcontrib><creatorcontrib>Stergiopulos, N</creatorcontrib><title>Intracranial Stents Being Modeled as a Porous Medium: Flow Simulation in Stented Cerebral Aneurysms</title><title>Annals of biomedical engineering</title><addtitle>Ann Biomed Eng</addtitle><addtitle>Ann Biomed Eng</addtitle><description>Intracranial aneurysms may be treated by flow diverters, alternatively to stents and coils combination. Numerical simulation allows the assessment of the complex nature of aneurismal flow. Endovascular devices present a rather dense and fine strut network, increasing the complexity of the meshing. We propose an alternative strategy, which is based on the modeling of the device as a porous medium. Two patient-specific aneurysm data sets were reconstructed using conventional clinical setups. The aneurysms selection was done so that intra-aneurismal flow was shear driven in one and inertia driven in the other. Stents and their porous medium analog were positioned at the aneurysm neck. Physiological flow and standard boundary conditions were applied. The comparison between both approaches was done by analyzing the velocity, vorticity, and shear rate magnitudes inside the aneurysm as well as the wall shear stress (WSS) at the aneurysm surface. Simulations without device were also computed. The average flow reduction reaches 76 and 41% for the shear and inertia driven flow models, respectively. When comparing the two approaches, results show a remarkable similarity in the flow patterns and magnitude. WSS, iso-velocity surfaces and velocity on a trans-sectional plane are in fairly good agreement. The root mean squared error on the investigated parameters reaches 20% for aneurysm velocity, 30.6% for aneurysm shear rate, and 47.4% for aneurysm vorticity. It reaches 20.6% for WSS computed on the aneurysm surface. The advantages of this approach reside in its facility to implement and in the gain in computational time. Results predicted by the porous medium approach compare well with the real stent geometry model and allow predicting the main effects of the device on intra-aneurismal flow, facilitating thus the analysis.</description><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Biophysics</subject><subject>Blood Vessel Prosthesis</subject><subject>Boundary conditions</subject><subject>Cerebral aneurysm</subject><subject>Cerebrovascular Circulation</subject><subject>Classical Mechanics</subject><subject>Computational fluid dynamics</subject><subject>Computer Simulation</subject><subject>Computer-Aided Design</subject><subject>Equipment Design</subject><subject>Equipment Failure Analysis</subject><subject>Flow simulation</subject><subject>Humans</subject><subject>Intracranial Aneurysm - physiopathology</subject><subject>Intracranial Aneurysm - surgery</subject><subject>Intracranial stent</subject><subject>Models, Cardiovascular</subject><subject>Porosity</subject><subject>Porous media</subject><subject>Porous medium</subject><subject>Shear stress</subject><subject>Stents</subject><issn>0090-6964</issn><issn>1573-9686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1rFTEUhoMo9lr9AW40uHE19eR74q69WC20tHDtOiQzmUvKTFKTGaT_3lymKriwq0DyvG9O8iD0lsAJAVCfCgHOdAMEGqAAjXyGNkQo1mjZyudoA6Drppb8CL0q5Q6AkJaJl-iI1iBthdyg7iLO2XbZxmBHvJt9nAs-8yHu8VXq_eh7bAu2-CbltBR85fuwTJ_x-Zh-4l2YltHOIUUc4pqt-NZn73ItO41-yQ9lKq_Ri8GOxb95XI_R7fmX79tvzeX114vt6WXTCSbmZrDOcWWF65xS3Haca-a4FFR5J32vqVSEaui9IooMtlMCBuFUS-shd7Znx-jj2nuf04_Fl9lMoXR-HG30dXjTSiIkqxVPk1zX_2kFqeSHf8i7tORYn3GAgLAqoEJkhbqcSsl-MPc5TDY_GALmYMqspkw1ZQ6mjKyZd4_Fi5t8_yfxW00F6AqUehT3Pv-9-X-t79fQYJOx-xyKud3ROiYQzVoGLfsFd82miA</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Augsburger, L</creator><creator>Reymond, P</creator><creator>Rufenacht, D. 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A</au><au>Stergiopulos, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracranial Stents Being Modeled as a Porous Medium: Flow Simulation in Stented Cerebral Aneurysms</atitle><jtitle>Annals of biomedical engineering</jtitle><stitle>Ann Biomed Eng</stitle><addtitle>Ann Biomed Eng</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>39</volume><issue>2</issue><spage>850</spage><epage>863</epage><pages>850-863</pages><issn>0090-6964</issn><eissn>1573-9686</eissn><abstract>Intracranial aneurysms may be treated by flow diverters, alternatively to stents and coils combination. Numerical simulation allows the assessment of the complex nature of aneurismal flow. Endovascular devices present a rather dense and fine strut network, increasing the complexity of the meshing. We propose an alternative strategy, which is based on the modeling of the device as a porous medium. Two patient-specific aneurysm data sets were reconstructed using conventional clinical setups. The aneurysms selection was done so that intra-aneurismal flow was shear driven in one and inertia driven in the other. Stents and their porous medium analog were positioned at the aneurysm neck. Physiological flow and standard boundary conditions were applied. The comparison between both approaches was done by analyzing the velocity, vorticity, and shear rate magnitudes inside the aneurysm as well as the wall shear stress (WSS) at the aneurysm surface. Simulations without device were also computed. The average flow reduction reaches 76 and 41% for the shear and inertia driven flow models, respectively. When comparing the two approaches, results show a remarkable similarity in the flow patterns and magnitude. WSS, iso-velocity surfaces and velocity on a trans-sectional plane are in fairly good agreement. The root mean squared error on the investigated parameters reaches 20% for aneurysm velocity, 30.6% for aneurysm shear rate, and 47.4% for aneurysm vorticity. It reaches 20.6% for WSS computed on the aneurysm surface. The advantages of this approach reside in its facility to implement and in the gain in computational time. Results predicted by the porous medium approach compare well with the real stent geometry model and allow predicting the main effects of the device on intra-aneurismal flow, facilitating thus the analysis.</abstract><cop>Boston</cop><pub>Boston : Springer US</pub><pmid>21042856</pmid><doi>10.1007/s10439-010-0200-6</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Biophysics Blood Vessel Prosthesis Boundary conditions Cerebral aneurysm Cerebrovascular Circulation Classical Mechanics Computational fluid dynamics Computer Simulation Computer-Aided Design Equipment Design Equipment Failure Analysis Flow simulation Humans Intracranial Aneurysm - physiopathology Intracranial Aneurysm - surgery Intracranial stent Models, Cardiovascular Porosity Porous media Porous medium Shear stress Stents |
title | Intracranial Stents Being Modeled as a Porous Medium: Flow Simulation in Stented Cerebral Aneurysms |
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