Vesicular distribution of Secretory Pathway Ca super(2+)-ATPase isoform 1 and a role in manganese detoxification in liver-derived polarized cells

Manganese is a trace element that is an essential co-factor in many enzymes critical to diverse biological pathways. However, excess Mn super(2+) leads to neurotoxicity, with psychiatric and motor dysfunction resembling parkinsonism. The liver is the main organ for Mn super(2+) detoxification by exc...

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Veröffentlicht in:	Biometals 2011-02, Vol.24 (1), p.159-170
Hauptverfasser:	Leitch, Sharon, Feng, Mingye, Muend, Sabina, Braiterman, Lelita T, Hubbard, Ann L, Rao, Rajini
Format:	Artikel
Sprache:	dut
Schlagworte:	Cellular Enzymes Liver Localization Manganese Pathways Position (location) Toxicity
Online-Zugang:	Volltext
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