The Detection of Mupirocin Resistance and the Distribution of Methicillin-resistant Staphylococcus aureus at the University Hospital of the West Indies, Jamaica

The objectives of this study were to determine the susceptibility of Methicillin Resistant Staphylococcus aureus (MRSA) isolates to Mupirocin and other antimicrobial agents and to record the prevalence and distribution of this organism at the University Hospital of the West Indies (UHWI). MRSA isola...

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Veröffentlicht in:West Indian medical journal 2010-10, Vol.59 (5), p.509-513
Hauptverfasser: NICHOLSON, A. M, THOMS, C, WINT, H, DIDIER, M, WILLIS, R, MCMORRIS, N, CASTLE, D, MAHARAJ, N, ORRETT, F. A
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container_end_page 513
container_issue 5
container_start_page 509
container_title West Indian medical journal
container_volume 59
creator NICHOLSON, A. M
THOMS, C
WINT, H
DIDIER, M
WILLIS, R
MCMORRIS, N
CASTLE, D
MAHARAJ, N
ORRETT, F. A
description The objectives of this study were to determine the susceptibility of Methicillin Resistant Staphylococcus aureus (MRSA) isolates to Mupirocin and other antimicrobial agents and to record the prevalence and distribution of this organism at the University Hospital of the West Indies (UHWI). MRSA isolates collected between January 1, 2008 and December 31, 2008, were tested for low and high level resistance to Mupirocin. Susceptibility testing to other antibiotics including cotrimoxazole, minocycline, tetracycline, clindamycin, erythromycin, gentamicin and vancomycin was also done. Laboratory records for all patients from whom MRSA was recovered were reviewed and data on type and source of isolates, clinical diagnosis, history of previous hospitalization and use of mupirocin were extracted. In addition, the laboratory records for 2004 and 2005 were also reviewed to determine prevalence during these periods. Seven per cent of Staphylococcus aureus isolates were resistant to methicillin (MRSA) and of these, 30% and 24% showed low level and high level resistance to mupirocin, respectively. Ninety-four per cent of MRSA strains were resistant to erythromycin while 52% showed resistance to clindamycin. Resistance to tetracycline, co-trimoxazole and minocycline was 27%, 12% and 6%, respectively, while about one-third of the isolates were resistant to gentamicin. There was no resistance to vancomycin. More than half (58%) of the isolates were from skin and soft tissue specimens while isolates from respiratory and urinary tracts and the bloodstream accounted for 19%, 13% and 4%, respectively. There has been a steady increase in prevalence from 4% in 2004 to 5% in 2007 and 7% in 2008. Resistance of MRSA to mupirocin appears to be an emerging problem at the UHWI and must be monitored carefully. There is also significant resistance to commonly used antimicrobial agents and strict adherence to antibiotic policy is required to preserve the usefulness of these agents.
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Laboratory records for all patients from whom MRSA was recovered were reviewed and data on type and source of isolates, clinical diagnosis, history of previous hospitalization and use of mupirocin were extracted. In addition, the laboratory records for 2004 and 2005 were also reviewed to determine prevalence during these periods. Seven per cent of Staphylococcus aureus isolates were resistant to methicillin (MRSA) and of these, 30% and 24% showed low level and high level resistance to mupirocin, respectively. Ninety-four per cent of MRSA strains were resistant to erythromycin while 52% showed resistance to clindamycin. Resistance to tetracycline, co-trimoxazole and minocycline was 27%, 12% and 6%, respectively, while about one-third of the isolates were resistant to gentamicin. There was no resistance to vancomycin. 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source MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial diseases
Biological and medical sciences
Cross Infection - drug therapy
Cross Infection - epidemiology
Cross Infection - microbiology
Drug Resistance, Multiple, Bacterial
General aspects
Hospitals
Human bacterial diseases
Humans
Infectious diseases
Jamaica - epidemiology
Medical sciences
Methicillin-Resistant Staphylococcus aureus - drug effects
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Mupirocin - pharmacology
Pharmacology. Drug treatments
Prevalence
Staphylococcal Infections - drug therapy
Staphylococcal Infections - epidemiology
Staphylococcal Infections - microbiology
Staphylococcal infections, streptococcal infections, pneumococcal infections
title The Detection of Mupirocin Resistance and the Distribution of Methicillin-resistant Staphylococcus aureus at the University Hospital of the West Indies, Jamaica
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