A Randomized Clinical Trial of Hydroxymethylglutaryl― Coenzyme A Reductase Inhibition for Acute Lung Injury (The HARP Study)

There is no effective pharmacological treatment for acute lung injury (ALI). Statins are a potential new therapy because they modify many of the underlying processes important in ALI. To test whether simvastatin improves physiological and biological outcomes in ALI. We conducted a randomized, double...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2011-03, Vol.183 (5), p.620-626
Hauptverfasser:	CRAIG, Thelma R, DUFFY, Martin J, SHYAMSUNDAR, Murali, MCDOWELL, Cliona, O'KANE, Cecilia M, STUART ELBORN, J, MCAULEY, Daniel F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - complications Acute Lung Injury - drug therapy Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bronchoalveolar Lavage Fluid C-Reactive Protein - drug effects Clinical trials Consent Cytokines Cytokines - drug effects Double-Blind Method Emergency and intensive respiratory care Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Inflammation Inflammation - drug therapy Inflammation - etiology Intensive care Intensive care medicine Kinases Lavage Male Medical sciences Middle Aged Mortality Multiple Organ Failure - prevention & control Patients Physiology Plasma Proteins Respiratory distress syndrome Sepsis Simvastatin - therapeutic use Statins Statistical significance Treatment Outcome Ventilators
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