Improving the topical delivery of zinc phthalocyanine using oleic acid as a penetration enhancer: in vitro permeation and retention

Topical photodynamic therapy with zinc phthalocyanine (ZnPc), second-generation photosensitizer, can be an alternative method for the treatment of skin cancer. However, ZnPc has poor penetration in the skin. This study was aimed at investigating whether the presence of oleic acid (chemical enhancer)...

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Veröffentlicht in:	Drug development and industrial pharmacy 2011-05, Vol.37 (5), p.569-575
Hauptverfasser:	da Silva, Eduardo Rodrigues, Faria de Freitas, Zaida Maria, Brito Gitirana, Lycia de, Ricci-Júnior, Eduardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Administration, Topical Animals Chemistry, Pharmaceutical - methods cutaneous delivery Drug Delivery Systems - methods Drug Stability Ear, External - metabolism Indoles - administration & dosage Indoles - chemistry Indoles - pharmacokinetics Oleic Acid - administration & dosage Oleic Acid - chemistry Oleic Acid - pharmacokinetics Organometallic Compounds - administration & dosage Organometallic Compounds - chemistry Organometallic Compounds - pharmacokinetics Permeability Photochemotherapy - methods photodynamic therapy Photosensitizer Photosensitizing Agents - administration & dosage Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacokinetics Propylene Glycol - chemistry Skin - drug effects Skin - metabolism skin cancer Skin Neoplasms - drug therapy Skin Neoplasms - metabolism Swine
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