The influence of supplemental docosahexaenoic and arachidonic acids during pregnancy and lactation on neurodevelopment at eighteen months
Abstract Docosahexaenoic acid (DHA) and arachidonic acid (AA) are important for neurodevelopment. The effects of DHA (220 mg/day, n =41), DHA+AA (220 mg/day, n =39) or placebo ( n =34) during pregnancy and lactation on neurodevelopment at 18 months, and the relations between umbilical cord DHA, AA a...
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| Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2011-05, Vol.84 (5), p.139-146 |
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| container_title | Prostaglandins, leukotrienes and essential fatty acids |
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| creator | van Goor, Saskia A Janneke Dijck-Brouwer, D.A Erwich, Jan Jaap H.M Schaafsma, Anne Hadders-Algra, Mijna |
| description | Abstract Docosahexaenoic acid (DHA) and arachidonic acid (AA) are important for neurodevelopment. The effects of DHA (220 mg/day, n =41), DHA+AA (220 mg/day, n =39) or placebo ( n =34) during pregnancy and lactation on neurodevelopment at 18 months, and the relations between umbilical cord DHA, AA and Mead acid and neurodevelopment were studied. An age-specific, standardized neurological assessment for the evaluation of minor neurological dysfunction (MND), and the Bayley Scales of Infant Development (BSID) were used. The intervention did not influence any of the outcomes. Umbilical venous (UV) Mead acid was negatively and n-6 fatty acids were weakly positively associated to the BSID mental developmental index. Children with simple MND had lower UV DHA compared to normally classified children. We conclude that relatively short-term maternal DHA or DHA+AA supplementation does not influence neurodevelopment at toddler age, although some parameters of brain development are related to perinatal DHA and AA status. |
| doi_str_mv | 10.1016/j.plefa.2011.01.002 |
| format | Article |
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The effects of DHA (220 mg/day, n =41), DHA+AA (220 mg/day, n =39) or placebo ( n =34) during pregnancy and lactation on neurodevelopment at 18 months, and the relations between umbilical cord DHA, AA and Mead acid and neurodevelopment were studied. An age-specific, standardized neurological assessment for the evaluation of minor neurological dysfunction (MND), and the Bayley Scales of Infant Development (BSID) were used. The intervention did not influence any of the outcomes. Umbilical venous (UV) Mead acid was negatively and n-6 fatty acids were weakly positively associated to the BSID mental developmental index. Children with simple MND had lower UV DHA compared to normally classified children. We conclude that relatively short-term maternal DHA or DHA+AA supplementation does not influence neurodevelopment at toddler age, although some parameters of brain development are related to perinatal DHA and AA status.</description><identifier>ISSN: 0952-3278</identifier><identifier>EISSN: 1532-2823</identifier><identifier>DOI: 10.1016/j.plefa.2011.01.002</identifier><identifier>PMID: 21316208</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Advanced Basic Science ; Arachidonic acid ; Arachidonic Acid - administration & dosage ; Association ; Bayley Scales of Infant Development ; Biological and medical sciences ; BSID ; Child ; Dietary Supplements ; Docosahexaenoic acid ; Docosahexaenoic Acids - administration & dosage ; Endocrinology & Metabolism ; Female ; Fish oil ; Fundamental and applied biological sciences. Psychology ; Hempel ; Humans ; Infant ; Intervention ; Lactation ; Mead acid ; Motor Activity - drug effects ; Nervous System Diseases - epidemiology ; Nervous System Diseases - metabolism ; Nervous System Diseases - prevention & control ; Pregnancy ; Prenatal Nutritional Physiological Phenomena ; Toddler ; Umbilical Cord - metabolism ; Vertebrates: endocrinology</subject><ispartof>Prostaglandins, leukotrienes and essential fatty acids, 2011-05, Vol.84 (5), p.139-146</ispartof><rights>Elsevier Ltd</rights><rights>2011 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd. 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The effects of DHA (220 mg/day, n =41), DHA+AA (220 mg/day, n =39) or placebo ( n =34) during pregnancy and lactation on neurodevelopment at 18 months, and the relations between umbilical cord DHA, AA and Mead acid and neurodevelopment were studied. An age-specific, standardized neurological assessment for the evaluation of minor neurological dysfunction (MND), and the Bayley Scales of Infant Development (BSID) were used. The intervention did not influence any of the outcomes. Umbilical venous (UV) Mead acid was negatively and n-6 fatty acids were weakly positively associated to the BSID mental developmental index. Children with simple MND had lower UV DHA compared to normally classified children. We conclude that relatively short-term maternal DHA or DHA+AA supplementation does not influence neurodevelopment at toddler age, although some parameters of brain development are related to perinatal DHA and AA status.</description><subject>Advanced Basic Science</subject><subject>Arachidonic acid</subject><subject>Arachidonic Acid - administration & dosage</subject><subject>Association</subject><subject>Bayley Scales of Infant Development</subject><subject>Biological and medical sciences</subject><subject>BSID</subject><subject>Child</subject><subject>Dietary Supplements</subject><subject>Docosahexaenoic acid</subject><subject>Docosahexaenoic Acids - administration & dosage</subject><subject>Endocrinology & Metabolism</subject><subject>Female</subject><subject>Fish oil</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hempel</subject><subject>Humans</subject><subject>Infant</subject><subject>Intervention</subject><subject>Lactation</subject><subject>Mead acid</subject><subject>Motor Activity - drug effects</subject><subject>Nervous System Diseases - epidemiology</subject><subject>Nervous System Diseases - metabolism</subject><subject>Nervous System Diseases - prevention & control</subject><subject>Pregnancy</subject><subject>Prenatal Nutritional Physiological Phenomena</subject><subject>Toddler</subject><subject>Umbilical Cord - metabolism</subject><subject>Vertebrates: endocrinology</subject><issn>0952-3278</issn><issn>1532-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks2KFDEUhQtRnHb0CQTJRlx1e5NUqlILhWHwDwZcOK5DOrnVnTaVlEnVYD-Cb21qulVwI1wIge8cknNuVT2nsKFAm9eHzeix1xsGlG6gDLAH1YoKztZMMv6wWkEn2JqzVl5UT3I-QCEorR9XF4xy2jCQq-rn7R6JC72fMRgksSd5HovvgGHSnthoYtZ7_KExRGeIDpbopM3e2RiWu3E2EzsnF3ZkTLgLOpjjPea1mfTkYiBlAs4pWrxDH8fFmuiJoNvtJ8RAhhimfX5aPeq1z_jsfF5WX9-_u73-uL75_OHT9dXN2tRSTmuxFXXbWhCi57qFljfQWcp6g235eb-1jdhKUVghraCC8pYbaxnUPTQ16zp-Wb06-Y4pfp8xT2pw2aD3OmCcs5INSMm6ui4kP5EmxZwT9mpMbtDpqCiopQJ1UPcVqKUCBWWAFdWLs_-8HdD-0fzOvAAvz4DORvs-lchc_svVICnjULg3Jw5LGncOk8rGLS1Zl9BMykb3n4e8_UdvvCulaf8Nj5gPcU6hBK2oykyB-rJsy7IslJZFoQ3wXwTyvBo</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>van Goor, Saskia A</creator><creator>Janneke Dijck-Brouwer, D.A</creator><creator>Erwich, Jan Jaap H.M</creator><creator>Schaafsma, Anne</creator><creator>Hadders-Algra, Mijna</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110501</creationdate><title>The influence of supplemental docosahexaenoic and arachidonic acids during pregnancy and lactation on neurodevelopment at eighteen months</title><author>van Goor, Saskia A ; Janneke Dijck-Brouwer, D.A ; Erwich, Jan Jaap H.M ; Schaafsma, Anne ; Hadders-Algra, Mijna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-5b5477d055f3a7073609d12fce7532fbd65b85c4858d5151373cdd204f0642993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Advanced Basic Science</topic><topic>Arachidonic acid</topic><topic>Arachidonic Acid - administration & dosage</topic><topic>Association</topic><topic>Bayley Scales of Infant Development</topic><topic>Biological and medical sciences</topic><topic>BSID</topic><topic>Child</topic><topic>Dietary Supplements</topic><topic>Docosahexaenoic acid</topic><topic>Docosahexaenoic Acids - administration & dosage</topic><topic>Endocrinology & Metabolism</topic><topic>Female</topic><topic>Fish oil</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hempel</topic><topic>Humans</topic><topic>Infant</topic><topic>Intervention</topic><topic>Lactation</topic><topic>Mead acid</topic><topic>Motor Activity - drug effects</topic><topic>Nervous System Diseases - epidemiology</topic><topic>Nervous System Diseases - metabolism</topic><topic>Nervous System Diseases - prevention & control</topic><topic>Pregnancy</topic><topic>Prenatal Nutritional Physiological Phenomena</topic><topic>Toddler</topic><topic>Umbilical Cord - metabolism</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Goor, Saskia A</creatorcontrib><creatorcontrib>Janneke Dijck-Brouwer, D.A</creatorcontrib><creatorcontrib>Erwich, Jan Jaap H.M</creatorcontrib><creatorcontrib>Schaafsma, Anne</creatorcontrib><creatorcontrib>Hadders-Algra, Mijna</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Goor, Saskia A</au><au>Janneke Dijck-Brouwer, D.A</au><au>Erwich, Jan Jaap H.M</au><au>Schaafsma, Anne</au><au>Hadders-Algra, Mijna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of supplemental docosahexaenoic and arachidonic acids during pregnancy and lactation on neurodevelopment at eighteen months</atitle><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>84</volume><issue>5</issue><spage>139</spage><epage>146</epage><pages>139-146</pages><issn>0952-3278</issn><eissn>1532-2823</eissn><abstract>Abstract Docosahexaenoic acid (DHA) and arachidonic acid (AA) are important for neurodevelopment. The effects of DHA (220 mg/day, n =41), DHA+AA (220 mg/day, n =39) or placebo ( n =34) during pregnancy and lactation on neurodevelopment at 18 months, and the relations between umbilical cord DHA, AA and Mead acid and neurodevelopment were studied. An age-specific, standardized neurological assessment for the evaluation of minor neurological dysfunction (MND), and the Bayley Scales of Infant Development (BSID) were used. The intervention did not influence any of the outcomes. Umbilical venous (UV) Mead acid was negatively and n-6 fatty acids were weakly positively associated to the BSID mental developmental index. Children with simple MND had lower UV DHA compared to normally classified children. 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Advanced Basic Science Arachidonic acid Arachidonic Acid - administration & dosage Association Bayley Scales of Infant Development Biological and medical sciences BSID Child Dietary Supplements Docosahexaenoic acid Docosahexaenoic Acids - administration & dosage Endocrinology & Metabolism Female Fish oil Fundamental and applied biological sciences. Psychology Hempel Humans Infant Intervention Lactation Mead acid Motor Activity - drug effects Nervous System Diseases - epidemiology Nervous System Diseases - metabolism Nervous System Diseases - prevention & control Pregnancy Prenatal Nutritional Physiological Phenomena Toddler Umbilical Cord - metabolism Vertebrates: endocrinology |
| title | The influence of supplemental docosahexaenoic and arachidonic acids during pregnancy and lactation on neurodevelopment at eighteen months |
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