Increased MAPK and NF-κB expression of Langerhans cells is dependent on TLR2 and TLR4, and increased IRF-3 expression is partially dependent on TLR4 following UV exposure

Toll-like receptors (TLRs) and epidermal Langerhans cells (LCs) play a crucial role in innate and adaptive immunity. To date, the pattern of TLR expression has not been fully analyzed. The effects of ultraviolet (UV) light on TLR expression and the downstream signaling cascades of human LC have not...

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Veröffentlicht in:	Molecular medicine reports 2011-05, Vol.4 (3), p.541-546
Hauptverfasser:	Wang, Xiaoyong, Bi, Zhigang, Wang, Yungui, Wang, Yanfei
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Survival - radiation effects Cells, Cultured Flow Cytometry Gene Expression Regulation - radiation effects Humans Interferon Regulatory Factor-3 - genetics Interferon Regulatory Factor-3 - metabolism Langerhans Cells - cytology Langerhans Cells - enzymology Langerhans Cells - radiation effects Male Mitogen-Activated Protein Kinases - metabolism NF-kappa B - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Transcription, Genetic - radiation effects Ultraviolet Rays
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