Histopathologic evaluation of subcutaneous tissue response to three endodontic sealers in rats
The aim of this study was to evaluate the subcutaneous biocompatibility of three root canal sealers in rats. Thirty Wistar rats were divided into three groups according to three time periods (15, 30 and 60 days). Sterilized polyethylene tubes filled with root canal sealers (AH Plus, Epiphany & G...
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| Veröffentlicht in: | Journal of Oral Science 2011, Vol.53(1), pp.15-21 |
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| container_title | Journal of Oral Science |
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| creator | Farhad, Ali R. Hasheminia, Seyedmohsen Razavi, Seyedmohammad Feizi, Mostafa |
| description | The aim of this study was to evaluate the subcutaneous biocompatibility of three root canal sealers in rats. Thirty Wistar rats were divided into three groups according to three time periods (15, 30 and 60 days). Sterilized polyethylene tubes filled with root canal sealers (AH Plus, Epiphany & Grossman), and one empty tube (control) were implanted into four separate dorsal regions in each rat. At the end of each study period, 10 animals were sacrificed, and histologic sections of connective tissue at the open ends of the tubes were prepared. Severity of tissue inflammatory response was assessed. Grossman endodontic sealer had the most severe inflammatory response followed by the AH Plus, Epiphany and control groups. The tissue inflammatory response of the Epiphany and AH Plus sealers was not significantly different. Thus, Epiphany sealer showed acceptable biocompatibility when tested on rat subcutaneous tissue. (J Oral Sci 53, 15-21, 2011) |
| doi_str_mv | 10.2334/josnusd.53.15 |
| format | Article |
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Thirty Wistar rats were divided into three groups according to three time periods (15, 30 and 60 days). Sterilized polyethylene tubes filled with root canal sealers (AH Plus, Epiphany & Grossman), and one empty tube (control) were implanted into four separate dorsal regions in each rat. At the end of each study period, 10 animals were sacrificed, and histologic sections of connective tissue at the open ends of the tubes were prepared. Severity of tissue inflammatory response was assessed. Grossman endodontic sealer had the most severe inflammatory response followed by the AH Plus, Epiphany and control groups. The tissue inflammatory response of the Epiphany and AH Plus sealers was not significantly different. Thus, Epiphany sealer showed acceptable biocompatibility when tested on rat subcutaneous tissue. (J Oral Sci 53, 15-21, 2011)</description><identifier>ISSN: 1343-4934</identifier><identifier>EISSN: 1880-4926</identifier><identifier>DOI: 10.2334/josnusd.53.15</identifier><identifier>PMID: 21467810</identifier><language>eng</language><publisher>Japan: Nihon University School of Dentistry</publisher><subject>Animals ; Connective Tissue - drug effects ; Connective Tissue - pathology ; Dentistry ; endodontic sealers ; Epoxy Resins - toxicity ; Male ; Materials Testing ; Rats ; Rats, Wistar ; Root Canal Filling Materials - toxicity ; subcutaneous implantation ; Subcutaneous Tissue - drug effects ; Subcutaneous Tissue - pathology ; tissue reaction ; Zinc Oxide-Eugenol Cement - toxicity</subject><ispartof>Journal of Oral Science, 2011, Vol.53(1), pp.15-21</ispartof><rights>2011 by Nihon University School of Dentistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4965-879988ebe6c6e4f5e4f214c0984c646a3b72eb86213ba94d17cf087c30fd39b03</citedby><cites>FETCH-LOGICAL-c4965-879988ebe6c6e4f5e4f214c0984c646a3b72eb86213ba94d17cf087c30fd39b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,4025,27928,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21467810$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farhad, Ali R.</creatorcontrib><creatorcontrib>Hasheminia, Seyedmohsen</creatorcontrib><creatorcontrib>Razavi, Seyedmohammad</creatorcontrib><creatorcontrib>Feizi, Mostafa</creatorcontrib><title>Histopathologic evaluation of subcutaneous tissue response to three endodontic sealers in rats</title><title>Journal of Oral Science</title><addtitle>J Oral Sci</addtitle><description>The aim of this study was to evaluate the subcutaneous biocompatibility of three root canal sealers in rats. Thirty Wistar rats were divided into three groups according to three time periods (15, 30 and 60 days). Sterilized polyethylene tubes filled with root canal sealers (AH Plus, Epiphany & Grossman), and one empty tube (control) were implanted into four separate dorsal regions in each rat. At the end of each study period, 10 animals were sacrificed, and histologic sections of connective tissue at the open ends of the tubes were prepared. Severity of tissue inflammatory response was assessed. Grossman endodontic sealer had the most severe inflammatory response followed by the AH Plus, Epiphany and control groups. The tissue inflammatory response of the Epiphany and AH Plus sealers was not significantly different. Thus, Epiphany sealer showed acceptable biocompatibility when tested on rat subcutaneous tissue. (J Oral Sci 53, 15-21, 2011)</description><subject>Animals</subject><subject>Connective Tissue - drug effects</subject><subject>Connective Tissue - pathology</subject><subject>Dentistry</subject><subject>endodontic sealers</subject><subject>Epoxy Resins - toxicity</subject><subject>Male</subject><subject>Materials Testing</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Root Canal Filling Materials - toxicity</subject><subject>subcutaneous implantation</subject><subject>Subcutaneous Tissue - drug effects</subject><subject>Subcutaneous Tissue - pathology</subject><subject>tissue reaction</subject><subject>Zinc Oxide-Eugenol Cement - toxicity</subject><issn>1343-4934</issn><issn>1880-4926</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM1LxDAQxYMorl9Hr5Kbp65Jk6bpUUVdQfCiV0OaTne7dJs1kwr-90a6LniYmQfzm8fwCLnkbJ4LIW_WHocRm3kh5rw4ICdca5bJKleHSQspkhZyRk4R14zJXJXFMZnlXKpSc3ZCPhYdRr-1ceV7v-wchS_bjzZ2fqC-pTjWbox2AD8ijR3iCDQAbv2AQKOncRUAKAyNb_wQ0zmC7SEg7QYabMRzctTaHuFiN8_I--PD2_0ie3l9er6_fcmcrFSR6bKqtIYalFMg2yJVetGxSkunpLKiLnOotcq5qG0lG166lunSCdY2oqqZOCPXk-82-M8RMJpNhw76fnrdaMW0zpnKE5lNpAseMUBrtqHb2PBtODO_iZpdoqYQhheJv9o5j_UGmj39F2EC7iZgjdEuYQ_YkPLo4Z_d1HixX7qVDQYG8QOCfo22</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Farhad, Ali R.</creator><creator>Hasheminia, Seyedmohsen</creator><creator>Razavi, Seyedmohammad</creator><creator>Feizi, Mostafa</creator><general>Nihon University School of Dentistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Histopathologic evaluation of subcutaneous tissue response to three endodontic sealers in rats</title><author>Farhad, Ali R. ; Hasheminia, Seyedmohsen ; Razavi, Seyedmohammad ; Feizi, Mostafa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4965-879988ebe6c6e4f5e4f214c0984c646a3b72eb86213ba94d17cf087c30fd39b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Connective Tissue - drug effects</topic><topic>Connective Tissue - pathology</topic><topic>Dentistry</topic><topic>endodontic sealers</topic><topic>Epoxy Resins - toxicity</topic><topic>Male</topic><topic>Materials Testing</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Root Canal Filling Materials - toxicity</topic><topic>subcutaneous implantation</topic><topic>Subcutaneous Tissue - drug effects</topic><topic>Subcutaneous Tissue - pathology</topic><topic>tissue reaction</topic><topic>Zinc Oxide-Eugenol Cement - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farhad, Ali R.</creatorcontrib><creatorcontrib>Hasheminia, Seyedmohsen</creatorcontrib><creatorcontrib>Razavi, Seyedmohammad</creatorcontrib><creatorcontrib>Feizi, Mostafa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Oral Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farhad, Ali R.</au><au>Hasheminia, Seyedmohsen</au><au>Razavi, Seyedmohammad</au><au>Feizi, Mostafa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histopathologic evaluation of subcutaneous tissue response to three endodontic sealers in rats</atitle><jtitle>Journal of Oral Science</jtitle><addtitle>J Oral Sci</addtitle><date>2011</date><risdate>2011</risdate><volume>53</volume><issue>1</issue><spage>15</spage><epage>21</epage><pages>15-21</pages><issn>1343-4934</issn><eissn>1880-4926</eissn><abstract>The aim of this study was to evaluate the subcutaneous biocompatibility of three root canal sealers in rats. 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| ispartof | Journal of Oral Science, 2011, Vol.53(1), pp.15-21 |
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| subjects | Animals Connective Tissue - drug effects Connective Tissue - pathology Dentistry endodontic sealers Epoxy Resins - toxicity Male Materials Testing Rats Rats, Wistar Root Canal Filling Materials - toxicity subcutaneous implantation Subcutaneous Tissue - drug effects Subcutaneous Tissue - pathology tissue reaction Zinc Oxide-Eugenol Cement - toxicity |
| title | Histopathologic evaluation of subcutaneous tissue response to three endodontic sealers in rats |
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