Pineal Parenchymal Tumors: Management with Interstitial Iodine-125 Radiosurgery
Purpose: To evaluate the efficacy of interstitial radiosurgery (IRS) for pineal parenchymal tumors (PPTs). Patients and Methods: 18 consecutively admitted patients (twelve male and six female, age range 6–68 years, median age 34 years) with PPTs (eight pineocytomas, ten malignant PPTs) were treated...
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Veröffentlicht in: | Strahlentherapie und Onkologie 2010-03, Vol.186 (3), p.127-134 |
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creator | Maarouf, Mohammad El Majdoub, Faycal Bührle, Christian Voges, Jürgen Lehrke, Ralph Kocher, Martin Hunsche, Stefan Treuer, Harald Sturm, Volker |
description | Purpose:
To evaluate the efficacy of interstitial radiosurgery (IRS) for pineal parenchymal tumors (PPTs).
Patients and Methods:
18 consecutively admitted patients (twelve male and six female, age range 6–68 years, median age 34 years) with PPTs (eight pineocytomas, ten malignant PPTs) were treated at the authors’ institution with IRS using stereotactically guided iodine-125 seed implantation (
125
I-IRS) as either primary or salvage therapy. The cumulative tumor surface dose ranged from 40 to 64 Gy. Adjuvant radiotherapy of the whole brain or the craniospine was done in patients with grade III and grade IV PPT. The median follow-up period was 57.4 months (range 6–134 months).
Results:
Overall actuarial 5- and 8-year survival rates after IRS were 100% and 86% for pineocytomas, and the overall actuarial 5-year survival rate was 78% for high-grade PPTs. Follow-up magnetic resonance imaging showed complete remission in 72% (13/18) and partial remission in 28% (5/18) of the cases. One patient developed an out-of-field relapse 4 years after partial remission of a pineocytoma, which had already been treated with IRS. There was no treatment-related mortality. Treatment-related morbidity occurred in two patients only.
Conclusion:
This study indicates that stereotactic
125
I-IRS for the management of PPTs is quite efficient and safe. Due to the low rate of side effects, IRS may develop into an attractive alternative to microsurgery in de novo diagnosed pineocytomas. In malignant PPTs, IRS may be routinely applied in a multimodality treatment schedule supplementary to conventional irradiation. |
doi_str_mv | 10.1007/s00066-010-2096-3 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_860881146</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2278069441</sourcerecordid><originalsourceid>FETCH-LOGICAL-c322t-413e26d2f30ebcf680ffd26b94a9d11b642c848428022a906cfa5251b5a1b8453</originalsourceid><addsrcrecordid>eNp1kE1LAzEQhoMotlZ_QC8iXjxFZybZNDmK-AUFe6jgLWR3s9rS3a1J99B_b8pWBcHTDMwz7wwPY2OEawSY3EQAUIoDAicwiosDNkQpDAdj3g7ZEHBi-AQzPWAnMS4BUEkjj9mAQAijSQ7ZeLZovFtdzFzwTfGxrVM_7-o2xFN2VLlV9Gf7OmKvD_fzuyc-fXl8vrud8kIQbbhE4UmVVAnweVEpDVVVksqNdKZEzJWkQkstSQORM6CKymWUYZ45zLXMxIhd9bnr0H52Pm5svYiFX61c49suWq1Aa0SpEnn5h1y2XWjSc1ZnwhhUGSUIe6gIbYzBV3YdFrULW4tgd9Zsb80ma3ZnzYq0c74P7vLalz8b35oSQD0Q06h59-H38v-pX2MddDY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>853991652</pqid></control><display><type>article</type><title>Pineal Parenchymal Tumors: Management with Interstitial Iodine-125 Radiosurgery</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Maarouf, Mohammad ; El Majdoub, Faycal ; Bührle, Christian ; Voges, Jürgen ; Lehrke, Ralph ; Kocher, Martin ; Hunsche, Stefan ; Treuer, Harald ; Sturm, Volker</creator><creatorcontrib>Maarouf, Mohammad ; El Majdoub, Faycal ; Bührle, Christian ; Voges, Jürgen ; Lehrke, Ralph ; Kocher, Martin ; Hunsche, Stefan ; Treuer, Harald ; Sturm, Volker</creatorcontrib><description>Purpose:
To evaluate the efficacy of interstitial radiosurgery (IRS) for pineal parenchymal tumors (PPTs).
Patients and Methods:
18 consecutively admitted patients (twelve male and six female, age range 6–68 years, median age 34 years) with PPTs (eight pineocytomas, ten malignant PPTs) were treated at the authors’ institution with IRS using stereotactically guided iodine-125 seed implantation (
125
I-IRS) as either primary or salvage therapy. The cumulative tumor surface dose ranged from 40 to 64 Gy. Adjuvant radiotherapy of the whole brain or the craniospine was done in patients with grade III and grade IV PPT. The median follow-up period was 57.4 months (range 6–134 months).
Results:
Overall actuarial 5- and 8-year survival rates after IRS were 100% and 86% for pineocytomas, and the overall actuarial 5-year survival rate was 78% for high-grade PPTs. Follow-up magnetic resonance imaging showed complete remission in 72% (13/18) and partial remission in 28% (5/18) of the cases. One patient developed an out-of-field relapse 4 years after partial remission of a pineocytoma, which had already been treated with IRS. There was no treatment-related mortality. Treatment-related morbidity occurred in two patients only.
Conclusion:
This study indicates that stereotactic
125
I-IRS for the management of PPTs is quite efficient and safe. Due to the low rate of side effects, IRS may develop into an attractive alternative to microsurgery in de novo diagnosed pineocytomas. In malignant PPTs, IRS may be routinely applied in a multimodality treatment schedule supplementary to conventional irradiation.</description><identifier>ISSN: 0179-7158</identifier><identifier>EISSN: 1439-099X</identifier><identifier>DOI: 10.1007/s00066-010-2096-3</identifier><identifier>PMID: 20339824</identifier><language>eng</language><publisher>Munchen: Urban and Vogel</publisher><subject>Adolescent ; Adult ; Aged ; Brachytherapy - methods ; Child ; Current Discussion ; Female ; Humans ; Iodine Radioisotopes - therapeutic use ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Pinealoma - diagnosis ; Pinealoma - surgery ; Radiopharmaceuticals - therapeutic use ; Radiosurgery - methods ; Radiotherapy ; Radiotherapy Dosage ; Treatment Outcome ; Young Adult</subject><ispartof>Strahlentherapie und Onkologie, 2010-03, Vol.186 (3), p.127-134</ispartof><rights>Urban & Vogel, Muenchen 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c322t-413e26d2f30ebcf680ffd26b94a9d11b642c848428022a906cfa5251b5a1b8453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00066-010-2096-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00066-010-2096-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20339824$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maarouf, Mohammad</creatorcontrib><creatorcontrib>El Majdoub, Faycal</creatorcontrib><creatorcontrib>Bührle, Christian</creatorcontrib><creatorcontrib>Voges, Jürgen</creatorcontrib><creatorcontrib>Lehrke, Ralph</creatorcontrib><creatorcontrib>Kocher, Martin</creatorcontrib><creatorcontrib>Hunsche, Stefan</creatorcontrib><creatorcontrib>Treuer, Harald</creatorcontrib><creatorcontrib>Sturm, Volker</creatorcontrib><title>Pineal Parenchymal Tumors: Management with Interstitial Iodine-125 Radiosurgery</title><title>Strahlentherapie und Onkologie</title><addtitle>Strahlenther Onkol</addtitle><addtitle>Strahlenther Onkol</addtitle><description>Purpose:
To evaluate the efficacy of interstitial radiosurgery (IRS) for pineal parenchymal tumors (PPTs).
Patients and Methods:
18 consecutively admitted patients (twelve male and six female, age range 6–68 years, median age 34 years) with PPTs (eight pineocytomas, ten malignant PPTs) were treated at the authors’ institution with IRS using stereotactically guided iodine-125 seed implantation (
125
I-IRS) as either primary or salvage therapy. The cumulative tumor surface dose ranged from 40 to 64 Gy. Adjuvant radiotherapy of the whole brain or the craniospine was done in patients with grade III and grade IV PPT. The median follow-up period was 57.4 months (range 6–134 months).
Results:
Overall actuarial 5- and 8-year survival rates after IRS were 100% and 86% for pineocytomas, and the overall actuarial 5-year survival rate was 78% for high-grade PPTs. Follow-up magnetic resonance imaging showed complete remission in 72% (13/18) and partial remission in 28% (5/18) of the cases. One patient developed an out-of-field relapse 4 years after partial remission of a pineocytoma, which had already been treated with IRS. There was no treatment-related mortality. Treatment-related morbidity occurred in two patients only.
Conclusion:
This study indicates that stereotactic
125
I-IRS for the management of PPTs is quite efficient and safe. Due to the low rate of side effects, IRS may develop into an attractive alternative to microsurgery in de novo diagnosed pineocytomas. In malignant PPTs, IRS may be routinely applied in a multimodality treatment schedule supplementary to conventional irradiation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Brachytherapy - methods</subject><subject>Child</subject><subject>Current Discussion</subject><subject>Female</subject><subject>Humans</subject><subject>Iodine Radioisotopes - therapeutic use</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Pinealoma - diagnosis</subject><subject>Pinealoma - surgery</subject><subject>Radiopharmaceuticals - therapeutic use</subject><subject>Radiosurgery - methods</subject><subject>Radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0179-7158</issn><issn>1439-099X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kE1LAzEQhoMotlZ_QC8iXjxFZybZNDmK-AUFe6jgLWR3s9rS3a1J99B_b8pWBcHTDMwz7wwPY2OEawSY3EQAUIoDAicwiosDNkQpDAdj3g7ZEHBi-AQzPWAnMS4BUEkjj9mAQAijSQ7ZeLZovFtdzFzwTfGxrVM_7-o2xFN2VLlV9Gf7OmKvD_fzuyc-fXl8vrud8kIQbbhE4UmVVAnweVEpDVVVksqNdKZEzJWkQkstSQORM6CKymWUYZ45zLXMxIhd9bnr0H52Pm5svYiFX61c49suWq1Aa0SpEnn5h1y2XWjSc1ZnwhhUGSUIe6gIbYzBV3YdFrULW4tgd9Zsb80ma3ZnzYq0c74P7vLalz8b35oSQD0Q06h59-H38v-pX2MddDY</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Maarouf, Mohammad</creator><creator>El Majdoub, Faycal</creator><creator>Bührle, Christian</creator><creator>Voges, Jürgen</creator><creator>Lehrke, Ralph</creator><creator>Kocher, Martin</creator><creator>Hunsche, Stefan</creator><creator>Treuer, Harald</creator><creator>Sturm, Volker</creator><general>Urban and Vogel</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20100301</creationdate><title>Pineal Parenchymal Tumors</title><author>Maarouf, Mohammad ; El Majdoub, Faycal ; Bührle, Christian ; Voges, Jürgen ; Lehrke, Ralph ; Kocher, Martin ; Hunsche, Stefan ; Treuer, Harald ; Sturm, Volker</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c322t-413e26d2f30ebcf680ffd26b94a9d11b642c848428022a906cfa5251b5a1b8453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Brachytherapy - methods</topic><topic>Child</topic><topic>Current Discussion</topic><topic>Female</topic><topic>Humans</topic><topic>Iodine Radioisotopes - therapeutic use</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Pinealoma - diagnosis</topic><topic>Pinealoma - surgery</topic><topic>Radiopharmaceuticals - therapeutic use</topic><topic>Radiosurgery - methods</topic><topic>Radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maarouf, Mohammad</creatorcontrib><creatorcontrib>El Majdoub, Faycal</creatorcontrib><creatorcontrib>Bührle, Christian</creatorcontrib><creatorcontrib>Voges, Jürgen</creatorcontrib><creatorcontrib>Lehrke, Ralph</creatorcontrib><creatorcontrib>Kocher, Martin</creatorcontrib><creatorcontrib>Hunsche, Stefan</creatorcontrib><creatorcontrib>Treuer, Harald</creatorcontrib><creatorcontrib>Sturm, Volker</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Strahlentherapie und Onkologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maarouf, Mohammad</au><au>El Majdoub, Faycal</au><au>Bührle, Christian</au><au>Voges, Jürgen</au><au>Lehrke, Ralph</au><au>Kocher, Martin</au><au>Hunsche, Stefan</au><au>Treuer, Harald</au><au>Sturm, Volker</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pineal Parenchymal Tumors: Management with Interstitial Iodine-125 Radiosurgery</atitle><jtitle>Strahlentherapie und Onkologie</jtitle><stitle>Strahlenther Onkol</stitle><addtitle>Strahlenther Onkol</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>186</volume><issue>3</issue><spage>127</spage><epage>134</epage><pages>127-134</pages><issn>0179-7158</issn><eissn>1439-099X</eissn><abstract>Purpose:
To evaluate the efficacy of interstitial radiosurgery (IRS) for pineal parenchymal tumors (PPTs).
Patients and Methods:
18 consecutively admitted patients (twelve male and six female, age range 6–68 years, median age 34 years) with PPTs (eight pineocytomas, ten malignant PPTs) were treated at the authors’ institution with IRS using stereotactically guided iodine-125 seed implantation (
125
I-IRS) as either primary or salvage therapy. The cumulative tumor surface dose ranged from 40 to 64 Gy. Adjuvant radiotherapy of the whole brain or the craniospine was done in patients with grade III and grade IV PPT. The median follow-up period was 57.4 months (range 6–134 months).
Results:
Overall actuarial 5- and 8-year survival rates after IRS were 100% and 86% for pineocytomas, and the overall actuarial 5-year survival rate was 78% for high-grade PPTs. Follow-up magnetic resonance imaging showed complete remission in 72% (13/18) and partial remission in 28% (5/18) of the cases. One patient developed an out-of-field relapse 4 years after partial remission of a pineocytoma, which had already been treated with IRS. There was no treatment-related mortality. Treatment-related morbidity occurred in two patients only.
Conclusion:
This study indicates that stereotactic
125
I-IRS for the management of PPTs is quite efficient and safe. Due to the low rate of side effects, IRS may develop into an attractive alternative to microsurgery in de novo diagnosed pineocytomas. In malignant PPTs, IRS may be routinely applied in a multimodality treatment schedule supplementary to conventional irradiation.</abstract><cop>Munchen</cop><pub>Urban and Vogel</pub><pmid>20339824</pmid><doi>10.1007/s00066-010-2096-3</doi><tpages>8</tpages></addata></record> |
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source | MEDLINE; SpringerNature Journals |
subjects | Adolescent Adult Aged Brachytherapy - methods Child Current Discussion Female Humans Iodine Radioisotopes - therapeutic use Male Medicine Medicine & Public Health Middle Aged Oncology Pinealoma - diagnosis Pinealoma - surgery Radiopharmaceuticals - therapeutic use Radiosurgery - methods Radiotherapy Radiotherapy Dosage Treatment Outcome Young Adult |
title | Pineal Parenchymal Tumors: Management with Interstitial Iodine-125 Radiosurgery |
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