Evaluation on hepatotoxicity caused by Dioscorea bulbifera based on analysis of bile acids

Metabolic profile of bile acids was used to evaluate hepatotoxicity of mice caused by ethanol extraction of Dioscorea bulbifera L. (ethanol extraction, ET) and diosbulbin B (DB), separately. Ultra-performance liquid chromatography coupled with quadrupole mass spectrometry (UPLC-MS) was applied to de...

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Veröffentlicht in:	Yao hsüeh hsüeh pao 2011-01, Vol.46 (1), p.39-44
Hauptverfasser:	Xu, Ying, Chen, Chong-Chong, Yang, Li, Wang, Jun-Ming, Ji, Li-Li, Wang, Zheng-Tao, Hu, Zhi-Bi
Format:	Artikel
Sprache:	chi
Schlagworte:	Animals Bile Acids and Salts - metabolism Chemical and Drug Induced Liver Injury - metabolism Cholic Acid - metabolism Chromatography, High Pressure Liquid - methods Dioscorea - toxicity Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - toxicity Heterocyclic Compounds, 4 or More Rings - isolation & purification Heterocyclic Compounds, 4 or More Rings - toxicity Least-Squares Analysis Male Mice Mice, Inbred ICR Plants, Medicinal - toxicity Principal Component Analysis Rhizome - toxicity Tandem Mass Spectrometry - methods Taurochenodeoxycholic Acid - metabolism Taurocholic Acid - metabolism Taurodeoxycholic Acid - metabolism
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